Prognostic Significance of Periostin and Mammalian Target of Rapamycin (mTOR) in Locally Advanced Esophageal Squamous Cell Carcinoma

Jiang, Qi; Chen, Jingjing; Zhang, Boyun; Niu, Junyang; He, Yong

doi:10.12659/msm.904992

Cited by 8 publications

(9 citation statements)

References 29 publications

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“…HRs and 95% CIs were used to evaluate the relationship between POSTN expression and patient prognosis. The fixed-effect model was used if Consequently, 10 articles Jia et al, 2016;Jiang et al, 2017;Li et al, 2015;Lv et al, 2013;Riener et al, 2010;Sung et al, 2016;Thuwajit et al, 2017;Utispan et al, 2010;Wang et al, 2014) were scrutinized after literature retrieval and selection (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…Consequently, 10 articles (Hu et al, ; Jia et al, ; Jiang et al, ; Li et al, ; Lv et al, ; Riener et al, ; Sung et al, ; Thuwajit et al, ; Utispan et al, ; Wang et al, ) were scrutinized after literature retrieval and selection (Figure ). The types of cancers included cholangiocarcinoma, hepatocellular carcinoma, osteosarcoma, esophageal carcinoma, colorectal cancer, and ovarian cancer.…”

Section: Resultsmentioning

confidence: 99%

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Prognostic value of periostin in multiple solid cancers: A systematic review with meta‐analysis

Yang

Deng

Pan

et al. 2019

Journal Cellular Physiology

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Previous studies have shown that the expression of periostin (POSTN) is significantly correlated with prognosis in multiple solid cancers. However, the function of POSTN in tumorigenesis and its relationship with clinical outcomes have not been systematically summarized and analyzed. Thus, a meta-analysis was performed to evaluate the prognostic pertinence of POSTN in solid cancer. We conducted a systematic search in the PubMed, EMBASE, Web of Science, and Cochrane library databases, and a total of 10 studies were used to assess the association of POSTN expression and patients' overall survival (OS) and disease-free survival (DFS). The hazard ratio (HR) or odds ratio (OR) and their corresponding 95% confidence intervals (95% CIs) were further calculated to estimate the association between POSTN and relevant clinical parameters of solid cancer patients. The pooled results indicated that POSTN overexpression was associated with poor OS (HR = 2.35, 95% CI = 1.88-2.93, p < .00001) and DFS (HR = 2.70, 95% CI = 2.00-3.65, p < .00001) in a cohort of 993 patients with cancer. Subsequent analyses showed that the positive expression ratio of POSTN was evidently higher in cancer tissues than in normal tissues (OR = 7.44, 95% CI = 3.66-13.95, p < .00001). In addition, subgroup analysis showed that POSTN was related to microvascular invasion (OR = 5.09, 95% CI = 3.07-8.44, p < .00001), tumor differentiation (OR = 2.03, 95% CI = 1.41-2.91, p = .0001), and lymph node metastasis (OR = 3.05, 95% CI = 2.01-4.64, p < .00001). These data showed that POSTN could be a credible prognostic biomarker and a potential therapeutic target in human solid cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Prognostic value of periostin in multiple solid cancers: A systematic review with meta‐analysis

Yang

Deng

Pan

et al. 2019

Journal Cellular Physiology

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“…The clinical and pathological data were retrospectively collected from medical records, with the date of last follow-up being July 2019. These data included age, sex, tumor location, tumor depth, presence of lymph node metastasis, lymphatic and venous invasion, and Tumor-Node-Metastasis (TNM) classification defined by The TNM Classification of Malignant Tumors, 8th edition ( 16 ). This study was retrospective and the tissue samples for the patients were obtained from the Department of Gastrointestinal Tract Surgery and the Department of Diagnostic Pathology, Fukushima Medical University.…”

Section: Methodsmentioning

confidence: 99%

“…TNM, Tumor-Node-Metastasis. Invasion depth (T stage) was determined according to the TNM classification of Malignant Tumors 8th edition ( 16 ).…”

