Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in patients with laryngeal cancer: a systematic review and meta-analysis

Yang, Fangyu; Huang, Qiangru; Guan, Zhongying; Diao, Qizhi

doi:10.1007/s00405-020-06337-5

Cited by 9 publications

(21 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, Fangyu Yang et al. also conducted a meta-analysis of the relationship between NLR and laryngeal cancer ( 52 ), but we included more studies (20vs12 studies in Fangyu Yang’s) and more patients (5716vs3746 patients in Fangyu Yang’s). More studies and patients make our research more accurate and scientific.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in laryngeal cancer: What should we expect from a meta-analysis?

Tian

Sun

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

BackgroundAlthough many studies have shown the predictive value of the high neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) for various cancers, there are conflicting reports regarding their role in laryngeal cancer. This study aimed to evaluate the relationship between high NLR/PLR and laryngeal cancer prognosis with the help of meta-analysis.MethodsPubMed, Embase and other databases were used to search relevant studies. The pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated using either the random-effect-model or fixed-effect model. Sensitivity analyses and subgroups were used to explore potential sources of heterogeneity. Publication bias was also adopted.Result5716 patients from 20 studies were involved in this meta-analysis. Pooled observed survival (OS) (HR=1.70, 95%CI, 1.41-2.04, p<0.001), progression-free survival (PFS) (HR=1.81, 95%CI, 1.47-2.23, p<0.001), and disease-free survival (DFS) (HR=1.86, 95%CI, 1.45-2.38, p<0.001) showed the prediction of high NLR for poor prognosis. It also suggested that high PLR predicted poor OS (HR=1.89, 95%CI, 1.21-2.94, p<0.001).ConclusionThis study indicated that high NLR was associated with poor OS, PFS, and DFS in laryngeal cancer patients, and high PLR was related to poor OS. Both could be potential predictors of prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in laryngeal cancer: What should we expect from a meta-analysis?

Tian

Sun

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…The neutrophils, lymphocytes, platelets, monocytes and C-reactive protein are all common inflammatory biomarkers and a great number of studies have revealed the prognostic role of NLR, PLR, LMR and GPS in tumors. Several met-analyses demonstrated that elevated pretreatment NLR was a prognostic risk factor in colorectal cancer (HR = 1.57, 95%CI: 1.39-1.78, P < 0.001)[ 36 ], gastric cancer (HR = 1.78, 95%CI: 1.59-1.99, P < 0.001)[ 37 ], laryngeal cancer (HR = 1.76, 95%CI: 1.53-2.03, P < 0.001)[ 38 ] and non-small cell lung cancer patients (HR = 2.86, 95%CI: 2.11-3.87, P < 0.001)[ 39 ]. Furthermore, the prognostic value of GPS has been verified in ovarian cancer (HR = 1.62, 95%CI: 1.38-1.91, P < 0.001), esophageal squamous cell cancer (HR = 1.66, 95%CI: 1.14-2.41, P = 0.008), colorectal cancer (HR = 2.20, 95%CI: 1.88-2.57, P < 0.001) and lung cancer patients (HR = 2.058, 95%CI: 1.51-2.80, P < 0.05) by several meta-analyses[ 14 , 40 - 42 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of neutrophil/lymphocyte, platelet/lymphocyte, lymphocyte/monocyte ratios and Glasgow prognostic score in osteosarcoma: A meta-analysis

Peng¹,

Li²,

Li³

2022

WJCC

View full text Add to dashboard Cite

BACKGROUND Some studies investigated the prognostic role of several blood biomarkers, including the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR) and Glasgow prognostic score (GPS), in osteosarcoma, but their results were inconsistent with each other. AIM To identify the prognostic value of NLR, PLR, LMR and GPS in osteosarcoma patients through reviewing relevant studies. METHODS The PubMed, EMBASE, Web of Science and CNKI databases were searched up to October 2, 2021. The primary and second outcomes were overall survival (OS) and disease-free survival (DFS), respectively. The hazard ratios (HRs) with 95% confidence intervals (CIs) were combined to assess the association between these indicators and prognosis of osteosarcoma patients. RESULTS A total of 13 studies involving 2087 patients were eventually included. The pooled results demonstrated that higher NLR and GPS were significantly associated with poorer OS (HR = 1.88, 95%CI: 1.38-2.55, P < 0.001; HR = 2.19, 95%CI: 1.64-2.94, P < 0.001) and DFS (HR = 1.67, 95%CI: 1.37-2.04, P < 0.001; HR = 2.50, 95%CI: 1.39-4.48, P < 0.001). However, no significant relationship of PLR and LMR and OS ( P = 0.085; P = 0.338) and DFS ( P = 0.396; P = 0.124) was observed. CONCLUSION Higher NLR and GPS were related with worse prognosis and might serve as novel prognostic indicators for osteosarcoma patients.

show abstract

“…Malnutrition is a common postoperative complication in patients with laryngeal cancer due to dysphagia and patients with preoperative malnutrition have poorer prognosis. Recently, various inflammation-related and nutritional indicators, like NLR, [14][15][16][17] PLR, 16,18 and PNI, 19,20 have been applied to evaluate the prognosis of laryngeal cancer. To the best of our knowledge, the present study was the first research to assess the value of the CONUT score for predicting the prognosis of laryngeal cancer.…”

Section: Discussionmentioning

confidence: 99%

Controlling Nutritional Status (CONUT) score is a prognostic marker for laryngeal cancer patients with curative resection

Lin

Chen

et al. 2022

Head & Neck

View full text Add to dashboard Cite

Background To investigate the prognostic value of pre‐treatment Controlling Nutritional Status (CONUT) score in laryngeal cancer. Methods Preoperative CONUT score was retrospectively calculated in 154 laryngeal cancer patients who underwent curative resection in our hospital from 2013 to 2016. The associations of CONUT with clinicopathological factors and survival were evaluated. The efficacy of CONUT score to predict prognosis was evaluated. Results The CONUT score was associated with body mass index (p = 0.033), neutrophil (p = 0.011), tumor size (p = 0.017), pTNM stage (p = 0.001), adjuvant radiotherapy (p < 0.001), negative pathologic factors (p < 0.001), and larynx preservation (p < 0.001). Patients with a higher CONUT score had worse overall survival (hazard ratio: 1.94, 95% confidence interval [CI]: 1.13–3.72, p = 0.039) and disease‐free survival (hazard ratio: 2.16, 95% CI: 1.19–3.90, p = 0.011). The area under the curve of CONUT score (0.728) was higher than Preoperative Nutritional Index (0.72), platelet‐to‐lymphocyte ratio (0.675), and neutrophil‐to‐lymphocyte ratio (0.687). Conclusion The CONUT score can be useful for predicting survival in laryngeal cancer patients after curative resection.

show abstract

Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in patients with laryngeal cancer: a systematic review and meta-analysis

Cited by 9 publications

References 38 publications

Prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in laryngeal cancer: What should we expect from a meta-analysis?

Prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in laryngeal cancer: What should we expect from a meta-analysis?

Prognostic value of neutrophil/lymphocyte, platelet/lymphocyte, lymphocyte/monocyte ratios and Glasgow prognostic score in osteosarcoma: A meta-analysis

Controlling Nutritional Status (CONUT) score is a prognostic marker for laryngeal cancer patients with curative resection

Contact Info

Product

Resources

About