2016
DOI: 10.3892/ol.2016.5420
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Prognostic significance of Notch ligands in patients with non-small cell lung cancer

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Cited by 11 publications
(5 citation statements)
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“…Kirana et al also reported that a strong expression of JAG2 in tumor cells was associated with a good colorectal cancer‐specific survival (Kirana et al, ). Pancewicz‐Wojtkiewicz et al reported no statistically significant associations between survival and JAG2 expression in nonsmall cell lung carcinoma (Pancewicz‐Wojtkiewicz et al, ). In contrast, JAG2 expression is associated with a poor prognosis in patients with hepatocellular carcinoma (Zhang et al, ) and urinary bladder cancer(Li et al, ).…”
Section: Discussionmentioning
confidence: 99%
“…Kirana et al also reported that a strong expression of JAG2 in tumor cells was associated with a good colorectal cancer‐specific survival (Kirana et al, ). Pancewicz‐Wojtkiewicz et al reported no statistically significant associations between survival and JAG2 expression in nonsmall cell lung carcinoma (Pancewicz‐Wojtkiewicz et al, ). In contrast, JAG2 expression is associated with a poor prognosis in patients with hepatocellular carcinoma (Zhang et al, ) and urinary bladder cancer(Li et al, ).…”
Section: Discussionmentioning
confidence: 99%
“…Snai1 expression and loss of E-Cadherin are associated with several cancers and causing increased migration and invasion (31,32), interestingly a recent study in osteosarcoma found that sub-lethal doxorubicin treatments showed signi cant correlation between EMT and Notch signalling in doxorubicin resistant cell lines(33)which supports our ndings within the context acquired drug resistance. In addition, the Notch pathway ligand, Delta like 1 (DLL1), was shown to be associated with disease recurrence in hepatocellular carcinoma (34) and poor prognosis in non-small cell lung cancer (35). A recent study in Neuroblastoma cell lines, showed that DLL1 is highly expressed in MYCN ampli ed cells, and could be inhibited by miRNAs (36).…”
Section: Discussionmentioning
confidence: 99%
“…The levels of other Notch ligands, including JAG1, JAG2, and DLL1, in NSCLC were also observed to be lower than that in normal lung tissue. 131 Furthermore, DLL4 and Notch1 emerged as independent prognostic factors for NSCLC but exhibited varying effects in LUAD and LUSC. 132 The inconsistent results across studies may stem from small sample sizes or variations in sample sources.…”
Section: The Notch Signaling Pathway and Cancermentioning
confidence: 99%