Prognostic Significance of Serum Biochemistry Profile in Children With Severe Acute Malnutrition

Verma, Ganesh K; Yadv, Rajesh K; Chand, Ramesh; Khan, Imran; Katiyar, Shashi Bhushan S; Singh, Mukeshvir

doi:10.7759/cureus.31266

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…Children with malnutrition undergo a slowing down of organ systems owing to physiological and metabolic changes. [ 26 ] The presence of increased muscle tone, muscle spasms, and involuntary movements, which increase energy expenditure, might be the additional factors explaining this relationship.…”

Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study Examining the Relationship Between Malnutrition and Gross Motor Function in Cerebral Palsy

Bharti,

Dwivedi,

Gupta

et al. 2024

Cureus

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Introduction Cerebral palsy (CP) characterizes a range of permanent, nonprogressive symptoms of postural and motor dysfunction caused by an insult to the developing central nervous system in a fetus or an infant. CP manifests early in life, often within the first two to three years of age. CP is associated with poor growth, that is the deviation from the normal growth parameters. The prevalence of CP ranges from 2.0 to 3.5 per 1000 live births in high-income countries which is comparable to the estimates from low-income countries. Antenatal and perinatal insults are among the most commonly reported causes of CP; however, a large number of cases do not have an identifiable etiology of CP. The current study aims to examine the relationship between malnutrition and gross motor function in children with CP. Materials and Methods This study was conducted at the Department of Pediatrics and Neonatology, Nehru Hospital, Baba Raghav Das (BRD) Medical College, Gorakhpur (UP) over a period of one year (August 2020 to July 2021) after obtaining ethical clearance from the College Research Council. Children of age 1-15 years with CP attending the pediatric outpatient and inpatient departments were enrolled as the study participants after obtaining informed consent from a legal guardian. Assessment of motor function was done using the gross motor function classification system (GMFCS). Associations of malnutrition across levels of gross motor function were tested using Chi-square or Fisher’s exact test whichever was applicable. Statistical significance was set at p < 0.05 as significant. Data was analyzed using IBM SPSS Statistics for Windows, Version 21 (Released 2012; IBM Corp., Armonk, New York, United States). Result We analyzed 110 children with a diagnosis of CP (median age 6.5 years, interquartile range (IQR) 4.4-9.0 years). The majority (65/110; 59%) of the patients were male, and 68 (61.8%) delivered at term gestation. The most common presenting symptom among children with CP was seizures (79/110; 72.3%), the second most common being delayed milestones among 73 (66.8%), followed by difficulty in breathing among 63 (57.5%). The association between the anthropometric index of participants and GMFCS was found to be highly significant. Conclusion Most CP patients were facing gross motor disturbances. Spastic type of CP was most frequent, and more than half of the patients experienced feeding difficulty. A statistically significant association was found between gross motor functioning and the prevalence of malnutrition and stunting.

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Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study Examining the Relationship Between Malnutrition and Gross Motor Function in Cerebral Palsy

Bharti,

Dwivedi,

Gupta

et al. 2024

Cureus

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“…Within the developing regions, one out of every five children experiences undernourishment, and this condition is linked to 50% of child mortalities on a global scale [2]. The mortality rate associated with SAM among children below the age of 5 exhibits a range between 30% and 50%, with malnutrition being the primary or contributing factor in the majority of child fatalities with comorbidities [3]. In India, as per the recent National Family Health Survey-5 (NFHS-5) (2019-2021), the prevalence of SAM remains alarmingly high at 7.7%.…”

Section: Introductionmentioning

confidence: 99%

Comparison of biochemical and anthropometric parameters in complicated and uncomplicated severe acute malnutrition among children aged 6 to 59 months: a cross-sectional study

Mishra,

Tripathi,

Singh

et al. 2023

Exploration of Medicine

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Aim: The frequency of severe acute malnutrition (SAM) is the highest in India. Although it should receive more attention, severe anemia is one of the comorbidities that increases mortality in children who are severely undernourished. In SAM children, the liver function test (LFT), kidney function test (KFT), and complete blood count (CBC) are deranged, but their correlation with the prognosis is not well defined. The aim was to describe the anthropometric assessment and biochemical profile of children with SAM. Methods: This cross-sectional cohort study was performed at the Departments of Paediatrics and Biochemistry at G.S.V.M. Medical College, Kanpur, and at the Department of Biotechnology at Amity University Rajasthan, Jaipur. One hundred and six patients with SAM were enrolled; 53 were grouped as complicated SAM (Group 1) (dehydration and severe dehydration) and 53 were diagnosed as non-complicated SAM (Group 2). Results: Group II had significantly higher mean values for height, weight, mid-upper arm circumference (MUAC), head circumference, and body mass index (BMI) for age percentile compared to Group I, with P-values of 0.001. Group I had a significantly lower level of hemoglobin (8.86 g/dL ± 2.21 g/dL) compared to Group II (10.0 g/dL ± 1.83 g/dL) with a P-value of 0.003. The difference in the frequency of anemia between the groups was statistically significant, with a P-value of 0.026. Anemia significantly increased the risk of complicated SAM with an odds ratio of 2.60 [95% confidence interval (CI), 1.07–6.31, P = 0.001]. Conclusions: This study suggests that there may be a significant relationship between anemia and the development of complications in high-risk children with SAM.

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Fluid intake, fiber consumption, and physical activity related to constipation among elderly, which one is more important? A cross-sectional study in Iran

Safarnavadeh,

Salehi,

Mahmoodi

2024

Nor. Afr. J. Food Nutr. Res.

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Background: Chronic constipation is a common, self-reported, and symptom-based disorder which can significantly influence an individual’s health-related quality of life and imposes several financial costs. Aims: The present study aimed to evaluate the effect of water consumption, fiber intake, and physical activity (PA) on constipation, and which one is more critical by considering the mediating effect of BMI. Subjects and Methods: This cross-sectional study involved 400 older adults in 2019 referring to the comprehensive health service centers in Karaj, the capital of Alborz province. The data were collected using the questionnaires of demographic and anthropometric characteristics, PASE (Physical activity for elderly), fluid intake, FFQ (Food Frequency questionnaire), Wexner constipation, and Persian lifestyle questionnaire analyzed using SPSS and LISREL software. Results: Based on the final fitted model, PA is the most critical constipation-related factor compared to the fluid intake and fiber consumption. In addition, fiber consumption is the second crucial factor affecting constipation, and there is a negative association between constipation and fiber intake. Conclusion: As price is one of the barriers to fiber consumption among the elderly, the recommendation to do physical activity such as walking to solve constipation is efficient and inexpensive for individuals with different socio-economic status. Keywords: Physical activity, Wexner constipation, fiber consumption, elderly, Iran.

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Prognostic Significance of Serum Biochemistry Profile in Children With Severe Acute Malnutrition

Cited by 4 publications

References 13 publications

A Cross-Sectional Study Examining the Relationship Between Malnutrition and Gross Motor Function in Cerebral Palsy

A Cross-Sectional Study Examining the Relationship Between Malnutrition and Gross Motor Function in Cerebral Palsy

Comparison of biochemical and anthropometric parameters in complicated and uncomplicated severe acute malnutrition among children aged 6 to 59 months: a cross-sectional study

Fluid intake, fiber consumption, and physical activity related to constipation among elderly, which one is more important? A cross-sectional study in Iran

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