Prognostic significance of preoperative neutrophil-to-lymphocyte ratio in surgically resected schwannomas

Abstract

ObjectiveThe goal of schwannoma resection is to control the tumor while preserving neurological function. Schwannomas have a variable postoperative growth pattern, therefore preoperative prediction of a schwannoma’s growth pattern is favorable. This study aimed to examine the relationship between preoperative neutrophil-to-lymphocyte ratio (NLR) and postoperative recurrence and retreatment in patients with schwannoma.MethodsWe retrospectively examined 124 patients who underwent schwannoma resection in our institution. Associations between preoperative NLR, other patient and tumor characteristics, and tumor recurrence and retreatment were analyzed.ResultsMedian follow-up was 2569.5 days. Postoperative recurrence occurred in 37 patients. Recurrence that required retreatment occurred in 22. Treatment-free survival (TFS) was significantly shorter in patients with NLR ≥2.21 (P = 0.0010). Multivariate Cox proportional hazards regression showed that NLR and neurofibromatosis type 2 were independent predictors of retreatment (P = 0.0423 and 0.0043, respectively). TFS was significantly shorter in patients with NLR ≥2.21 in the following subgroups: sporadic schwannoma, primary schwannoma, schwannoma ≥30 mm in size, subtotal resection, vestibular schwannoma, and postoperative recurrence.ConclusionsPreoperative NLR ≥2.21 before surgery was significantly associated with retreatment after schwannoma resection. NLR may be a novel predictor of retreatment and assist surgeons in preoperative surgical decision making.

Prognostic significance of HALP score and combination of peripheral blood multiple indicators in patients with early breast cancer

“…The preoperative NLR index has been reported to reduce the prediction of overall survival (OS) and progression-free survival (PFS) in patients with advanced tumors (5). The NLR >/= 2.2 before surgery has been reported to be significantly associated with retreatment after schwannoma resection (7). The high level of PLR was correlated with poor survival time (10), the results demonstrating a significant correlation between elevated PLR and poor prognosis in UC ( 11).…”

“…An immunosuppressive state can occur owing to chronic inflammation and malnutrition, increasing the risk of infection and death in patients with chronic diseases. In recent years, multiple studies have reported the role of peripheral blood biomarkers such as the preoperative neutrophil-to-lymphocyte ratio (NLR) (5)(6)(7)(8)(9), platelet-to-lymphocyte ratio (PLR) (10)(11)(12), lymphocyte-tomonocyte ratio (LMR) (13)(14)(15), and prognostic nutritional index (PNI) (16)(17)(18)(19)(20) to explore the relationship between the physiological and disease status and predict disease-free survival (DFS) in patients with cancer to some extent. The prognosis of breast cancer is intricately associated with inflammation.…”