Prognostic significance of serum chemerin levels in patients with non-small cell lung cancer

Xu, Chunhua; Yang, Yang; Wang, Yuchao; Yan, Jun; Qian, Liwei

doi:10.18632/oncotarget.14956

Cited by 39 publications

(43 citation statements)

References 19 publications

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“…When compared to the adjacent Barrett’s tissue, the malignant tissues of esophageal adenocarcinoma were reported to have high chemerin expression, 49 , 50 which confirmed an association between overexpression of chemerin and chemR23 and a more invasive esophageal squamous cell carcinoma. Recently, Xu et al 51 reported that chemerin expression in serum may be considered as a serum biomarker for diagnosis and prognosis in non-small-cell lung cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Expression of chemerin correlates with a poor prognosis in female breast cancer patients

El-Sagheer¹,

Gayyed²,

Ahmad³

et al. 2018

BCTT

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ObjectiveChemerin was reported to regulate adipogenesis, metabolism, and immunity. But, its relation to cancer remains controversial. In breast cancer, chemerin expression has only been studied in serum, however, its expression in tissue, to our knowledge, has not been studied. The aim of this study was to investigate chemerin expression in breast cancer tissue in comparison to the adjacent normal tissue, and to assess its relationship to disease prognosis.MethodsWe examined chemerin expression in tissue with immunohistochemistry and analyzed the association of chemerin expression with the patients’ clinical and pathological characteristics to determine its role as a predictor of the disease and its relation to disease prognosis.ResultsWe detected a significantly higher expression of chemerin in the malignant vs the non-cancerous tissue specimens in 30/53, (56%) patients, (P=0.001). Moreover, its expression was significantly higher in the metastatic lymph nodes in comparison to the tumor tissues, (P=0.01). Chemerin expression was significantly correlated with weight (r=0.256, P=0.04), body mass index (r=0.233, P=0.03), tumor size (r=0.235, P=0.03), lymph node metastasis (r=0.265, P=0.045), distant metastasis (r=0.267, P=0.02), and tumor grading, (r=0.421, P=0.004), while it was inversely significantly correlated with estrogen receptor and progesterone receptor expression in malignant breast tissues (P=0.038, r=−0.437, and P=0.047, r=–0.316), respectively. The area under the receiver operating characteristic curve for chemerin as a predictor of breast cancer was 0.82, (P<0.001, sensitivity 89%, and specificity 69%). The Kaplan–Meier survival curves revealed that patients with higher chemerin expression had worse overall survival in comparison to those with a lower chemerin expression, (P=0.001).ConclusionOur results revealed higher chemerin expression in malignant vs adjacent normal breast tissue and lend support to a presumable role of chemerin tissue expression as an independent predictor of poor prognosis in breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Expression of chemerin correlates with a poor prognosis in female breast cancer patients

El-Sagheer¹,

Gayyed²,

Ahmad³

et al. 2018

BCTT

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“…This adipokine is involved in metabolism and immune reactions. Recently, the potential role of chemerin in cancerogenesis was described [37,38]. Higher chemerin levels were observed in non-small cell lung cancer patients compared with healthy controls and were associated with advanced TNM stage [37].…”

Section: Prace Oryginalnementioning

confidence: 99%

“…Recently, the potential role of chemerin in cancerogenesis was described [37,38]. Higher chemerin levels were observed in non-small cell lung cancer patients compared with healthy controls and were associated with advanced TNM stage [37]. Elevated serum levels of chemerin were also determined in gastric cancer and colorectal cancer patients [38].…”

Section: Prace Oryginalnementioning

confidence: 99%

Stężenia adipokin u mężczyzn z rakiem prostaty i z łagodnym przerostem prostaty

Siemińśka

Borowski²,

Marek

et al. 2015

Endokrynologia Polska

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“…Although the treatment of lung cancer has made great breakthroughs in recent decades, traditional chemotherapeutic drugs lacked specific targeting specificity for NSCLC, or had toxic side effects on patients and limited efficacy [7]. The result of the patients' long-term survival did not show significant improvements [8,9]. Therefore, it was necessary and urgent to explore new therapeutic targets for NSCLC.…”

Section: Introductionmentioning

confidence: 99%

Tripartite motif containing 35 contributes to the proliferation, migration, and invasion of lung cancer cellsin vitroandin vivo

Zhang

et al. 2020

Bioscience Reports

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The tripartite motif (TRIM) family is a family of proteins with highly conserved domains. Previous researches have suggested that the members of TRIM family proteins played a crucial role in cancer development and progression. Our study explored the relationship between TRIM35 and non-small cell lung cancer (NSCLC). The study showed that the expression of TRIM35 was increased in NSCLC samples, and patients with high expression of TRIM35 had a poor clinical prognosis. Overexpression of TRIM35 in NSCLC cell line H460 promoted cell proliferation, migration, and invasion, knockdown of TRIM35 produced an opposite result in A549 and H1299 cell lines. In vivo study further confirmed that overexpression of TRIM35 promoted tumor formation. The RNA-seq analysis suggested that TRIM35 might promote lung cancer proliferation, migration, and invasion by regulating cancer-associated functions and signaling pathways. Hence, we identified TRIM35 played a significant role in tumoral growth and was a potential diagnosis and prognosis target for lung cancer.

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Prognostic significance of serum chemerin levels in patients with non-small cell lung cancer

Cited by 39 publications

References 19 publications

Expression of chemerin correlates with a poor prognosis in female breast cancer patients

Expression of chemerin correlates with a poor prognosis in female breast cancer patients

Stężenia adipokin u mężczyzn z rakiem prostaty i z łagodnym przerostem prostaty

Tripartite motif containing 35 contributes to the proliferation, migration, and invasion of lung cancer cellsin vitroandin vivo

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