Prognostic Significance of Metastasis to the Highest Mediastinal Lymph Node in Nonsmall Cell Lung Cancer

Define relative incomplete resection by highest mediastinal lymph node metastasis for non-small cell lung cancers: Rationale based on prognosis analysis

“…2). Of note, the survival rate in both Dr. Rami-Porta's and Sakao's reports was even worse (0%) [7,15]. Current findings were also consistent with Dr. Robinson's suggestion that N2 disease consists of diverse sub-categories of advanced NSCLC cancers [11].…”

“…Although it was seemingly a ready consensus, RIR has only been examined in a few trials [13,14]; therefore requires additional supporting data. In the study by Dr. Sakao et al, a total of 53 N2 patients were enrolled, 14 of which had positive highest nodes [15]. Even in a multi-center study conducted by the Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pneumology and Thoracic Surgery (GCCB-S), only 23 (11.3%) enrolled cases met the true criteria of "highest nodal involvement" [7].…”

Clinical Predictors of Persistent Mediastinal Nodal Disease After Induction Therapy for Stage IIIA N2 Non-Small Cell Lung Cancer

“…These clinical prognostic criteria may help surgeons in stratifying patients and properly selecting optimal surgical candidates. T he presence of mediastinal nodal metastasis is associated with poor outcome in patients with non-small cell lung cancer (NSCLC) [1]. A number of previous studies have shown improved survival with the addition of preoperative therapies to surgical resection [2].…”

Artemisinin Inhibits Tumor Lymphangiogenesis by Suppression of Vascular Endothelial Growth Factor C

“…The spread of tumor cells from their primary site to regional lymph nodes via the lymphatics is the first step in the dissemination of many tumor types including breast and non-small-cell lung cancer [1] . Experimental and clinicopathological analyses have revealed that tumors can induce lymphangiogenesis, and can promote lymph node and distant organ metastasis [2] .…”