Prognostic significance of MUC1, MUC2 and MUC5AC expressions in gastric carcinoma

Clinicopathological and Prognostic Significance of MUC-2, MUC-4 and MUC-5AC Expression in Japanese Gastric Carcinomas

“…MUC-5AC expression was negatively associated with the depth of invasion, venous invasion, gastric NNM than gastric cancer in agreement with the data in ovarian carcinogenesis (Feng et al, 2002), indicating that down-regulated MUC-2 might play an important role in gastric carcinogenesis in agreement with another study (Bu et al, 2010). Additionally, MUC-2 expression was negatively correlated with tumor size, depth of invasion, and TNM staging of gastric cancer, in line with the previous reports (Rakha et al, 2005;İlhan et al, 2010), suggesting that reduced MUC-2 expression might be closely linked to the growth, invasion and progression of gastric cancer. The higher MUC-2 expression in intestinalthan diffuse-type carcinomas gives us a fact that it underlies the molecular mechanisms of the differentiation of both carcinomas, which is remarkably different from the findings of İlhan et al (İlhan et al, 2010).…”

The relationship among PDX1, CDX2, and mucin profiles in gastric carcinomas; correlations with clinicopathologic parameters

“…Similar contrast Wndings were also found for MUC2. In some studies, MUC2 expression was signiWcantly higher in diVuse-type gastric carcinomas (Barresi et al 2006;Leteurtre et al 2006;Ãlhan et al 2010), while others have reported no signiWcant diVerence between the intestinal and diVuse type (Lee et al 2001;Akyürek et al 2002). In concordance with this, our results did not show any signiWcant diVerence for the CDX2 expression and mucin proWles.…”

Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model

“…Meanwhile, we detected the intestinal mucin Muc2 only in a few tumor cells (Fig. 4C), albeit reminiscent of MUC2 expression in humans being most prominent in gastric cancer tissues (33). Thus, SPEM and pseudointestinal metaplasia appear in transformed hyperplastic epithelium and tumors irrespective of the mucosal cell type(s) that express Kras G12D in response to Tff1-CreERT2 activation or transgenic expression from the K19 promoter (6).…”