Prognostic significance of red blood cell distribution width in gastrointestinal disorders

Goyal, Hemant; Lippi, Giuseppe; Gjymishka, Altin; John, Bijo K.; Chhabra, Rajiv; May, Elizabeth

doi:10.3748/wjg.v23.i27.4879

Cited by 62 publications

(50 citation statements)

References 65 publications

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“…It is a valuable measurement in many pathological diseases, ranging from sepsis to cancer, and from kidney dysfunction to cardiovascular disease, and it has also been shown in the literature to be an important inflammatory marker. [10] It has been identified as an important marker in determining the mortality rate and length of hospital stay in patients in many clinical trials. [17] In a study conducted with 322 AP patients, Gülen et al [18] considered RDW values to be significant for early prediction of prognosis in nontraumatic AP cases.…”

Section: Discussionmentioning

confidence: 99%

“…There are also a few studies in the literature reporting that the CRP/albumin ratio can be used in this respect. [9,10] The objective of this study was to evaluate the efficacy of RDW and CRP/albumin values, both of which are inexpensive, easy-to-access, and reproducible markers available from routine blood tests, in predicting the prognosis of the patients hospitalized due to AP.…”

Section: Introductionmentioning

confidence: 99%

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Significance of Red Blood Cell Distribution Width and CRP/Albumin Levels in Predicting Prognosis of Acute Pancreatitis

Yılmaz

Kandemır²

2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Acute pancreatitis (AP) is one of the major pathologies among gastrointestinal system diseases. The aim of this study was to determine the relationship between the red cell distribution width (RDW) value and the C-reactive protein (CRP)/ albumin ratio in patients with AP. METHODS: In this retrospective study, AP cases were enrolled and divided into 2 groups according to the Ranson criteria as moderate or severe pancreatitis. The RDW and CRP/albumin values, length of hospitalization and stay in the intensive care unit (ICU), and the complications experienced were compared between these 2 groups. RESULTS: A total of 264 patients were included in the study. Moderate pancreatitis was detected in 204 patients (77.2%) while severe pancreatitis was seen in 60 patients (22.8%) (p=0.081). There was no statistically significant difference in the RDW value between the groups (p=0.193). The CRP/albumin values were significantly higher in the severe pancreatitis group compared with the moderate group (p<0.001). The severe AP group also had a longer period of hospital care, both overall and in the ICU (p=0.001, p=0.047). CONCLUSION: RDW was not a specific marker for predicting prognosis in AP, but the CRP/albumin ratio is an easy-to-apply, inexpensive, and reliable marker.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Significance of Red Blood Cell Distribution Width and CRP/Albumin Levels in Predicting Prognosis of Acute Pancreatitis

Yılmaz

Kandemır²

2018

Ulus Travma Acil Cerrahi Derg

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“…However we determined a significant decrease in MCV levels in patients with colon cancer who were treated with FUFA. Red cell distribution width is known to be associated with systemic inflammation (15). Increase in RDW values have been suggested as a diagnostic and prognostic tool in colon cancer patients (16,17).…”

Section: Discussionmentioning

confidence: 99%

ASSESSMENT of HEMATOLOGICAL PARAMETERS BEFORE and AFTER ADJUVANT CHEMOTHERAPY in PATIENTS with COLORECTAL CANCER

Kasapoğlu¹,

Yozgat²,

Engın³

2019

Acta Oncol Tur.

