Prognostic Significance of Serum and Tissue Carcinoembryonic Antigen in Patients with Gastric Adenocarcinomas

Park, Seong Hoon; Ku, Ki-Beom; Chung, Hoyoung; Yu, Wansik

doi:10.4143/crt.2008.40.1.16

Cited by 35 publications

(27 citation statements)

References 20 publications

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“…Next, we also used X-plot to determine the best cut-off value of CEA for predicting prognosis, and found it to be 7.2 ng/ml. This cutoff value was consistent with the the previous literature reported [15]. We performed multivariate regression analysis with CEA cut-off value of 7.2 ng/ ml instead of 3.4 ng/ml and found that CEA was still not an independent prognostic factor.…”

Section: Discussionsupporting

confidence: 90%

“…In previous studies, it has been reported that CEA in serum is an independent prognostic factor, while CEA in tumour tissues is not [15]. Uda et al [16] performed a retrospective study with a median follow-up of 39.6 months in 251 T2-4 GC patients.…”

Section: Discussionmentioning

confidence: 99%

“…However, because early GC and LAGC are significantly different in terms of lymph node statue and survival, the predictive value of CEA for determining LNM may be low if the two stages are not separated. In addition, whether preoperative CEA levels can predict the survival of patients with GC is still controversial [11,[14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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The significance of preoperative serum carcinoembryonic antigen levels in the prediction of lymph node metastasis and prognosis in locally advanced gastric cancer: a retrospective analysis

et al. 2020

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Background: In this study, we aimed to investigate the preoperative serum carcinoembryonic antigen (CEA) in the diagnosis of positive lymph node metastasis (LNM), and to evaluated the relationship between CEA and survival in patients with locally advanced gastric cancer (LAGC). Methods: The significance of the preoperative serum CEA level for the diagnose of LAGC and prediction of LNM was determined using the receiver operating characteristic (ROC) curve. The areas under the ROC of CEA were compared with those of other tumor markers or imaging examination including CT and MRI. Logistic regression was utilized to identify the risk factors predicting positive LNM. Independent prognosis factors were evaluated using univariate and multivariate COX regression analyses. Results:The ROC curves showed that the AUCs of CEA, CA199, and CA125 for diagnosing LAGC were 0.727, 0.594, and 0.566. When used to predict LNM, the AUC of CEA, CA199 and CA125 were 0.696, 0.531, and 0.588. Logistic regression analysis demonstrated that preoperative serum CEA were significantly associated with positive LNM. On combining imaging examination with CEA, the sensitivity and specificity were 85.3 and 79.4%, respectively, with the AUC equal to 0.853. The combination of CEA and imaging examination preformed the highest levels of AUC and sensitivity for diagnosing LNM, which is significantly higher than using either of them alone. Although patients with abnormal CEA have a poor prognosis, two models of multivariate analysis showed that CEA was not the independent prognosis factor for survival.Conclusions: CEA can be used to diagnose gastric cancer and determine whether it has LNM. Moreover, combined with CEA could improve the diagnostic sensitivity of imaging examination for lymph node involvement.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The significance of preoperative serum carcinoembryonic antigen levels in the prediction of lymph node metastasis and prognosis in locally advanced gastric cancer: a retrospective analysis

et al. 2020

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“…Currently, serum CEA is a widely used indicator in gastrointestinal cancer, as it has a significant predictive value in determining tumor stage and providing prognostic information in patients with potentially resectable gastric cancer [25,26]. However, scant evidence exists regarding the application of serum CEA levels in more advanced settings [27].…”

Section: Discussionmentioning

confidence: 99%

A Prognostic Model to Predict Clinical Outcome in Gastric Cancer Patients with Bone Metastasis