Section: Figurementioning

confidence: 99%

Stromal expression of cancer‑associated fibroblast‑related molecules, versican and lumican, is strongly associated with worse relapse‑free and overall survival times in patients with esophageal squamous cell carcinoma

et al. 2021

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Cancer-associated fibroblasts (CAFs) in the tumor microenvironment play an essential role in the tumor progression of esophageal squamous cell carcinoma (ESCC). The present study aimed to investigate the expression of CAF-related molecules, versican, periostin and lumican, in cancer stroma, to provide prognostic stratification for patients with ESCC after surgery. A total of 106 patients with ESCC who underwent curative esophagectomy without preoperative chemotherapy or radiotherapy were enrolled. The expression of CAF-related stromal proteins, including versican, periostin and lumican, was examined using immunohistochemistry, and the prognostic value was assessed by Kaplan-Meier survival analysis, and univariate and multivariate Cox regression models. The expression of versican, periostin and lumican was found specifically in the stromal component of ESCC. Kaplan-Meier analysis demonstrated that, compared with a low expression level, a high expression level of versican, periostin or lumican in the cancer stroma was significantly associated with worse relapse-free survival (RFS) and overall survival times in patients with ESCC. The prognostic values of stromal versican and lumican remained significant in a stratified analysis of stage I patients. Moreover, univariate and multivariate analysis revealed that high stromal versican or lumican expression was an independent prognostic factor for RFS in the patients. The present study demonstrated that CAF-related molecules, including versican, periostin and lumican, were expressed in the stroma of ESCC, and that stromal expression of versican and lumican in particular may have clinical utility as a prognostic biomarker for poor RFS in postoperative patients with ESCC.

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“…mTOR is activated in a variety of malignant tumors and is an important regulator of cell proliferation and protein translation (14). mTOR might be a potential target strategy for ESCC treatment in the future because it is highly expressed in many human ESCC tumor tissues and is associated with various clinical characteristics (15)(16)(17). The deregulation of the mTOR signaling pathway in many cancers suggests that mTOR inhibitors may have broad therapeutic use in various tumor types (18).…”

Section: Introductionmentioning

confidence: 99%

Ethyl Ferulate Suppresses Esophageal Squamous Cell Carcinoma Tumor Growth Through Inhibiting the mTOR Signaling Pathway

et al. 2022

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Ethyl ferulate is a phenylpropanoid compound isolated from the medicinal herb Ferula. Although ethyl ferulate has anti-inflammatory, antioxidant, and neuroprotective activities with potential use in the nutraceutical and pharmaceutical industry, its anticancer effects and underlying molecular mechanisms against esophageal squamous cell carcinoma (ESCC) have not been investigated. This study investigates the anticancer activity and molecular mechanism of ethyl ferulate in ESCC. MTT, focus formation, soft agar, and cell cycle analysis were used to determine the effect of ethyl ferulate on cell proliferation and cell cycle. Potential candidate proteins were screened and verified via Western blotting, in vitro kinase assay, and in vitro pull-down assay. Mammalian target of rapamycin (mTOR) knockdown cell lines were established by lentiviral infection with shmTOR. The effect of ethyl ferulate on tumor growth was assessed using ESCC patient-derived xenograft models. Ethyl ferulate significantly inhibited cell growth and induced G1 phase cell cycle arrest in ESCC cells. Ethyl ferulate reduced the activity of mTOR in vitro. The inhibition of ESCC cell growth by ethyl ferulate is dependent on mTOR expression. In addition, ethyl ferulate strongly reduced ESCC patient-derived xenograft tumor growth in an in vivo mouse model. Ethyl ferulate is an mTOR inhibitor that can suppress ESCC progression and may be a novel candidate compound for esophageal cancer chemoprevention.

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Prognostic Significance of Periostin and Mammalian Target of Rapamycin (mTOR) in Locally Advanced Esophageal Squamous Cell Carcinoma

Cited by 8 publications

References 29 publications

Prognostic value of periostin in multiple solid cancers: A systematic review with meta‐analysis

Prognostic value of periostin in multiple solid cancers: A systematic review with meta‐analysis

Stromal expression of cancer‑associated fibroblast‑related molecules, versican and lumican, is strongly associated with worse relapse‑free and overall survival times in patients with esophageal squamous cell carcinoma

Ethyl Ferulate Suppresses Esophageal Squamous Cell Carcinoma Tumor Growth Through Inhibiting the mTOR Signaling Pathway

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