Prognostic Significance of SCC Antigen in the Serum of Patients with Head and Neck Cancer

Molina, Rafael; Torres, M.D. Martínez del Valle; Moragas, M.; Perez-Villa, Jose; Filella, Xavier; Jo, Judith; Farrús, Blanca; Giménez, Núria; Traserra, J; Ballesta, Antonio M.

doi:10.1159/000217970

Cited by 28 publications

(26 citation statements)

References 6 publications

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“…SCC antigen was originally discovered as a tumor marker for cervical cancer [32], and was shown to be a prognostic factor for both cervical and head and neck cancer [33, 34]. In the case of esophageal cancer, 25–28.6% of the patients with SCC are SCC antigen positive [28, 29, 30].…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Osteopontin in Esophageal Squamous Cell Carcinoma: Comparison with Common Tumor Markers

et al. 2005

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Objective: Osteopontin (OPN) is a secreted integrin-binding glycophosphoprotein that may have a role in head and neck squamous cell carcinoma (SCC). To evaluate the clinical significance of OPN in esophageal squamous cell carcinoma (ESCC), we compared plasma OPN levels with those of common tumor markers. Methods: Preoperative plasma OPN levels were measured by enzyme immunoassay in 103 ESCC patients. Serum SCC antigen, Cyfra 21-1, and carcinoembryonic antigen (CEA) levels were also measured routinely at admission by radioimmunoassay. Results: Plasma OPN levels ranged from 82.8 to 1,980 ng/ml. High OPN level was associated with lymph node metastasis (p = 0.05), but not with tumor histology or depth of invasion. The overall survival of the patients with high OPN levels was worse than that of those with low OPN levels (p = 0.02). SCC antigen and Cyfra 21-1 levels were associated with the depth of tumor invasion, the tumor diameter, lymph node metastasis, and the overall survival, but CEA was not associated with these clinicopathological factors. Combined evaluation of OPN plus Cyfra 21-1 or OPN plus SCC antigen was useful as an independent prognostic indicator. Conclusion: Measurement of the plasma OPN level, as well as serum SCC antigen and Cyfra 21-1, may help to predict the progression of ESCC.

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Section: Discussionmentioning

confidence: 99%

Clinical Significance of Osteopontin in Esophageal Squamous Cell Carcinoma: Comparison with Common Tumor Markers

et al. 2005

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“…No correlation was evident between serum SCC Ag levels and age, or nodal metastases. In patients with primary tumors, SCC Ag levels were associated with nodal involvement and tumor location, with significantly higher levels in tumors of the nasopharynx and piriform sinus [29]. Lara and Cuyas [28] indicated for laryngeal cancer an elevated sensitivity (68%), significantly related to T, N and M stage.…”

Section: Head and Neck Cancermentioning

confidence: 97%

“…0.002) [29]. SCC Ag is an excellent marker of residual disease after primary treatment that can lead to the addition of other therapeutic procedures, when high elevated treatment SCC Ag levels indicated incomplete surgical resection (p !…”

Section: Head and Neck Cancermentioning

confidence: 99%

SCC Antigen in Malignant and Nonmalignant Squamous Lesions

Torre¹

1998

Tumor Biol

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Squamous cell carcinoma (SCC) antigen (Ag) present and expressed in normal epithelium and epithelial tissues is used primarily as tumor marker of SCC of the uterine cervix. In this review, we considered factors interfering in vitro with the collection of samples and assay procedures, benign and malignant nongynecological diseases which may be the cause of elevated serum levels of SCC Ag. Contamination with skin or saliva strongly influences SCC Ag levels. SCC Ag is elevated in several benign lesions, including pulmonary (tuberculosis, adult respiratory distress syndrome, pulmonary infiltration with eosinophilia, sarcoidosis, bronchogenic cyst) and skin (eczema, pemphigus, erythroderma epidermitis, psoriasis) diseases. Elevations are observed in SCC malignancies of the head and neck, esophagus, skin, lung, urothelium, anal canal and vulva.

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“…However, the neutral form encoded by the SCCA1 gene is found in normal and some malignant cells [5]. Clinical studies have shown that SCC is elevated in the sera of 34-59% of untreated patients [6,7] predominantly at late stages or with large tumour size [1,3,4]. A correlation between serum levels of SCC and invasion of cervical nodes was found in two studies [1,3].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Cyfra 21-1 and SCC Assays in Head and Neck Tumours

Banal¹,

Hacène²,

Berthelot-Ruff³

et al. 2001

Tumor Biology

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Patients with head and neck tumours (HNT) have a high risk of early locoregional relapse that is difficult to diagnose. This study evaluated the usefulness of the serum Cyfra 21-1 assay compared to squamous cell carcinoma antigen (SCC) assay for monitoring such patients. Three hundred and twelve HNT patients, including 204 newly diagnosed patients, were followed up for a median of 446 days with serial serum assays for SCC and Cyfra 21-1. Untreated patients showed SCC and Cyfra 21-1 serum levels correlated with each other: concentration was correlated to clinical stage, tumour size (as T1 + T2 vs. T3 + T4) and nodal status. Cyfra 21-1, but not SCC, was related to the presence of metastases and the primary tumour site, with a univariate prognostic value for disease-free survival (p = 0.015). Cox’s regression analysis showed that only Cyfra 21-1 was associated with a risk of relapse (p = 0.027). The random coefficient growth curve model applied to serial SCC and Cyfra 21-1 measurements of 111 patients showed that only Cyfra 21-1 exhibited a significant difference between patients with and without relapses. We found Cyfra 21-1 to be more closely related to initial clinical data and disease evolution than SCC, and therefore propose the use of Cyfra 21-1 for monitoring head and neck cancers.

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Prognostic Significance of SCC Antigen in the Serum of Patients with Head and Neck Cancer

Cited by 28 publications

References 6 publications

Clinical Significance of Osteopontin in Esophageal Squamous Cell Carcinoma: Comparison with Common Tumor Markers

Clinical Significance of Osteopontin in Esophageal Squamous Cell Carcinoma: Comparison with Common Tumor Markers

SCC Antigen in Malignant and Nonmalignant Squamous Lesions

Comparison of Cyfra 21-1 and SCC Assays in Head and Neck Tumours

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