Prognostic Significance of Preoperative Prognostic Nutritional Index in Epithelial Ovarian Cancer Patients Treated with Platinum-Based Chemotherapy

Miao, Yi; Li, Shuangdi; Yan, Qin; Li, Bilan; Yan, Feng

doi:10.1159/000452263

Cited by 39 publications

(40 citation statements)

References 26 publications

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“…Petefészekrákban (n = 344), a műtét előtti PNI<45 rövidebb progressziómentes (HR 1,890 [95%-os CI 1,396-2,560], p<0,001) és teljes túléléssel (HR 1,747 [95%-os CI 1,293-2,360], p<0,001) társult [24]. [25].…”

Section: Eredményekunclassified

Az albumin prognosztikai jelentősége az onkológiában

Deme¹,

Telekes

2018

Orvosi Hetilap

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A szérumalbuminszint csökkenése figyelhető meg gyulladásos folyamatokban. A helyileg előrehaladott vagy áttétes rosszindulatú daganatokban a szérumalbuminszint ugyancsak csökken, az alultápláltság fennállásától függetlenül. A csökkent albuminszint befolyásolhatja a terápia eredményeit is (például gyógyszerek farmakokinetikája, mellékha-tások mértéke). Kiterjedt szakirodalmi adat és gyakorlati tapasztalat bizonyítja a táplálásterápiában részesülő pácien-sek jobb prognózisát. A szerzők a fontosabb szakirodalmi adatok alapján összefoglalják azon vizsgálatokat, melyek a kiindulási szérumalbuminszint és a rosszindulatú daganatos betegségek prognózisa közötti szoros összefüggést feltárták. Orv Hetil. 2018; 159(3): 96-106. Kulcsszavak: albumin, rosszindulatú daganatok, prognózis Prognostic importance of albumin in oncologyDiminished serum albumin level can be observed in inflammatory processes. Serum albumin level also reduces -irrespective of the presence of malnutrition -in locally advanced or metastatic malignancies. Low serum albumin level may have an influence also on the results of anticancer therapy (e.g., drug pharmacokinetics, adverse drug reactions). Extensive data of the literature and empirical experience prove the better prognosis of patients involved in nutritional therapy. Based on the most relevent data of the literature, the authors summarize the studies which have revealed the close correlation between the baseline serum albumin level and the prognosis of malignant diseases. Rövidítések ALI = (advanced lung cancer inflammation index) előrehala-dott tüdőrák index; APACHE = (acute physiology and chronic health evaluation) heveny élettani és idült egészség értékelés; BC = (breast cancer) emlőrák; BMI = (body mass index) testtömegindex (kg/m 2 ); CI = konfidenciaintervallum; CRC = (colorectal cancer) vastag-és végbélrák; CRP = C-reaktív protein; CRPC = (castration-resistant prostate cancer) kasztráció-rezisztens prostatarák; CSS = (cancer specific survival) daganatspecifikus túlélés; DFS = (disease-free survival) betegségmentes túlélés; DNS = dezoxiribonukleinsav; DSS = (disease-specific survival) betegségspecifikus túlélés; GPS = (Glasgow Prognostic Score) Glasgow prognosztikai pontrendszer; HCC = (hepatocellular carcinoma) primer májrák; HR = (hazard ratio) kockázati hányados; IL = interleukin; IMA = ischaemiamódosított albumin; IPI = (inflammatory prognostic index) gyulladásos prognosztikai index; KPS = Karnofsky Performance Status; LDH = (lactate dehydrogenase) laktátdehidrogenáz; LMR = (lymphocyte-monocyte ratio) abszolút lymphocyta-monocyta arány; mGPS = (modified Glasgow Prognostic Score) módosí-tott Glasgow prognosztikai pontrendszer; mGPS 0, 1, 2 = a módosított Glasgow prognosztikai pontrendszer értékei 0, 1, 2; MSKCC = Memorial Sloan Kettering Cancer Center; nabpaclitaxel = nanopartikuláris albuminhoz kötött paclitaxel; NLR = (neutrophil-lymphocyte ratio) abszolút neutrophillym phocyta arány; NRS = (nutritional risk screening) tápláltsá-gi kockázatszűrés; NSCLC = (non-small cell lung cancer) nem...

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Section: Eredményekunclassified

Az albumin prognosztikai jelentősége az onkológiában

Deme¹,

Telekes

2018

Orvosi Hetilap

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“…This result suggested that the use of PNI in cases of recurrences would more likely reflect the sensitivity to treatment rather than predict the time to recurrence. Previously, Miao et al reported that PNI was useful for predicting platinum resistance in ovarian cancer and was an independent prognostic factor for OS and progression-free survival 21 neutrophil-to-lymphocyte ratio (NLR) at recurrence increased to the same level as preoperative NLR in case of recurrence of OCCC 7 . NLR, as well as PNI, is known as a marker that reflects systemic inflammatory status.…”

Section: Discussionmentioning

confidence: 99%

The Preoperative Prognostic Nutritional Index for the Prediction of Outcomes in Patients with Early-Stage Ovarian Clear Cell Carcinoma

