Prognostic Significance of Perineural Invasion in Patients with Gastric Cancer Who Underwent Curative Resection

Bılıcı, Ahmet; Şeker, Mesut; Ustaalıoğlu, Bala Başak Öven; Kefeli, Umut; Yıldırım, Emre; Yavuzer, Dilek; Aydin, Fatih Muhammed; Salepçi, Taflan; Öncel, Mustafa; Gümüş, Mahmut

doi:10.1245/s10434-010-1027-y

Cited by 89 publications

(86 citation statements)

References 21 publications

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“…PNI positive found 31.7% in gastric cancer (Tianhang et al, 2008) and Bilici at al. indicated that PNI positive 75.6% in patients who resected curative intent (Bilici et al, 2010). Last two studies demonstrated PNI independent prognostic factor on survival (Tianhang et al, 2008;Bilici et al, 2010).…”

Section: Resultsmentioning

confidence: 89%

“…Prior few studies demonstrated PNI positivity was from 31.7 to 75.6% (Duraker, 2003;Bilici et al, 2010). This situation may be each study had different patients population based of time diagnosis stage, clinicopathological features and demonstrated different technical stained PNI.…”

Section: Ta B L E 1 C a S S O C I A T I O N B E T W E E N P N I A Nmentioning

confidence: 96%

“…Prior some trials, PNI have not been provided any additional information to the classical prognostic factors (Tanaka et al, 1994;Duraker, 2003). But recently two studies, Bilici et al and Tianhang et al demonstrated that incidence of PNI in gastric cancer was high and PNI independent prognostic factor worse effect on survival (Tianhang et al, 2008;Bilici et al, 2010).…”

Section: Perineural Invasion Independent Prognostic Factors In Patienmentioning

confidence: 99%

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Perineural Invasion Independent Prognostic Factors in Patients with Gastric Cancer Undergoing Curative Resection

Selçukbiricik

Tural²,

Büyükünal³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Resultsmentioning

confidence: 89%

Section: Ta B L E 1 C a S S O C I A T I O N B E T W E E N P N I A Nmentioning

confidence: 96%

Section: Perineural Invasion Independent Prognostic Factors In Patienmentioning

confidence: 99%

See 1 more Smart Citation

Perineural Invasion Independent Prognostic Factors in Patients with Gastric Cancer Undergoing Curative Resection

Selçukbiricik

Tural²,

Büyükünal³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Perineural invasion, which is also called neurotropic carcinomatous spread or perineural spread, is the infiltration of neural fascicles or perineurium by tumor cells. Recent studies have proven that the presence of perineural invasion is an independent prognostic factor for survival and may contribute to the understanding of relapse or metastasis (16 Values were expressed as median (minimum-maximum) or n (%). Table 2.…”

Section: Discussionmentioning

confidence: 99%

Relationship between HER-2, COX-2, p53 and clinicopathologic features in gastric adenocarcinoma. Do these biomarkers have any prognostic significance?

Uğraş

Özgün²,

Ocakoğlu³

et al. 2015

Turk J Gastroenterol

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Background/Aims: The aim of this study was to examine the expression of HER-2, p53 and COX-2 in gastric adenocarcinoma and to investigate whether these markers were useful in predicting the clinicopathologic features. Materials and Methods: Primary gastric adenocarcinoma specimens were obtained from 56 patients who underwent total/subtotal gastrectomy with extended lymphadenectomy between December 2011 -December 2012. We investigated the association between the expression of these markers and clinicopathologic factors by immunohistochemistry. Results: COX-2 positive cases were detected in 28 (50%) of the 56 patients and COX-2 expression was significantly correlated with presence of perineural invasion (p=0,032). 37 cases (66.1%) were defined positive for p53. The expression of p53 was significantly correlated with increasing age (p=0,003), but there was no correlation with other clinicopathological variables. Among the 56 primary gastric cancers, 9 (16.1%) cases showed intermediate (2+) positive expression and 7 (12.5%) cases showed (3+) positive expression for HER-2. No significant correlations were determined between HER-2 and the other variables. Conclusion: Although, this study failed to show any relationship between HER-2 and clinicopathological factors, but our results demondtrated that COX-2 expression might serve as a powerful indicator for estimating perineural invasion, which is an independent worse prognostic factor for survival in gastric adenocarcinoma. Additionally, detecting the expression of p53 can assist with the treatment options for elderly patients with gastric adenocarcinoma. A better understanding of HER-2, COX-2 and p53 expression in gastric adenocarcinoma may improve the staging strategies and influence new treatment modalities.

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“…It was first reported in European literature during the mid-1800s by scientists who described head and neck cancer that exhibited a predilection for growth along nerves as they made their way toward the intracranial fossa (1). PNI has since emerged as a prognostic factor in numerous malignancies, including head and neck, pancreatic cancer, prostate and gastrointestinal cancer types (2)(3)(4)(5). PNI has been generally accepted as a poor prognostic factor in head and neck squamous cell carcinoma (HNSCC) (6).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the association between perineural invasion and clinical and histopathological features of cervical cancer

Wei

Yao

Liu

2016

Molecular and Clinical Oncology

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Abstract. Perineural invasion (PNI) has been investigated as a new prognostic factor in a number of carcinomas. However, studies on PNI in cervical cancer are limited, and inconsistent conclusions have been reported by different groups. The aim of the present study was to analyze the relationship between perineural invasion (PNI) and clinical and histopathological features of cervical cancer, and to evaluate the clinical significance of PNI of cervical cancer. Retrospective review identified 206 patients with cervical cancer who underwent radical hysterectomy plus pelvic lymphadenectomy between December 2012 and August 2014. The association between PNI and clinical and histopathological features of cervical cancer and post-operative radiotherapy was evaluated based on univariate and multivariate analyses. PNI of cervical cancer was identified in 33 of 206 (16%) cervical cancer patients. Univariate analysis demonstrated that PNI was associated with clinical stage, tumor grade, tumor size, depth of invasion, lymphovascular space invasion (LVSI), and lymph node metastasis (P<0.05), but not associated with age and histopathological types (P>0.05). Multivariate analysis suggests that LVSI and lymph node metastasis were associated with PNI of cervical cancer (P<0.05). In addition, post-operative radiotherapy was significantly more recommended for patients with PNI than those without PNI (P<0.001). In conclusion, PNI of cervical cancer is associated with LVSI and lymph node metastasis and can be used as an index for the determination of post-operative radiotherapy for cervical cancer patients.

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Prognostic Significance of Perineural Invasion in Patients with Gastric Cancer Who Underwent Curative Resection

Cited by 89 publications

References 21 publications

Perineural Invasion Independent Prognostic Factors in Patients with Gastric Cancer Undergoing Curative Resection

Perineural Invasion Independent Prognostic Factors in Patients with Gastric Cancer Undergoing Curative Resection

Relationship between HER-2, COX-2, p53 and clinicopathologic features in gastric adenocarcinoma. Do these biomarkers have any prognostic significance?

Evaluation of the association between perineural invasion and clinical and histopathological features of cervical cancer

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