Prognostic significance of preoperative consolidation to maximum tumour diameter ratio and SUVmax in pathological stage I lung adenocarcinoma

Kabalak, Pınar Akın; Yılmaz, Ülkü; Ertürk, Hakan; Özmen, Özlem; Demiröz, Şevki Mustafa; Demırağ, Funda; Kızılgöz, Derya; Kavurgacı, Suna; Cengiz, Tuba Inal

doi:10.1111/crj.13102

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…All included studies were retrospective in our study. Most of the studies included were conducted in China and Japan; only two studies originated from Korea ( n = 2) [ 13 , 21 ] and one from Turkey ( n = 1) [ 30 ]. All included studies had an NOS score of at least 7 (with a mean value of 7.45), which meant they were all high-quality studies (Supplementary file Table S 2 ).…”

Section: Resultsmentioning

confidence: 99%

Prognostic value of consolidation-to-tumor ratio on computed tomography in NSCLC: a meta-analysis

et al. 2023

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Background Although several studies have confirmed the prognostic value of the consolidation to tumor ratio (CTR) in non-small cell lung cancer (NSCLC), there still remains controversial about it. Methods We systematically searched the PubMed, Embase, and Web of Science databases from inception to April, 2022 for eligible studies that reported the correlation between CTR and prognosis in NSCLC. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were extracted and pooled to assess the overall effects. Heterogeneity was estimated by I2 statistics. Subgroup analysis based on the cut-off value of CTR, country, source of HR and histology type was conducted to detect the sources of heterogeneity. Statistical analyses were performed using STATA version 12.0. Results A total of 29 studies published between 2001 and 2022 with 10,347 patients were enrolled. The pooled results demonstrated that elevated CTR was associated with poorer overall survival (HR = 1.88, 95% CI 1.42–2.50, P < 0.01) and disease-free survival (DFS)/recurrence-free survival (RFS)/progression-free survival (PFS) (HR = 1.42, 95% CI 1.27–1.59, P < 0.01) in NSCLC. According to subgroup analysis by the cut-off value of CTR and histology type, both lung adenocarcinoma and NSCLC patients who had a higher CTR showed worse survival. Subgroup analysis stratified by country revealed that CTR was a prognostic factor for OS and DFS/RFS/PFS in Chinese, Japanese, and Turkish patients. Conclusions In NSCLC patients with high CTR, the prognosis was worse than that with low CTR, indicating that CTR may be a prognostic factor.

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Section: Resultsmentioning

confidence: 99%

Prognostic value of consolidation-to-tumor ratio on computed tomography in NSCLC: a meta-analysis

et al. 2023

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“…Studies showed that the size of lung adenocarcinoma was relevant to SUVmax. [14][15][16] However, there is no clear conclusion about the relationship between T staging and SUVmax. Therefore, the study of the relationship between…”

Section: Introductionmentioning

confidence: 99%

Relationships between SUVmax of lung adenocarcinoma and different T stages, histological grades and pathological subtypes: a retrospective cohort study in China

et al. 2022

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ObjectivesCancer cell has aberrant metabolism. The purpose of this study aimed to investigate relationships between maximum standard uptake value (SUVmax）of 18fluoro-2-deoxy-d-glucose and T stages, histological grades and pathological subtypes of lung adenocarcinoma.DesignRetrospective cohort study, employing the Kruskal-Wallis, Bonferroni-Dunn and Mann-Whitney tests to compare SUVmax of different T stages, histological grades and pathological subtypes of lung adenocarcinoma.SettingThe outpatients who had aberrant positron emission tomography/CT (PET/CT) images in chest were enrolled this study from August 2016 to November 2018 in Shanghai, China.ParticipantInitial 11 270 patients with suspected lung cancer who underwent PET/CT examinations were surveyed. A total of 1454 patients who were diagnosed as lung adenocarcinoma by pathologist were included in this project.Primary outcome measuresSUVmax value at different tumour-node-metastasis stages of lung adenocarcinoma before surgery.ResultsThe mean SUVmax of patients with lung adenocarcinoma was significantly elevated with the increase in T stages. There were significant evident differences in SUVmax among T1a–T1c (p<0.05). However, after the staging of patients was more than T1 stage, SUVmax of T2a, T2b, T2 visceral pleural invasion, T3 and T4 had not dramatic changes. SUVmax value of lung adenocarcinoma in the same T stage group was the highest in patients with the high grade of malignancy and solid-predominant invasive adenocarcinoma.ConclusionsSUVmax value was significantly associated with T stages, grades of malignancy and pathological subtypes of lung adenocarcinoma.

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Narrative review of optimal prognostic radiological tools using computed tomography for T1N0-staged non-small cell lung cancer

Nakada¹,

Kuroda²

2021

J Thorac Dis

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Various radiological tools can predict the prognosis of non-small cell lung cancer (NSCLC). In this study, we evaluated the prognostic effect of different radiological tools such as whole tumor size (WTS), consolidation size (CS), consolidation tumor ratio (CTR), tumor disappearance ratio (TDR), mediastinal diameter (MD), and ground glass opacity (GGO) using high-resolution computed tomography (HRCT).We reviewed recent retrospective studies on the predictive effect of these radiological tools on disease-free survival (DFS) and overall survival (OS) in patients with T1N0-staged NSCLC. We searched PubMed and the British Library databases for the English literature published from January 2010 to December 2020 and generated a total of 32 publications (NSCLC, n=16; adenocarcinoma, n=16). The TNM classification version 7 was used in 18 studies, and version 8 in 14 studies. The evaluated radiological parameters were WTS, CS including T category, CTR, TDR, MD, presence of GGO, GGO ratio, and pure GGO. This review suggested that CS, MD, and the presence of GGO are optimal prognostic radiological tools for cT1N0-Staged NSCLC. CTR or TDR for part solid nodules (PSNs) is not a well-accepted prognostic factor. Further investigations are required to differentiate between benign scars and malignant components on HRCT and evaluate the prognosis of PSNs (1< CS ≤2 cm) with large WTS in the future.

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Prognostic significance of preoperative consolidation to maximum tumour diameter ratio and SUVmax in pathological stage I lung adenocarcinoma

Cited by 3 publications

References 15 publications

Prognostic value of consolidation-to-tumor ratio on computed tomography in NSCLC: a meta-analysis

Prognostic value of consolidation-to-tumor ratio on computed tomography in NSCLC: a meta-analysis

Relationships between SUVmax of lung adenocarcinoma and different T stages, histological grades and pathological subtypes: a retrospective cohort study in China

Narrative review of optimal prognostic radiological tools using computed tomography for T1N0-staged non-small cell lung cancer

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