Prognostic significance of p27/KIP1 protein (p27) and Ki-67 growth fraction in non-small cell lung cancers (NSCLCs)

Hommura, Fumihiro; Dosaka‐Akita, Hirotoshi; Mishina, Tomobumi; Hiroumi, Hiromitsu; Ogura, Shinji; Shimizu, Michio; Katoh, Hiroyuki; Kawakami, Yoshikazu

doi:10.1016/s0169-5002(00)80618-2

Cited by 62 publications

(74 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[25][26][27] In the current study, the expression of p27 was associated significantly with the expression of cyclin A and cyclin D1, but not with MIB-1. Some studies in vivo that showed no correlation between tumor cell proliferation and p27 have been reported 15,17,20 ; however, the abundance of p27 reflects its function as a p27 Kip1 in Renal Cell Carcinoma/Migita et al…”

Section: Discussionmentioning

confidence: 99%

Low expression of p27^Kip1 is associated with tumor size and poor prognosis in patients with renal cell carcinoma

Migita

Oda

Naito

et al. 2002

Cancer

View full text Add to dashboard Cite

The fast increase in the incidence of childhood type 1 diabetes mellitus (T1DM) that cannot be explained by changes in the genetic susceptibility, led us to look for environmental causes. To test the hypothesis that the initiation of the autoimmune process of childhood T1DM in genetically susceptible subjects begins in the perinatal period by a viral infection, we studied the seasonal variations in the month of birth of several cohorts of patients compared to the general population. Population groups with high or low T1DM incidence were analyzed separately by t‐test and the Cosinor methods. In areas with populations with a high incidence (Israeli Jews, Sicily, Sardinia, Slovenia, Germany) we found that the children (in Sicily also young adults) who subsequently developed T1DM, have a higher incidence of births in the summer months than in other seasons of the year, a mirror image of the seasonality of the clinical onset of disease. This pattern differed significantly from the seasonality of the total live births in the same populations. In populations with a low T1DM incidence, (China, Japan and Cuba) no seasonality of month of birth was found. Similar findings have been reported, from five counties in the U.K. and the Netherlands. It is hypothesized that mothers who become pregnant during the period of yearly viral epidemics transmit to the fetus, either a virus or antiviral antibodies, which determine whether an autoimmune process against the pancreatic β is initiated or whether the fetus is protected against that process. © 2002 Wiley‐Liss, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Low expression of p27^Kip1 is associated with tumor size and poor prognosis in patients with renal cell carcinoma

Migita

Oda

Naito

et al. 2002

Cancer

View full text Add to dashboard Cite

show abstract

“…For the cyclin D1 and Ki-67 staining, slides and results that had been reported previously 12,14 were used for the current study. Tumors were scored as cyclin D1 positive (ϩ) if at least several malignant cells had nuclear staining for cyclin D1 and scored as cyclin D1 negative (Ϫ) if no malignant cells had any nuclear staining.…”

Section: Tumor Specimens and Survival Datamentioning

confidence: 99%

Increased expression of β‐catenin predicts better prognosis in nonsmall cell lung carcinomas

Hommura

Furuuchi

Yamazaki

et al. 2002

Cancer

View full text Add to dashboard Cite

BACKGROUNDβ‐Catenin has been shown to function as a Wnt signaling molecule to stimulate cyclin D1 expression and cell growth in several kinds of tumors.METHODSThe authors immunohistochemically examined specimens of 217 surgically resected primary nonsmall cell lung carcinomas (NSCLCs) for β‐catenin expression and classified them semiquantitatively into three categories, including those with high, moderate, and low scores of expression.RESULTSHigh, moderate, and low scores of expression were found in 37 (17.1%), 145 (66.8%), and 35 (16.1%) tumors, respectively. β‐Catenin expression was not correlated with cyclin D1 expression, but was positively correlated with the Ki‐67 cell growth fraction (P = 0.04). The direct sequencing analysis for the β‐catenin gene mutation of 13 specimens of 217 tumors for the current study revealed no mutations. The relation between survival and β‐catenin expression was evaluated in 148 potentially curatively resected tumors with pathologic Stages I–IIIA. A trend toward better survival was found in patients with tumors having higher scores. In multivariate analysis, high β‐catenin expression was a significant and independent favorable prognostic factor (hazards ratio, 0.31; P = 0.007) as was pathologic stage. Analyzed by cell type, in nonsquamous cell carcinomas, patients with tumors having high scores survived a significantly longer time than those with tumors having moderate or low scores (5‐year survival rates, 84%, 55%, and 32%, respectively; P = 0.02), and high β‐catenin expression tended to be a favorable prognostic factor (hazards ratio, 0.32; P = 0.052).CONCLUSIONSThese results indicate that, in NSCLCs, increased expression of β‐catenin can predict favorable prognosis of patients with resected tumors, suggesting that accumulation of β‐catenin has no or little oncogenic effect via activation of the Wnt pathway, unlike in colon carcinomas or hepatomas. Cancer 2002;94:752–8. © 2002 American Cancer Society.DOI 10.1002/cncr.10213

