Prognostic significance of osteopontin expression in early-stage non-small-cell lung cancer

Abstract

Osteopontin (OPN) is a multifunctional protein, which has recently been shown to be linked to tumorigenesis, progression and metastasis in different malignancies. Since non-small-cell lung cancer (NSCLC)'s prognosis remains bad, with few predictors of outcome, the purpose of this study was to evaluate if OPN might be involved in NSCLC's biology and therefore represent a prognostic marker and a target for new therapeutic trials. Immunohistochemistry was used to detect OPN expression, evaluated as percentage of neoplastic cells with cytoplasmic immunoreactivity, in a wide cohort of patients with stage I NSCLC (136 cases). The median value of this series (20% of positive cells) was used as the cutoff value to distinguish tumours with low (o20%) from tumours with high (X20%) OPN expression. A statistically significant correlation between high levels of OPN and shorter overall (P ¼ 0.034) and disease-free (P ¼ 0.011) survival in our patients was shown. Our results support the hypothesis that high OPN expression is a significantly unfavourable prognostic factor for the survival of patients with stage I NSCLC. This conclusion has notable importance in terms of the biological characterization of early-stage tumours and therapeutic opportunities.

Prognostic significance of osteopontin expression in non-small-cell lung cancer: A meta-analysis

“…A further 2 studies were excluded [one focused on the association between OPN and bone metastases (17), whereas the other provided limited data on HR and 95% CI (18) and the authors were unavailable for more detailed information]. In addition, after performing an in-depth check of the literature, we found that the same cohort was enrolled in two reports (19,20) and only considered the study by Donati et al (19), which had a larger sample size and included more detailed information. Finally, 6 studies were considered eligible for the meta-analysis, comprising a total of 776 patients (Fig.…”

Prognostic impact of nm23‐H1 and PCNA expression in pathologic stage I non‐small cell lung cancer

“…One of the reasons for this variation is that stage I NSCLC includes populations with a different grade of malignancy [4]. This observation underlines how important it is to identify novel pathological parameters in addition to disease stage and, most of all, new biological markers, in order to add further prognostic information, select high-risk patients for aggressive adjuvant treatments [5].…”

Protein Expression of Osteopontin in Tumor Tissues Is an Independent Prognostic Indicator in Gastric Cancer

“…[11,12,13,14,15,16]. A growing body of clinical evidence supports a role for OPN as a potential prognostic indicator for human cancers including lung, esophagus, prostate, ovarian, hepatocellular and breast cancers [17,18,19,20,21,22,23,24]. Several studies have reported that OPN mRNA, protein expression and plasma level are all closely correlated with invasion and metastasis of GC [26,27,28,29,30].…”

“…Recent clinical evidence suggests that OPN is a valuable prognostic indicator of various human cancers, including lung, esophagus, prostate, ovarian, hepatocellular and breast cancer [17,18,19,20,21,22,23,24]. For example, OPN mRNA overexpression was associated with portal-vein invasion, and had the potential for predicting early recurrence and short patient survival in early-stage hepatocellular cancer [22].…”