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Bu çalışmada kolorektal kanserli hastalarda adjuvan kemoterapi tedavisi sonrasında hematolojik parametrelerdeki değişiklikleri değerlendirmeyi amaçladık. YÖNTEM ve GEREÇLER: Kolorektal kanser tanısı konan toplam 140 vakada değerlendirilmiş ve bu hastalardan 57'sine adjuvan kemoterapi verilmiştir. Adjuvan kemoterapi sonrası tam kan sayımı parametrelerindeki değişiklikler değerlendirildi. BULGULAR: Katılımcıların 67'si (% 47.9) kadın, 73'ü (% 52.1) erkek idi, yaş ortalamaları 62.13 ± 1.11 yıl idi. En sık görülen tümör yerleşimi rektumdu (% 45.7). Bu hastalardan 57'si adjuvan kemoterapi (% 40.7) aldı, en sık uygulanan kemoterapi rejimi Mayo rejimi (% 84.2) idi. Olgularımızın % 27.9'unda tanı anında metastaz vardı. Klinik takip sırasında hastaların% 10.7'sinde lokal nüks ve% 7.8'inde metastaz vardı. Hemoglobin (HGB) düzeyleri hem kan transfüzyonu yapılan hastalarda hem de yapılmayanlarda anlamlı bir düşüş gösterdi, ancak bu daha önce transfüzyonu olmayan hasta grubunda daha belirgindi (p = 0.002). Yardımcı kemoterapiyi takiben, beyaz kan hücresi değerleri (WBC), ortalama eritrosit hacimleri (MCV) ve trombosit (PLT) seviyelerinin, modifiye edici bileşenlerle (metastaz gelişimi, kemoterapi uygulama süresi, kan transfüzyonu) herhangi bir etkileşim olmadan önemli ölçüde azaldığı bulundu. (Sırasıyla p değerleri 0.002, 0.001 ve 0.001), ayrıca kırmızı hücre dağılım genişliği (RDW) önemli ölçüde artmıştır (p = 0.001). TARTIŞMA ve SONUÇ: Hgb, MCV, WBC ve trombosit seviyelerinde anlamlı bir azalma ve adjuvan kemoterapi sonrası RDW'de anlamlı bir artış vardı ve bu değişiklikler metastaz varlığından veya kemoterapi süresinden etkilenmedi. Kan parametrelerinde bu değişikliklerin hastaların prognozu ile ilişkisi ileriki çalışmalarda araştırılmalıdır. Anahtar Kelimeler: kolorektal kanser, beyaz kan hücresi değerleri, ortalama eritrosit hacmi, trombosit, kırmızı hücre dağılım genişliği ABSTRACT INTRODUCTION: In this study we aimed to evaluate the alterations in hematological parameters due to the adjuvant chemotherapy treatment in patients with colorectal cancer. METHODS: In a total of 140 cases diagnosed with colorectal cancer were evaluated and among those patients 57 received adjuvant chemotherapy. Alterations in complete blood count parameters after adjuvant chemotherapy were evaluated. RESULTS: Among participants, 67 (47.9%) were women and 73 (52.1%) were men with a mean age of 62.13 ± 1.11 years. The most common tumor localization was rectum (45.7%). Among these patients 57 received adjuvant chemotherapy (40.7%), the most frequently implemented chemotherapy regimen was Mayo regimen (84.2%). 27.9% of our cases had metastasis at the time of diagnosis. During clinical follow-up 10.7% of the patients had local relapse and 7.8% had metastasis. Hemoglobin (HGB) levels displayed a significant decrease both in patients who received blood transfusion or not, however this was more evident in the group of patients

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“…High RDW was more pronounced in patients with right-sided colon cancer [ 24 ]. High RDW was also found to be associated with an increased risk of mortality in CRC patients [ 25 ]. In CRC patients, slow bleeding from cancer is thought to cause iron deficiency anemia and stools positive for the occult blood test, and it is observed more in elderly patients.…”

Section: Screening Of Colorectal Cancermentioning

confidence: 99%

Scope of Artificial Intelligence in Screening and Diagnosis of Colorectal Cancer

Goyal

Mann

Gandhi

et al. 2020

JCM

Self Cite

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Globally, colorectal cancer is the third most diagnosed malignancy. It causes significant mortality and morbidity, which can be reduced by early diagnosis with an effective screening test. Integrating artificial intelligence (AI) and computer-aided detection (CAD) with screening methods has shown promising colorectal cancer screening results. AI could provide a “second look” for endoscopists to decrease the rate of missed polyps during a colonoscopy. It can also improve detection and characterization of polyps by integration with colonoscopy and various advanced endoscopic modalities such as magnifying narrow-band imaging, endocytoscopy, confocal endomicroscopy, laser-induced fluorescence spectroscopy, and magnifying chromoendoscopy. This descriptive review discusses various AI and CAD applications in colorectal cancer screening, polyp detection, and characterization.

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Prognostic significance of red blood cell distribution width in gastrointestinal disorders

Cited by 62 publications

References 65 publications

Significance of Red Blood Cell Distribution Width and CRP/Albumin Levels in Predicting Prognosis of Acute Pancreatitis

Significance of Red Blood Cell Distribution Width and CRP/Albumin Levels in Predicting Prognosis of Acute Pancreatitis

ASSESSMENT of HEMATOLOGICAL PARAMETERS BEFORE and AFTER ADJUVANT CHEMOTHERAPY in PATIENTS with COLORECTAL CANCER

Scope of Artificial Intelligence in Screening and Diagnosis of Colorectal Cancer

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