show abstract

“…For the Ki-67 staining, the results that were previously reported (Hommura et al, 2000) were used for the present study.…”

Section: Immunohistochemistry For Galnac-t3 Expressionmentioning

confidence: 99%

N-acetylgalactosaminyl transferase-3 is a potential new marker for non-small cell lung cancers

et al. 2002

Self Cite

View full text Add to dashboard Cite

N-acetylgalactosaminyl transferase-3 (GalNAc-T3) is an enzyme involved in the initial glycosylation of mucin-type O-linked proteins. In the present study, we used immunohistochemistry to examine GalNAc-T3 expression in 215 surgically resected non-small cell lung cancers. We analysed the biological and clinical importance of GalNAc-T3 expression, especially with regard to its potential as a prognostic factor. We found that normal bronchial epithelial cells, bronchial gland cells, and alveolar pneumocytes showed cytoplasmic immunostaining for GalNAc-T3. Low expression of GalNAc-T3, observed in 93 of 215 tumours (43.4%), was found more frequently in tumours from smokers than those from nonsmokers (P=0.001), in squamous cell carcinomas than nonsquamous cell carcinomas (P50.0001), and in moderately and poorly differentiated tumours than well differentiated tumours (P=0.0002). Multivariate logistic regression analysis showed that an association of low GalNAc-T3 expression with squamous cell carcinomas was the only one significant relationship of GalNAc-T3 expression with various factors (P50.0001). Moreover, tumours losing GalNAc-T3 expression had a significantly higher Ki-67 labelling index than tumours retaining GalNAc-T3 expression (P=0.0003). Patients with low GalNAc-T3 expression survived a significantly shorter time than patients with high GalNAc-T3 expression in 103 pStage I non-small cell lung cancers (5-year survival rates, 58% and 78%, respectively; P=0.02 by log-rank test) as well as in 61 pStage I nonsquamous cell carcinomas (5-year survival rates, 63% and 85%, respectively; P=0.03). Low GalNAc-T3 expression was an unfavourable prognostic factor in pStage I non-small cell lung cancers (hazards ratio, 2.04; P=0.03), and in pStage I nonsquamous cell carcinomas (hazards ratio, 2.70; P=0.03). These results suggest that GalNAc-T3 is a new marker of non-small cell lung cancers with specificity for histology and prognosis.

show abstract

Prognostic significance of p27/KIP1 protein (p27) and Ki-67 growth fraction in non-small cell lung cancers (NSCLCs)

Cited by 62 publications

References 0 publications

Low expression of p27^Kip1 is associated with tumor size and poor prognosis in patients with renal cell carcinoma

Low expression of p27^Kip1 is associated with tumor size and poor prognosis in patients with renal cell carcinoma

Increased expression of β‐catenin predicts better prognosis in nonsmall cell lung carcinomas

N-acetylgalactosaminyl transferase-3 is a potential new marker for non-small cell lung cancers

Contact Info

Product

Resources

About

Prognostic significance of p27/KIP1 protein (p27) and Ki-67 growth fraction in non-small cell lung cancers (NSCLCs)

Cited by 62 publications

References 0 publications

Low expression of p27Kip1 is associated with tumor size and poor prognosis in patients with renal cell carcinoma

Low expression of p27Kip1 is associated with tumor size and poor prognosis in patients with renal cell carcinoma

Increased expression of β‐catenin predicts better prognosis in nonsmall cell lung carcinomas

N-acetylgalactosaminyl transferase-3 is a potential new marker for non-small cell lung cancers

Contact Info

Product

Resources

About

Low expression of p27^Kip1 is associated with tumor size and poor prognosis in patients with renal cell carcinoma

Low expression of p27^Kip1 is associated with tumor size and poor prognosis in patients with renal cell carcinoma