Prognostic significance of p53 and FHIT in advanced oropharyngeal carcinoma

Otero-Garcia, Jose E.; Youssef, Emad; Enamorado, Ileana I.; Du, Wei; Yoo, George H.; Merati, Kambiz; Kewson, Danny; Lonardo, Fulvio; Jacobs, John R.; Kim, Harold

doi:10.1016/j.amjoto.2004.01.001

Cited by 13 publications

(10 citation statements)

References 14 publications

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“…In the case of SCC, however, some researchers have found that p53 expression is not associated with either a favorable or unfavorable outcome in HNSCC (16), pharyngeal SCC (17), or oral SCC and OPSCC (18)(19)(20). Still other authors (21-25) have claimed to have observed a significant correlation between low p53 expression and poor survival in HNSCC, whereas yet others (26,27) observed a positive correlation in OPSCC patients treated primarily with surgery. Specifically, these investigators found an increased survival in patients with p53 overexpression (27) and a higher risk of recurrence in patients with lower p53 expression.…”

Section: Prognostic Role Of P53 Expressionmentioning

confidence: 90%

“…Still other authors (21-25) have claimed to have observed a significant correlation between low p53 expression and poor survival in HNSCC, whereas yet others (26,27) observed a positive correlation in OPSCC patients treated primarily with surgery. Specifically, these investigators found an increased survival in patients with p53 overexpression (27) and a higher risk of recurrence in patients with lower p53 expression.…”

Section: Prognostic Role Of P53 Expressionmentioning

confidence: 90%

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Oropharyngeal Squamous Cell Carcinoma Treated With Radiotherapy or Radiochemotherapy: Prognostic Role of TP53 and HPV Status

Fallai

Perrone

Licitra

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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Section: Prognostic Role Of P53 Expressionmentioning

confidence: 90%

Section: Prognostic Role Of P53 Expressionmentioning

confidence: 90%

Oropharyngeal Squamous Cell Carcinoma Treated With Radiotherapy or Radiochemotherapy: Prognostic Role of TP53 and HPV Status

Fallai

Perrone

Licitra

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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“…In addition, patients whose tumours showed low or no expression of Fhit had significantly shorter disease‐free survival. Interestingly, a more recent study showed that no reduction in Fhit expression by IHC predicted a significantly poorer outcome in patients with advanced oropharyngeal cancer (Otero‐Garcia et al . 2004).…”

mentioning

confidence: 99%

Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma

Thomas

Nadiminti

Regalado

2005

Int J Experimental Path

181

165

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SummaryHead and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract and can destroy the structure and function of organs involved in voice, speech, taste, smell and hearing, as well as vital structures necessary for survival. HNSCC has long been a treatment challenge because of the high rate of recurrences and of advanced disease at the time of diagnosis. Molecular identification of tissue biomarkers in diagnostic biopsy specimens may not only identify patients at risk for developing HNSCC but may also select patients that may benefit from more aggressive treatment modalities. Several biomarkers studied to date such as the proteins p53, cyclin D1, p16, Cox-2 enzyme, epidermal growth factor and vascular endothelial growth factor receptors, matrix metalloproteinases and the Fhit marker for genomic instability could be manipulated for the therapeutic benefit of these patients. This review presents the most updated information on molecular biomarkers with the greatest prognostic potential in HNSCC and discusses some factors that contribute to the controversy concerning their prognostic importance.

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“…In fact, the ultra structural changes which occur especially in tumor cells, and in a much lower measure, in the no transformed tissues from the proximity of the tumor, are caused by changes in the structure and expression of some genes involved in cell cycle control, apoptosis and methastasis 8,11,13 .…”

Section: Real-time Pcr Resultsmentioning

confidence: 99%

Comparative study of primary and secondary tumors from patients with laryngeal and oropharyngeal cancer, using transmission electron microscopy

et al. 2008

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In modern laboratories, the study of cancer is performed using a series of cellular and molecular methods based on optical instruments measurements. Optical and electron microscopy are valuable tools for revealing morphological features of cancer cells. Our study was focused on laryngeal and oropharyngeal cancers, which have nowadays an increased incidence, especially for women, due to unhealthy habits like tobacco and alcohol consumption. We used transmission electron microscopy (TEM) for highlighting the ultrastructural features of cancer cells, both in primary and secondary tumors. The primary tumor is considered that which appears for the first time, at a certain organ; the secondary tumor is that which reappears at the same region or neighbouring regions, at a certain interval of time after the primary one has been surgically removed. The differences between the inner architecture of the cells from primary and secondary tumors where correlated with the expression of some genes (oncogenes and tumor suppressor factors), in order to establish the aggressiveness of the tumor, in different disease stages. The main stress in the study is placed upon electron microscopy, in order to achieve a more precise characterization of both these type of cancer cells. These ultrastructural data complete the image of laryngeal and pharyngeal cancer cells, along with molecular data obtained by Real-Time PCR.

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Prognostic significance of p53 and FHIT in advanced oropharyngeal carcinoma

Cited by 13 publications

References 14 publications

Oropharyngeal Squamous Cell Carcinoma Treated With Radiotherapy or Radiochemotherapy: Prognostic Role of TP53 and HPV Status

Oropharyngeal Squamous Cell Carcinoma Treated With Radiotherapy or Radiochemotherapy: Prognostic Role of TP53 and HPV Status

Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma

Comparative study of primary and secondary tumors from patients with laryngeal and oropharyngeal cancer, using transmission electron microscopy

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