Prognostic significance of peritoneal lavage cytology in gastric cancer in Singapore

Chuwa, E.; Khin, Lay Wai; Chan, Weng‐Hoong; Ong, Hock‐Soo; Wong, Wai‐Keong

doi:10.1007/s10120-005-0343-6

Cited by 35 publications

(41 citation statements)

References 26 publications

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“…The present study also revealed that tumors with angiolymphatic invasion had a significantly higher rate of positive PWC. This result supports the theory of peritoneal carcinomatosis, which suggests shedding of cancer cells from both the serosal surface and the lymphatic system [13].…”

Section: Discussionsupporting

confidence: 89%

“…However, when the tumor invaded the serosa (pT3) and adjacent organs (pT4), the percentages of positive PWC were 19% and 73%, respectively. Previous studies also reported that serosal invasion was associated with a higher likelihood of cytological positivity [2,3,13,21,24]. It seems that the invasion of gastric serosa is a prerequisite for transperitoneal metastasis.…”

Section: Discussionmentioning

confidence: 85%

“…Multivariable Cox regression found PWC to be one of the most significant independent predictors of survival. Positive PWC as an independent predictor of survival has been previously reported by many investigators [2,3,6,[8][9][10][11][12][13][14]24] with a mean survival time of 8.6-18.4 months [1,7,8,17,20,24,32]. However, the influence of positive PWC on the survival of patients with gastric cancer has not been consistent.…”

Section: Discussionmentioning

confidence: 94%

“…This is believed to be due to the presence of malignant cells that have already seeded at the time of operation but cannot be detected macroscopically. The usefulness of peritoneal washing cytology (PWC) to identify intraperitoneal free cancer cells, which have the potential for peritoneal dissemination, has been previously reported [6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic significance of peritoneal washing cytology in Thai patients with gastric adenocarcinoma undergoing curative D2 gastrectomy

Euanorasetr

Lertsithichai

2007

Gastric Cancer

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic significance of peritoneal washing cytology in Thai patients with gastric adenocarcinoma undergoing curative D2 gastrectomy

Euanorasetr

Lertsithichai

2007

Gastric Cancer

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“…Lee et al [7] in his study of 1072 patients showed 16% positive cytology. Bhatti etal [8] from Pakistan showed in their retrospective studies of 149 patients, 40% rate of positive peritoneal cytology obtained using laparoscopy. Unlike all this studies the rate positive peritoneal cytology was very high in our study (54%).…”

Section: Discussionmentioning

confidence: 99%

Significance of peritoneal cytology in patients with gastric cancer: a mono institutional experience with 50 patients

et al. 2016

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34histologically proven gastric cancer cases. All patients who were found to have definitive organ metastasis on preoperative imaging were excluded from the study. Study techniqueAll 50 patients underwent exploratory laparotomy via long midline incision. On opening the abdomen, 500 ml sterile normal saline was instilled into the peritoneal cavity which was manually dispersed by shaking the abdomen. The primary tumour was not touched.A washing sample (100 ml) was aspirated from the peritoneal cavity. The specimen was immediately carried to the department of pathology, were sample was centrifuged to make smears which were fixed and stained with PAP (Papanicolau) stain and the slides examined under light microscope.Peritoneal cytology was considered positive when malignant cancer cells were found in the smears. Medical records of each patient were then reviewed in detail and relevant clinical and pathological information were obtained .The patients were then followed for recurrence of disease and mortality either in our follow up clinic or by telephonic conversation. Associations between cytology status (CY) and clinicopathological variables and effect of cytology status on overall survival was evaluated. Study toolsPre structured questionnaire, preoperative staging investigations, pathology reports, cytology result. Data analysisDetailed history and examination and all relevant results were recorded using pre structured data sheet, the final pathology and cytology results were obtained and patient were followed up for an average of 15 months. All these data was entered into a Microsoft soft excel sheet and a master chart was prepared. This was used for making tables and diagrams to represent the data. Statistical correlation was done and tests of significance was calculated. Statistical analysis was done using statistical software R, version 2.13.0.

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Gastric and gastroesophageal junction cancer: Risk factors and prophylactic treatments for prevention of peritoneal recurrence after curative intent surgery

Huang

Rouvelas

Nilsson

2022

Annals of Gastroent Surgery

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Aim Relapse after curative treatment for advanced gastric cancer, and especially peritoneal recurrence, is very common and has a dismal prognosis. The aim of this review is to summarize existing evidence regarding risk factors and prophylactic treatments intending to prevent peritoneal recurrence. Methods A structured search of relevant studies was conducted in MEDLINE, Embase, and the Cochrane Library. Results The main risk factors identified are advanced pathological T‐stage (pT ≥ 3), regional lymph node involvement, diffuse/poorly cohesive type tumor, poorly differentiated cancer, and positive peritoneal wash cytology. Systemic chemotherapy in the perioperative or adjuvant setting improves survival for the patients but despite this peritoneal recurrence remains a common and yet an unsolved clinical problem. Different approaches of intraperitoneal chemotherapy such as hyperthermic intraperitoneal chemotherapy and early postoperative intraperitoneal chemotherapy have shown promising results as prophylactic treatments aiming to prevent peritoneal recurrence. Conclusion Future studies are warranted to find safe and effective treatments to prevent peritoneal recurrence.

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Prognostic significance of peritoneal lavage cytology in gastric cancer in Singapore

Cited by 35 publications

References 26 publications

Prognostic significance of peritoneal washing cytology in Thai patients with gastric adenocarcinoma undergoing curative D2 gastrectomy

Prognostic significance of peritoneal washing cytology in Thai patients with gastric adenocarcinoma undergoing curative D2 gastrectomy

Significance of peritoneal cytology in patients with gastric cancer: a mono institutional experience with 50 patients

Gastric and gastroesophageal junction cancer: Risk factors and prophylactic treatments for prevention of peritoneal recurrence after curative intent surgery

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