Prognostic Significance of Mild Cognitive Impairment Subtypes for Dementia and Mortality: Data from the NEDICES Cohort

Abstract

Those with aMd-MCI were at greatest risk of progression to dementia, as in other surveys and might be explored with increased attention in MCI research and in dementia preventive trials.

The Mild Cognitive Impairment (MCI) in Searching for its Clinical Identity, Comment of the NEDICES Cohort Data

“…Several surveys with similar MCI definitions to our study, but with a more extensive psychometric evaluation also showed similar results [10,[39][40][41]. The aMd-MCI is the only stable MCI subgroup in our longitudinal clinical investigation [evolution to more cognitive decline or dementia (15.6%), persistent MCI (35.7%), evolution to CN (10.1%), the rest were dead or ineligible subjects].…”

“…This big research is going on, investigating the evolution of AD from an initial population of cognitively normal subjects (n=200), MCI (n=400) and AD patients (n=200) with sophisticated CSF biomarkers (beta-amyloid, tau) and neuroimaging (MRI, PET) [7][8][9][10][11]. The study begins in 2005 with the enrollment of 800 participants from 56 clinical sites of the United States and Canada.…”

“…In the NEDICES-MCI study, the MCI diagnosis was made by an algorithmic retrospective definition according to the International Working Group recommendations [6,10]. The presence of cognitive impairment was based on performances obtained from the MMSE-37 at baseline [30,31].…”

Combining Gait Speed and Recall Memory to Predict Survival in Late Life: Population‐Based Study

“…In a population of older adults free of dementia, mortality was 52% greater in persons with the lowest memory score (0) in the 3‐word recall item of the MMSE vs. persons with the highest score (3) . Amnestic MCI has been found to be associated with a higher risk of mortality . Several hypotheses can be proposed about the association between memory deficits and survival; persons with memory deficits may underreport signs or symptoms, leading to late diagnosis of diseases affecting survival; another hypothesis is that altered memory reflects alteration in brain structure/functioning (i.e., reduced cognitive reserve due to ischemic lesions and/or B‐amyloid deposition) and its control of physiological systems by neurotransmitters and hormones which could affect survival.…”

“…16 Amnestic MCI has been found to be associated with a higher risk of mortality. 17 Several hypotheses can be proposed about the association between memory deficits and survival; persons with memory deficits may underreport signs or symptoms, leading to late diagnosis of diseases affecting survival; another hypothesis is that altered memory reflects alteration in brain structure/ functioning (i.e., reduced cognitive reserve due to ischemic lesions and/or B-amyloid deposition) and its control of physiological systems by neurotransmitters and hormones which could affect survival. Finally, memory can reflect cognitive frailty due to the presence of depression, use of anticholinergic medications, polypharmacy, infections, sleep problems and other conditions associated with higher mortality risk.…”