Prognostic significance of serum creatinine concentration for in-hospital mortality in patients with acute myocardial infarction who underwent successful primary percutaneous coronary intervention (from the Heart Institute of Japan Acute Myocardial Infarction [HIJAMI] Registry)

Yamaguchi, Junichi; Kasanuki, Hiroshi; Ishii, Yasuhiro; Yagi, Minoru; Ogawa, Hiroshi; Fujii, Shinya; Koganei, Hiroshi; Okada, Hisayuki; Kimura, Hirotaka; Horie, Toshinobu; Haze, Kazuo; Sumiyoshi, Tetsuya; Honda, Takashi

doi:10.1016/j.amjcard.2004.02.065

Cited by 53 publications

(43 citation statements)

References 14 publications

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“…We believe that immediate risk stratification by the serum creatinine level for the management of AMI patients has significant meaning, especially in the setting of primary PCI, because the assessment of serum creatinine on presentation can induce the interventional cardiologist to pay attention to reducing the volume of contrast media that will be deleterious to the kidney. In routine clinical practice, together with our previous data that elucidated that renal insufficiency leads to poor in-hospital prognosis even in AMI patients undergoing successful PCI, 30 we need to immediately start making efforts to avoid worsening renal function after admission in order to improve the outcome of AMI patients.…”

Section: Discussionmentioning

confidence: 99%

Serum Creatinine on Admission Predicts Long-Term Mortality in Acute Myocardial Infarction Patients Undergoing Successful Primary Angioplasty

Yamaguchi

Kasanuki

Ishii

et al. 2007

Circ J

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Background Data about the long-term mortality of acute myocardial infarction (AMI) patients with renal insufficiency who received sufficient early revascularization are scant, so the present study evaluated the impact of serum creatinine levels on the long-term mortality in patients with AMI undergoing successful primary percutaneous coronary intervention (PCI). Methods and ResultsThe Heart Institute of Japan Acute Myocardial Infarction (HIJAMI) registry has 3,021 consecutive AMI patients. Primary PCI was attempted in 1,451 patients and successful revascularization was obtained in 1,359 patients (93.6%). An elevated serum creatinine level, defined as creatinine ≥1.2 mg/dl, was observed in 216 patients (15.8%). Univariate analyses showed statistical differences between normal and elevated serum creatinine groups in age, gender, hypertension, previous myocardial infarction, number of diseased vessels and Killip class. During a median follow-up period of 39 [32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] months, the event-free survival rate was lower in elevated creatinine group than normal creatinine group. Multivariate Cox proportional hazards model showed that serum creatinine level was an independent predictor of long-term mortality (adjusted hazard ratio 1.43 [95% confidence interval 1.03-1.99]). Conclusion The serum creatinine level on admission in patients with AMI predicts long-term mortality, even in those with successful primary PCI. (Circ J 2007; 71: 1354 -1359

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Section: Discussionmentioning

confidence: 99%

Serum Creatinine on Admission Predicts Long-Term Mortality in Acute Myocardial Infarction Patients Undergoing Successful Primary Angioplasty

Yamaguchi

Kasanuki

Ishii

et al. 2007

Circ J

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“…4,5,9) Chronic kidney disease is a well-established independent risk of all-cause death and cardiovascular events, such as heart failure, MI, stroke, and cardiovascular death not only in hypertensive patients, but also in patients with coronary artery disease, and the general population. Even a majority of previous studies concerning patients with acute coronary syndrome have shown that CKD or renal dysfunction is associated with death, cardiovascular events, and major bleeding during the admission period or long-term follow-up period.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6] On the other hand, cardiorenal anemia syndrome, in which the simultaneous presence of CKD, anemia, and heart failure creates pathological reciprocal connections, thereby resulting in an adverse synergistic impact on morbidity and mortality, is now attracting more attention. 7,8) However, few data are available concerning the impact of CKD and anemia on clinical outcomes among AMI patients undergoing primary percutaneous coronary intervention (PCI) in Japan, 9,10) and in terms of CKD concomitant with anemia, only the recent report from Matsue and colleagues has examined the longterm prognostic impact of CKD/anemia combination after hospital discharge in Japanese AMI patients. 10) network for heart diseases in Kyoto.…”

