Prognostic significance of SATB1 in gastrointestinal cancer: a meta-analysis and literature review

Zhang, Sheng; Tong, Yi Xin; Xu, Xiangjie; Lin, Hui; Chao, Teng Fei

doi:10.18632/oncotarget.16867

Cited by 12 publications

(10 citation statements)

References 45 publications

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“…Quality assessment of the included studies was performed by 2 independent reviewers (XSX and JXY) according to REMARK (REporting recommendations for tumor MARKer prognostic studies) guideline. 9 As previously published, 10 we used the 20-item scale for quality assessment ( Table 1 ). In brief, this scale includes information on study design, assay method, outcomes and statistical analysis method.…”

Section: Methodsmentioning

confidence: 99%

The prognostic role of Gas6/Axl axis in solid malignancies: a meta-analysis and literature review

Zhang¹,

Xu²,

Yang³

et al. 2018

OTT

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BackgroundAxl is a receptor tyrosine kinase that is involved in many pathological conditions and carcinogenesis. Gas6 is the major ligand of Axl. Activation of Gas6/Axl pathway is essential for cancer development. However, its prognostic significance in solid tumors remains unclear. Therefore, we performed this meta-analysis to elucidate the prognostic impact of Axl.MethodsPublished studies on Axl or Gas6 expression and overall survival (OS) and/or disease-free survival (DFS) were searched from databases. The outcome measurement is hazard ratio (HR) for OS or DFS related to Axl/Gas6 expression. Meta-analysis was performed using RevMan. The pooled HR was calculated by fixed-/random-effect models.ResultsA total of 3,344 patients from 25 studies were included. The results of meta-analysis showed that Axl overexpression was correlated with shorter OS (HR: 2.03, p<0.0001) and DFS (HR: 1.85, p<0.0001). In subgroup analysis, Axl expression was significantly correlated with poor prognosis in hepatocellular, esophageal and lung cancer. Axl expression was associated with differentiation grade, TNM stage, lymph node and distant metastasis.ConclusionThese results suggest that Axl overexpression is correlated with poor prognosis in solid tumors. This correlation varies among different types of cancers. More studies are needed to further investigate the prognostic value of Axl.

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Section: Methodsmentioning

confidence: 99%

The prognostic role of Gas6/Axl axis in solid malignancies: a meta-analysis and literature review

Zhang¹,

Xu²,

Yang³

et al. 2018

OTT

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“…Moreover, UCA1 also could promote the proliferation and invasion of GC through sponging miR-495-3p [30]. SATB1 is a target of miR-495-3p and positively correlated with the advanced tumor node metastasis stage of GC [66]. Furthermore, UCA1 could sponge the miR-590-3p targeting cyclic adenosine monophosphate response element-binding protein 1 (CREB1), and knockdown of CREB1 inhibits the growth of human GC in vitro and in vivo [67,68].…”

Section: Gastrointestinal Cancersmentioning

confidence: 99%

Crosstalk between the lncRNA UCA1 and microRNAs in cancer

Xuan

Zhang

et al. 2019

FEBS Letters

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Long non-coding RNAs (lncRNAs) are a major subset of highly conserved non-coding RNAs (ncRNAs) that consist of at least 200 nucleotides and have limited protein-coding potential. Cumulative data have shown that lncRNAs are deregulated in many types of cancer and may control pathophysiological processes of cancer at various levels, including transcription, post-transcription and translation. Recently, lncRNAs have been demonstrated to interact with microRNAs (miRNAs), another major subset of ncRNAs, which regulate physiological and pathological processes by inhibiting target mRNA translation or promoting mRNA degradation. The lncRNA urothelial carcinomaassociated 1 (UCA1) has recently gained much attention as it is overexpressed in many types of cancer and is involved in carcinogenesis. Here, we review the crosstalk between UCA1 and miRNAs during the pathogenesis of cancer, with a focus on cancer-cell proliferation, invasion, drug resistance, and metabolism.

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“…A study performed by Zhang et al which aimed to explore the prognostic value of SATB1 in gastrointestinal cancer also probed the role of SATB1 in CRC patients (Zhang et al, 2017 ). Comparing with their studies, our study should be more specific and reliable since we only included the data that detected SATB1 expression using immunohistochemical method.…”

Section: Discussionmentioning

confidence: 99%

Prognostic and Clinicopathological Significance of SATB1 in Colorectal Cancer: A Meta-Analysis

et al. 2018

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Background: A large number of studies have reported the aberrant expression of special AT-rich sequence binding protein 1 (SATB1) in colorectal cancer (CRC). However, the role of SATB1 in CRC is still controversial. Therefore, we performed this meta-analysis to elucidate the prognostic and clinical value of SATB1 in CRC patients.Methods: We searched Web of Science, EMBASE and PubMed entirely in January 2018 to identify related articles. Pooled Hazard ratio (HR) was adopted to evaluate the prognostic value of SATB1 in CRC and odd ratio (OR) was used to assess the clinicopathological significance of SATB1 in CRC.Results: Ten eligible studies containing 7 on prognosis and 9 on clinicopathological characteristics were finally included in the present meta-analysis. Results revealed that patients with high expression of SATB1 tended to have shorter overall survival (OS) (pooled HR: 1.64, 95% CI: 1.04–2.57). Besides, we also discovered that the expression of SATB1 was associated with histologic grade (OR = 1.88, 95% CI: 1.06–3.34), distant metastasis (OR = 1.43, 95% CI: 1.11–1.85) and lymph node metastasis (OR = 1.50, 95% CI: 1.03–2.19).Conclusion: Broadly speaking, our meta-analysis demonstrated that high expression level of SATB1 was related to poor prognosis in CRC patients.

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Prognostic significance of SATB1 in gastrointestinal cancer: a meta-analysis and literature review

Cited by 12 publications

References 45 publications

The prognostic role of Gas6/Axl axis in solid malignancies: a meta-analysis and literature review

The prognostic role of Gas6/Axl axis in solid malignancies: a meta-analysis and literature review

Crosstalk between the lncRNA UCA1 and microRNAs in cancer

Prognostic and Clinicopathological Significance of SATB1 in Colorectal Cancer: A Meta-Analysis

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