Yoshikawa

Yoshida

Tamauchi

et al. 2020

Sci Rep

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The prognostic nutritional index (PNI), which reflects preoperative malnutrition, is useful for predicting the incidence of postoperative complications and has been reported in recent years to predict the longterm prognosis of various malignancies. The purpose of this study was to clarify the significance of PNI as a prognostic factor for early-stage clear cell ovarian carcinoma. A total of 82 patients with stage I-II (FIGO 2014) ovarian clear cell carcinoma undergoing primary surgery at our hospital from January 2005 to December 2017 were enrolled. PNI was calculated using the formula: 10 × serum albumin (g/ dL) + 0.005 × peripheral blood lymphocyte count (/mm 3 ). preoperative pni exhibited relatively high area under the curve value (0.709) for 5 year survival, and the optimal cutoff value was 46.5. The overall survival was significantly shorter in the PNI-low group than in the PNI-high group. Multivariate analysis showed that high PNI was a significant independent prognostic factor for favorable prognosis (hazard ratio = 0.102, p = 0.010). There was no significant difference in recurrence-free survival between the two groups (p = 0.220), but the postrecurrence survival was significantly longer in the PNI-high group than in the pni-low group (p = 0.0383). The preoperative PNI was a useful predictor of prognosis, even in early-stage ovarian clear cell carcinoma.Ovarian clear cell carcinoma (OCCC) is one of the common histologic subtypes of epithelial ovarian cancer (EOC), accounting for approximately 20% of all EOC in Asian countries but only for 6% of all EOC in Western countries 1-3 . As with the other histologic types of EOC, OCCC frequently presents with various symptoms, including abdominal pain or swelling. In particular, OCCC had been generally associated with ovarian endometriosis, which is characterized by severe dysmenorrhea and chronic pelvic inflammation 4 . Although the majority of OCCC cases are diagnosed in the early-stage and patients with stage IA OCCC have a favorable prognosis, stage IC OCCC with positive peritoneal cytology can lead to poor prognosis due to its high recurrence rate and resistance to conventional platinum-based chemotherapy 5 . Therefore, identification of the clinical indicators that predict long-term outcomes is needed to improve the management of patients with early-stage OCCC.Malnutrition has been reported to make patients more susceptible to infection, increase the risk of postoperative complications, and promote tumor recurrence through suppression of tumor immunity 6-8 . The prognostic nutritional index (PNI), which is calculated using serum albumin level and lymphocyte count as indicators of nutritional status, has been reported to be correlated with survival and perioperative complications in various types of cancer [8][9][10][11] . Even in gynecologic malignancies, low PNI was recently reported to be associated with poor prognosis in HGSOC and cervical cancer 12,13 . Although several reports have shown a correlation between malnutrition and poor prognosis in advanced...

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“…A total of 11 articles were selected for full review, as shown in Figure 1. Six articles were excluded for various reasons, leading to the final inclusion of five articles for study [10][11][12][13]16]. Table 1 summarizes the characteristics of the five included studies.…”

Section: Selection Processmentioning

confidence: 99%

“…However, evidence of the significance of the PNI in OC is controversial. A retrospective study by Feng et al [10] on 875 OC patients revealed null results between preoperative PNI and overall survival (OS) of OC, in contrast to other studies that showed a significant association [11][12][13]. Interestingly, a systematic review and meta-analysis in 2019 by Wang et al [14] showed significant association of the PNI with the prognosis of patients with gynecological cancer.…”

Section: Introductionmentioning

confidence: 99%

“…First, the reference group for comparison was set as OC patients with a low PNI as proposed by Feng et al [10]. Conversely, other included studies [11][12][13] set the reference comparison group as OC patients with a high PNI. These mixed risk estimates were summarized directly instead of recalculating on the basis of comparable reference groups.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Significance of the Preoperative Prognostic Nutritional Index in Epithelial Ovarian Cancer Patients: A Systematic Review and Meta-analysis of Cohort Studies

Gong¹,

Zhang²,

Sun³

et al. 2020

Preprint

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BackgroundThe main aim of this study was to validate the potential association between the preoperative prognostic nutritional index (PNI) and survival of patients with ovarian cancer (OC).MethodsWe systematically searched multiple databases (PubMed, EMBASE, and Web of Science) for publications up to June 30, 2019, to identify observational studies evaluating the PNI in relation to survival. Two reviewers independently extracted data and assessed the quality of each study using the Newcastle-Ottawa Scale (NOS). Summary hazard ratios (HR) and 95% confidence intervals (CI) were calculated with the aid of a random-effects model. The potential for publication bias was explored using Funnel plots as well as Begg’s and Egger’s tests.ResultsAmong the 15,000 studies selected for selection, 5 retrospective cohort studies (4 from China and one from Japan) comprising 1964 OC patients met the inclusion criteria. All studies were graded as ‘low risk of bias’ according to NOS. A low preoperative PNI was associated with poor overall survival (HR = 1.69, 95% CI = 1.16–2.46; I2 = 83.8%) and progression-free survival (HR = 1.86, 95% CI = 1.39–2.51; I2 = 29.7%) of OC patients. No significant publication bias was detected.ConclusionsCollective data from the present systematic review and meta-analysis suggest that a low preoperative PNI is associated with poor survival in OC. Further prospective studies are required to confirm these findings.

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Prognostic Significance of Preoperative Prognostic Nutritional Index in Epithelial Ovarian Cancer Patients Treated with Platinum-Based Chemotherapy

Cited by 39 publications

References 26 publications

Az albumin prognosztikai jelentősége az onkológiában

Az albumin prognosztikai jelentősége az onkológiában

The Preoperative Prognostic Nutritional Index for the Prediction of Outcomes in Patients with Early-Stage Ovarian Clear Cell Carcinoma

Prognostic Significance of the Preoperative Prognostic Nutritional Index in Epithelial Ovarian Cancer Patients: A Systematic Review and Meta-analysis of Cohort Studies

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