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Prognostic Impact of Chronic Kidney Disease and Anemia at Admission on In-Hospital Outcomes After Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction

et al. 2014

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SummaryCardiorenal anemia syndrome has recently been receiving greater attention; however, data regarding the relationship between chronic kidney disease (CKD)/anemia on presentation and in-hospital outcome in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) are still limited in Japan.A total of 1,447 primary PCI-treated AMI patients were classified into 4 groups according to the presence of CKD and/or anemia on hospital admission (with CKD/with anemia n = 222, with CKD/without anemia n = 299, without CKD/with anemia n = 151, without CKD/without anemia n = 775). Angiographic acute results of primary PCI were similar among the 4 groups. The patients with CKD had a significantly higher in-hospital overall mortality rate than the patients without CKD, and in the presence or absence of CKD, patients with anemia tended to have a higher in-hospital mortality rate than the patients without anemia. According to a multivariate analysis, anemia on admission was found to be an independent predictor of in-hospital mortality, whereas admission CKD and admission eGFR were statistically not independent predictors. Moreover, the multivariable adjusted odds ratio of in-hospital death in AMI patients with CKD alone was 1.855 (95% CI 0.929-3.706), and that in AMI patients with CKD/with anemia was 3.384 (95% CI 1.697-6.748).These results suggest that among real-world, unselected Japanese AMI patients undergoing primary PCI, the combination of CKD and anemia on admission confers significant adverse effects on in-hospital mortality. (Int Heart J 2014; 55: 301-306)

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“…10 However, renal insufficiency is associated with a worse clinical outcome in patients with coronary artery disease including AMI. [11][12][13][14][15][16] It is also unclear whether successful PCI provides a better prognosis of AMI even in patients Circulation Journal Vol.72, February 2008 with renal insufficiency.The aims of this study were: (1) to determine the association between renal insufficiency and the risk of unsuccessful primary PCI in AMI patients; and (2) to evaluate the correlation between unsuccessful primary PCI and the clinical outcomes at various levels of renal function. …”

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confidence: 99%

Association of Glomerular Filtration Rate With Unsuccessful Primary Percutaneous Coronary Intervention and Subsequent Mortality in Patients With Acute Myocardial Infarction From the HIJAMI Registry

Koganei

Kasanuki

Tsurumi

2008

Circ J

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umerous randomized trials have successfully demonstrated the beneficial effects of early percutaneous coronary intervention (PCI) for patients with acute myocardial infarction (AMI). [1][2][3] However, most patients with complications of renal insufficiency were excluded from randomized trials; therefore, the clinical effects of PCI for these patients have not been determined.In the past decade, patients with end-stage renal disease were associated with a decreased procedural success rate. [4][5][6] The development of device technology has provided better procedural outcomes after PCI in such patients 7-9 ; however, little is known regarding the impact of varying degrees of renal insufficiency on the success rate of emergency PCI in patients with AMI.As noted in a recent study, the success of PCI is a prime determinant of the clinical outcome of patients with AMI. 10 However, renal insufficiency is associated with a worse clinical outcome in patients with coronary artery disease including AMI. [11][12][13][14][15][16] It is also unclear whether successful PCI provides a better prognosis of AMI even in patients Circulation Journal Vol.72, February 2008 with renal insufficiency.The aims of this study were: (1) to determine the association between renal insufficiency and the risk of unsuccessful primary PCI in AMI patients; and (2) to evaluate the correlation between unsuccessful primary PCI and the clinical outcomes at various levels of renal function. Methods Study PopulationThe subjects of the present study were selected from the Heart Institute of Japan Acute Myocardial Infarction Registry (HIJAMI) database. Full details of the HIJAMI registry have been described elsewhere. 17 In brief, HIJAMI is a multicenter prospective cohort of consecutive patients with AMI who were admitted within 48 h after the onset of symptoms. Between January 1999 and July 2001, 3,021 consecutive patients from 17 participating hospitals in Japan were registered. As HIJAMI was meant for observational purposes, treatment strategies, such as drug therapies and early reperfusion treatment, were used at the discretion of the physician responsible at each hospital. Clinical and angiographic data, including the patients' demographics, coronary risk factors, therapeutic modalities, complications, number of diseased vessels, infarct-related arteries, PCI strategies, laboratory data and in-hospital outcomes were prospectively collected using a standardized case report form. Serum creatinine concentrations and C-reactive protein were measured at each site immediately after admis-

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Prognostic significance of serum creatinine concentration for in-hospital mortality in patients with acute myocardial infarction who underwent successful primary percutaneous coronary intervention (from the Heart Institute of Japan Acute Myocardial Infarction [HIJAMI] Registry)

Cited by 53 publications

References 14 publications

Serum Creatinine on Admission Predicts Long-Term Mortality in Acute Myocardial Infarction Patients Undergoing Successful Primary Angioplasty

Serum Creatinine on Admission Predicts Long-Term Mortality in Acute Myocardial Infarction Patients Undergoing Successful Primary Angioplasty

Prognostic Impact of Chronic Kidney Disease and Anemia at Admission on In-Hospital Outcomes After Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction

Association of Glomerular Filtration Rate With Unsuccessful Primary Percutaneous Coronary Intervention and Subsequent Mortality in Patients With Acute Myocardial Infarction From the HIJAMI Registry

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