Prognostic significance of pleural lavage cytology in patients with lung cancer: A meta-analysis

Li, Y.-N.; Shi, Huan‐Zhong; Liang, Qian; Yang, Haibo; Huang, Guangwu

doi:10.1016/j.lungcan.2007.09.024

Cited by 18 publications

(15 citation statements)

References 39 publications

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“…PLC status in patients undergoing surgical treatment for lung cancer is widely accepted to be a powerful prognosisassociated factor, as reported previously by many investigators [1][2][3][4][5][6][7][8][9], some who showed that it was an independent prognostic indicator by multivariate analyses [2][3][4]8]. In contrast, according to our preliminary report [9], PLC status immediately after thoracotomy was statistically lacking in prognostic value, although it univariately influenced postoperative survival.…”

Section: Commentssupporting

confidence: 62%

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Prognostic value of intraoperative pleural lavage cytology for lung cancer without carcinomatous pleuritis: importance in patients with early stage disease during long-term follow-up☆

Higashiyama

Oda

Okami

et al. 2009

European Journal of Cardio-Thoracic Surgery

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Based on the present analysis of long-term follow-up after operation, PLC may also be an independent prognostic factor. In particular, the PLC status of patients with stage I disease or adenocarcinoma type has an important impact on survival. PLC-positive findings may be a high risk for postoperative pleural recurrence. For PLC-positive patients with stage I disease, careful serial follow-up for more than 5 years is required while paying attention to late pleural recurrence.

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Section: Commentssupporting

confidence: 62%

“…Despite many recent reports regarding intraoperative pleural lavage cytology (PLC) for lung cancer [1][2][3][4][5][6][7][8], the clinical significance has been undetermined in several points. First, it is considered that PLC may be a prognostic factor, but does this apply to all surgical cases of all stage diseases?…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of intraoperative pleural lavage cytology for lung cancer without carcinomatous pleuritis: importance in patients with early stage disease during long-term follow-up☆

Higashiyama

Oda

Okami

et al. 2009

European Journal of Cardio-Thoracic Surgery

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“…With regard to other prognostic factors in early-stage NSCLC patients, several authors have reported the significance of positive intra-operative pleural lavage cytology [13][14][15]. Nakagawa et al reported that positive pleural lavage cytology in p-Stage I NSCLC patients was an independent prognostic factor, whereas no prognostic significance of this parameter was seen for p-Stage IV [13].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological study of p-T1aN0M0 non-small-cell lung cancer, as defined in the seventh edition of the TNM classification of malignant tumors

Igai

Matsuura

Tarumi

et al. 2011

European Journal of Cardio-Thoracic Surgery

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“…Pleural lavage cytology (PLC) is a technique which may increase the accuracy of current prediction models for cancer recurrence in early stage disease 6. Since its first use in 1958,7 several studies have clearly demonstrated a link between the presence of malignant cells in PLC and subsequent early stage pleural dissemination and poor prognosis 8–12.…”

Section: Introductionmentioning

confidence: 99%

Positive pre-resection pleural lavage cytology is associated with increased risk of lung cancer recurrence in patients undergoing surgical resection: a meta-analysis of 4450 patients

Saso

Rao

Ashrafian

et al. 2012

Thorax

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IntroductionThe value of pleural lavage cytology (PLC) in assessing the prognosis of early stage lung cancer is still controversial. No systematic review has investigated the relationship between PLC and lung cancer recurrence. Our primary goal was to investigate the association between positive pre-resection PLC and pleural, distant and overall tumour recurrence in patients undergoing surgical resection. Methods Medline, EMBASE and Google Scholar databases were searched up to 2011. All studies reporting relevant outcomes in both patient groups were included. Data were extracted for the following outcomes of interest: overall, local and distant recurrence; and freedom from death (survivaldoverall and patients with stage I disease only). Random effects meta-analysis was used to aggregate the data. Sensitivity and heterogeneity analysis were performed. Results A meta-analysis of eight studies at maximum follow-up demonstrated a significant association between positive pre-resection PLC and increased risk of post-resection overall recurrence (OR 4.82, 95% CI 2.45 to 9.51), pleural recurrence (OR 9.89, 95% CI 5.95 to 16.44) and distant cancer recurrence (OR 3.18, 95% CI

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Prognostic significance of pleural lavage cytology in patients with lung cancer: A meta-analysis

Cited by 18 publications

References 39 publications

Prognostic value of intraoperative pleural lavage cytology for lung cancer without carcinomatous pleuritis: importance in patients with early stage disease during long-term follow-up☆

Prognostic value of intraoperative pleural lavage cytology for lung cancer without carcinomatous pleuritis: importance in patients with early stage disease during long-term follow-up☆

Clinicopathological study of p-T1aN0M0 non-small-cell lung cancer, as defined in the seventh edition of the TNM classification of malignant tumors

Positive pre-resection pleural lavage cytology is associated with increased risk of lung cancer recurrence in patients undergoing surgical resection: a meta-analysis of 4450 patients

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