Prognostic significance of preoperative mean platelet volume in resected non-small-cell lung cancer

Abstract

Abstract. An increased mean platelet volume (MPV) is an early marker of platelet activation. MPV was also shown to be associated with the pathophysiological characteristics of various types of cancer. A previous study demonstrated that MPV was significantly associated with the overall survival (OS) of patients with advanced non-small-cell lung cancer (NSCLC). However, there has been no analysis of the prognostic effect of MPV on patients with resected NSCLC. The aim of this study was to evaluate the contribution of MPV to the survival of patients with completely resected NSCLC. We retrospectively analyzed 308 consecutive patients with NSCLC who underwent curative resection at Kitano Hospital. The associations between MPV and clinicopathological factors were assessed. We also evaluated the effect of MPV on survival, using the two-tailed log-rank test and the Cox proportional hazards model. A MPV value of 8.50 fl was considered to be the optimal cut-off value for prognosis. A low MPV was not associated with any other clinicopathological factors. The two-tailed log-rank test demonstrated that patients with a low MPV experienced a shorter disease-free survival (DFS) and overall survival (OS) (P=0.011 and 0.001, respectively), compared to those with a high MPV. The multivariate analysis demonstrated that a low MPV was an independent unfavorable prognostic factor for DFS and OS [hazard ratio (HR)=1.713; 95% confidence interval (CI): 1.070-2.742, P=0.025; and HR=2.835; 95% CI: 1.304-6.163, P=0.009, respectively)]. Therefore, we demonstrated that a low MPV predicted an unfavorable prognosis in patients with NSCLC following curative resection.

Lack of Variation in Inflammatory Hematological Parameters between Benign Nodular Goiter and Papillary Thyroid Cancer

“…There are many studies demonstrated that increased MPV was significantly related with colon cancer (Li et al, 2014), lung cancer (Kumagai et al, 2015), gastric cancer (Kılınçalp et al, 2014), endometrial carcinoma (Karateke et al, 2015) and in head and neck neoplasms (Eryilmaz et al, 2015). In the literature, increased N/L ratio was significantly related with the lung cancer (Kemal et al, 2014), gastric cancer (Kim et al, 2015), colon cancer (Absenger et al, 2013) and papillary thyroid cancer DOI:http://dx.doi.org/10.7314/APJCP.2016.17.4.2321 Inflammatory Hematological Parameters in Benign Nodular Goiter andPapillary Thyroid Cancer (Seretis et al, 2013).…”

Can Platelet and Leukocyte Indicators Give Us an Idea about Distant Metastasis in Nasopharyngeal Cancer?

“…One study reported a considerable decrease in the MPV values in some types of cancer (Oncel et al, 2015). Others reported that a significant decrease in the MPV was associated with bone marrow metastasis and increased cell death in advanced-stage cancer (Aksoy et al, 2008;Kumagai et al, 2015). However, there have not been any studies on the relationship between the MPV and NPC.…”

“…Even though studies analysing the relationship between MPV and the other types of cancer have been done we still have little information about the relationship between NPC and MPV. Many studies have analysed the relationship between the MPV and cancer (Aksoy et al, 2008;Kumagai et al, 2015;Oncel et al, 2015). One study reported a considerable decrease in the MPV values in some types of cancer (Oncel et al, 2015).…”

Value of Mean Platelet Volume for Disease Activity in Patients with Pulmonary Sarcoidosis

“…Son zamanlarda yapılan çalışmalarda MPV ile değişik kanser tipleri arasındaki ilişkiye de dikkat çekilmiştir, tedavinin baş-langıcında düşük MPV değerinin ilerlemiş küçük hücreli dışı akciğer kanserli hastalarda kötü prognoz prediktörü olabileceği raporlanmıştır (24,25). Bizim çalışmamızda her ne kadar MPV median değeri normal sınırlar arasında kalsa da ACE yükselirken MPV değerinin düşüyor olması düşük MPV değerlerinin hastalığın prognoz tahmininde kullanabileceğini düşündürmektedir.…”