Prognostic Significance of Pretreatment Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Patients with Diffuse Large B-Cell Lymphoma

Abstract

It is generally believed that there is correlation between cancer prognosis and pretreatment PLR and NLR. However, there are limited data about their role in diffuse large B cell lymphoma (DLBCL). This study aims to determine the prognostic value of pretreatment PLR and NLR for patients who have DLBCL. The associations between clinical characteristics and NLR and PLR were evaluated among 182 DLBCL patients from January 2005 to June 2016. The optimal cutoff values for high PLR (⩾150) and NLR (⩾2.32) in prognosis prediction were determined. The effect of NLR and PLR on survival was evaluated through multivariate Cox regression analysis, univariate analysis, and log-rank test. According to the evaluation results, patients with high NLR and PLR had significantly shorter OS (P=0.026 and P=0.035) and PFS (P=0.024 and P=0.022) compared with those who have low PLR and NLR. On multivariate analyses, IPI>2, elevated LDH, and PLR⩾2.32 were prognostic factors for OS and PFS in DLBCL patients. Therefore, we demonstrated that high PLR and NLR predicted adverse prognostic factors in DLBCL patients.

<p>Prognostic significance of FA score based on plasma fibrinogen and serum albumin in patients with epithelial ovarian cancer</p>

“…At present, a number of basic experiments and clinical researches worldwide have been conducted to find exact serological laboratory indicators in the hope of a more reliable and accurate judgment of patients with various malignant tumors. Neutrophil/lymphocyte ratio,28 lymphocyte/monocyte ratio,29 serum albumin30 and plasma fibrinogen31 have been confirmed to have an association with prognosis of special kinds of cancers.…”

The prognostic value of NLR for early death in secondary Hemophagocytic lymphohistiocytosis patients: an analysis of 92 patients

“…In recent years, NLR as an in ammation indicator has been well studied in various in ammation associated pathological conditions [10][11][12][13]. Higher NLR was correlated with more advanced disease stage in autoimmune disease [17,18] and it was proved to be an independent prognosis factor in infections disease [11,19], diffuse large B-cell lymphoma [20,21], and so on. Whilst, a higher NLR predicts increased 30-day mortality in critically ill patients [13,22,23].…”

Low platelet to lymphocyte ratio and high platelet distribution width have an inferior outcome in chronic lymphocytic leukaemia patients

“…The antitumour activity of inflammation and the associated immune activation, induce tumour growth and progression. Inflammation is an independent predictor for response to therapy, event-free survival and overall survival (OS) in diffuse large B-cell lymphoma (DLBCL) patients [10].…”

“…Meanwhile, Kang et al demonstrated that PLR had significant association with a poor prognosis in patients with non-Hodgkin's lymphoma, treated by R-CHOP [16]. Wang et al reported that high PLR was associated with shorter OS and PFS in patients with DLBCL [10], also Seo et al found that PLR showed independent significance in patients with advanced stage marginal zone lymphoma treated with rituximab, vincristine, cyclophosphamide, and prednisone protocol [17]. Retrospective analysis of 283 myeloma patients showed that inverse PLR had predictive value for OS and PFS [18].…”