Prognostic Significance of Receptor-Binding Cancer Antigen Expressed on SiSo Cells (RCAS1) Expression in Relation to Cadherin Expression in Patients with Colorectal Carcinoma

Tsujitani, Shunichi; Saito, Hiroaki; Honboh, Takuya; Ataka, Masayuki; Tanida, Takashi; Makino, Masato; Ikeguchi, Masahide

doi:10.1007/s10350-007-0223-8

Cited by 9 publications

(8 citation statements)

References 36 publications

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“…RCAS1 expression has been significantly correlated with lymph node metastasis, venous invasion, Dukes stage, serum levels of carcinoembryonic antigen, and poor prognosis in patients with colorectal adenocarcinoma [13]. Interestingly, RCAS1 expression has been found more frequently in tumors with reduced or abnormal E-cadherin expression, thereby supporting evidence that both proteins may be critical for the mechanism of metastasis and recurrence in human colorectal cancer [13].…”

Section: Discussionmentioning

confidence: 95%

“…In this context, elevated RCAS1 expression, as assessed by immunohistochemistry, has been reported in the tumor malignant stage of several organs, including the uterus [6], skin [7], liver [8], gall bladder [9], stomach [10], lung [11], colon [12,13], breast [14], esophagus [15], and pancreas [16]. RCAS1 expression has also been found to be correlated with important clinicopathological parameters and with patient survival in several of these malignant tumors; as such, it has been considered to be an indicator of poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

“…RCAS1 expression has also been found to be correlated with important clinicopathological parameters and with patient survival in several of these malignant tumors; as such, it has been considered to be an indicator of poor prognosis. In fact, histological RCAS1 expression has been related with the clinical stages of several tumor malignancies, such as uterine squamous cell carcinoma [6], nonsmall cell carcinoma of the lung [11], squamous cell carcinoma of the skin [7], and colorectal carcinoma [13]. Recent studies have also revealed that serum RCAS1 concentrations as determined by enzyme-linked immunosorbent assay (ELISA) could be a new marker in the screening procedures for several malignancies, including ovarian [17], lung [18], and pancreatic cancer [5].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Significance of Tumor-associated Antigen RCAS1 Expression in Human Pancreatic Ductal Adenocarcinoma

et al. 2007

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Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that induces cell cycle arrest and/or apoptosis in RCAS1 receptor-expressing immune cells. The aim of the present study was to evaluate the clinical significance of RCAS1 expression in human pancreatic adenocarcinoma. Immunohistochemical analysis of RCAS1 expression was performed on paraffin-embedded tissue sections obtained from 76 pancreatic adenocarcinoma patients. RCAS1 positivity and overexpression and intensity of the staining were correlated with clinicopathological parameters, proliferative capacity and patient survival. Of the 76 adenocarcinoma patients, 65 (86%) tested positive for RCAS1; of these 65 RCAS1-positive cases, 36 (55%) showed RCAS1 overexpression. RCAS1 positivity was statistically significantly correlated with the histopathological grade of the tumor (P = 0.026), and it showed a trend to be correlated with tumor size (P = 0.071). RCAS1 intensity and overexpression of staining showed a trend to be correlated with the histopathological grade of the tumor (P = 0.061 and P = 0.089, respectively), whereas RCAS1 positivity and the overexpression and intensity of staining were not statistically significantly correlated with the proliferative capacity of the tumor or any other clinicopathological parameter examined nor with patients' survival. Our data provide evidence for the implication of RCAS1 in pancreatic neoplasia. However, the prediction of survival using RCAS1 expression as a marker seems uncertain for this type of cancer.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical Significance of Tumor-associated Antigen RCAS1 Expression in Human Pancreatic Ductal Adenocarcinoma

et al. 2007

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“…RCAS1 is a tumor-associated antigen expressed on the cell surface and in the cytoplasm of various cancer cells (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). RCAS1 acts as a ligand for a putative receptor (RCAS1-R), which is expressed on various human cell lines and induces cell growth-inhibition and apoptosis (2).…”

Section: Discussionmentioning

confidence: 99%

“…It also exists in soluble form, probably through alternative splicing (2). Immunohistochemical studies show that RCAS1 is expressed in various malignant tumors, and its expression is one of the important clinicopathological parameters correlating with patient survival (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Soluble RCAS1 has also been detected in blood serum by enzyme-linked immunosorbent assay (ELISA), and is probably released from the membrane as a result of ectodomain shedding (14,15).…”

Section: Introductionmentioning

confidence: 99%

Analysis of cell cycle arrest and apoptosis induced by RCAS1

Nishinakagawa

Fujii²,

Nozaki³

et al. 2010

Int J Mol Med

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Abstract.A tumor-associated antigen RCAS1 (receptor binding cancer antigen expressed on SiSo cells) induces cell cycle arrest and apoptosis to a putative RCAS1 receptor (RCAS1-R) expressing cells such as T, B, and natural killer cells. Its expression is related with clinical poor prognosis of some malignant tumors. It is suggested that the expression of RCAS1 in tumor cells plays an important role in evasion from host immune system resulting tumor progression, invasion and metastasis. However, the mechanism of RCAS1 induced cell cycle arrest and apoptosis has not been clarified. In this study, we established a mouse L cell line transformed with tetracycline-induced rcas1 gene expression system and analyzed the RCAS1 functions. We showed that RCAS1 induced cytochrome c release and activation of caspase-3 for apoptosis. Moreover, we investigated cell cycle associated proteins and revealed that cyclin D3 decreased significantly and no change was seen in the expression levels of the other proteins. These results suggest that cyclin D3 is one of the key target molecules in the RCAS1-RCAS1-R signaling pathway.

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Core–shell structures assembled from magnetic covalent organic frameworks as a Ti4+-fixed affinity substrate for the identification of phosphopeptides in colorectal cancer serum

Chen,

Zhou,

Cao

et al. 2024

Anal Bioanal Chem

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Prognostic Significance of Receptor-Binding Cancer Antigen Expressed on SiSo Cells (RCAS1) Expression in Relation to Cadherin Expression in Patients with Colorectal Carcinoma

Cited by 9 publications

References 36 publications

Clinical Significance of Tumor-associated Antigen RCAS1 Expression in Human Pancreatic Ductal Adenocarcinoma

Clinical Significance of Tumor-associated Antigen RCAS1 Expression in Human Pancreatic Ductal Adenocarcinoma

Analysis of cell cycle arrest and apoptosis induced by RCAS1

Core–shell structures assembled from magnetic covalent organic frameworks as a Ti4+-fixed affinity substrate for the identification of phosphopeptides in colorectal cancer serum

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