“…Since the uPA gene promoter contains a binding site for Ets, and Ets1 is a major transcription factor regulating uPA gene expression, enhanced expression of uPA gene in transformed cells is largely attributed to overexpression of Ets-1 (Watabe et al, 1998;D'Orazio et al, 1997;Stacey et al, 1995). uPA is a serine protease and contributes to tumor invasion by degrading extracellular matrix components, and thus its expression is widely correlated with tumor metastasis (Testa and Quigley, 1990;Bindal et al, 1994). PAI-1 is an inhibitor of uPA, but paradoxically expression of PAI-1 also correlates with tumor metastasis (Sappino et al, 1991;GrondahoHansen et al, 1993;Foekens et al, 1994).…”