Park

Rha²,

Kim³

et al. 2011

Oncology

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Background: The clinicopathological manifestations and treatment outcomes of bone metastasis of gastric cancer are largely unknown. We delineated a prognostic model to identify different risk groups on the basis of clinical parameters. Methods: Patients who had bone metastasis at the time of diagnosis of gastric cancer (synchronous metastasis) or who developed bone metastasis during follow-up (metachronous metastasis) were retrospectively reviewed from January 1998 to May 2008. Results: Bone metastasis was identified in 203 (2.4%) of 8,633 patients: 126 patients (62%) with synchronous metastasis and 77 patients with metachronous metastasis. The median time to event was 16 months (range 4–87). As for treatment, 120 patients (59%) received systemic chemotherapy. The median survival time was 103 days (95% CI 80–126). Poor performance status [Eastern Cooperative Oncology Group 3–4; relative risk (RR) = 1.91, p = 0.011], multiple bone metastasis (RR = 2.593, p = 0.002), and abnormal carcinoembryonic antigen (RR = 1.779, p = 0.004) implied independent factors for survival. For patients who had zero to two of these factors identified, chemotherapy had a beneficial effect (175 vs. 43 days; p < 0.0001). Conclusion: We recommend that the therapeutic approach with bone metastasis be customized to facilitate the risk stratification, so as to consequently provide the most appropriate therapy for each patient.

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“…In addition, tumor markers and venous invasion were significantly associated with a high GAR. Previous studies have indicated that these two characteristics are associated increased angiogenesis, lymph node metastasis, and distant metastasis in GC patients 16, 17, 18, 19, 20. In fact, OS in the high GAR group was significantly poorer than that in the low GAR group.…”

Section: Discussionmentioning

confidence: 93%

Preoperative globulin‐to‐albumin ratio predicts outcome after curative resection in patients with gastric cancer

Shioiri

Ishizuka

Shibuya

et al. 2018

Annals of Gastroent Surgery

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AimThe globulin‐to‐albumin ratio (GAR) is useful for prognostication of patients with various cancers. However, the significance of GAR in gastric cancer (GC) remains unclear. Our purpose was to investigate the relationship between the GAR and outcome after curative resection in GC patients.MethodsThree‐hundred and seventy‐six patients who had undergone curative resection for GC were retrospectively reviewed. Univariate and multivariate analyses using the Cox proportional hazard model were performed to detect clinical characteristics that correlated with overall survival (OS), and their cut‐off values were identified using receiver operating characteristic (ROC) curve analyses. Kaplan–Meier analysis and log‐rank test were used for comparison of OS and relapse‐free survival (RFS).ResultsMultivariate analysis using 17 clinical characteristics selected by univariate analyses revealed that GAR (>0.80/≤0.80) was significantly associated with OS (hazard ratio [HR], 2.305; 95% CI, 1.122‐4.735; P = 0.023), as well as lymph node metastasis (presence/absence) (HR, 2.417; 95% CI, 1.077‐5.426; P = 0.032), neutrophil‐to‐lymphocyte ratio (>2.7/≤2.7) (HR, 2.368; 95% CI, 1.138‐4.930; P = 0.002), and serosal invasion (presence/absence) (HR, 3.443; 95% CI, 1.048‐11.31; P = 0.042). Kaplan–Meier analysis and log‐rank test demonstrated that the OS and RFS of patients with a high GAR (>0.80) were significantly poorer than those with low GAR (≤0.80).ConclusionsThe GAR is a useful predictor of postoperative outcome among GC patients undergoing curative resection.

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Prognostic Significance of Serum and Tissue Carcinoembryonic Antigen in Patients with Gastric Adenocarcinomas

Cited by 35 publications

References 20 publications

The significance of preoperative serum carcinoembryonic antigen levels in the prediction of lymph node metastasis and prognosis in locally advanced gastric cancer: a retrospective analysis

The significance of preoperative serum carcinoembryonic antigen levels in the prediction of lymph node metastasis and prognosis in locally advanced gastric cancer: a retrospective analysis

A Prognostic Model to Predict Clinical Outcome in Gastric Cancer Patients with Bone Metastasis

Preoperative globulin‐to‐albumin ratio predicts outcome after curative resection in patients with gastric cancer

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