Prognostic significance of serum inflammation indexes in different Lauren classification of gastric cancer

Yin, Xin; Fang, Tianyi; Wang, Yimin; Wang, Yufei; Zhang, Daoxu; Li, Chunfeng; Xue, Yingwei

doi:10.1002/cam4.3706

Cited by 17 publications

(16 citation statements)

References 47 publications

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“…However, chemotherapy could lead to serious side effects, high drug resistance, and treatment failure (6). Interest has particularly raised toward phytochemicals and naturally occurring compounds present in dietary natural products for gastric cancer treatment purposes -thanks to low toxicity and higher tolerance rate of plant-derived phytochemicals (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Effects of Syringic Acid on Apoptosis, Inflammation, and AKT/mTOR Signaling Pathway in Gastric Cancer Cells

et al. 2021

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Gastric cancer is one of the most common cancer and deadly disease worldwide. Despite substantial advances made in the treatment of gastric cancer, existing therapies still encounter bottlenecks. Chemotherapy, for instance, could lead to serious side effects, high drug resistance and treatment failure. Phytochemical-derived compounds from plants offer novel strategies as potent drug molecules in cancer therapy. Given the low toxicity and higher tolerance rate of naturally occurring compounds, the present study evaluated the effects of syringic acid on cytotoxicity, oxidative stress, mitochondrial membrane potential, apoptosis, and inflammatory responses in gastric cancer cell line (AGS). AGS cells were treated with various concentrations (5–40 μg/mL) of syringic acid for 24 h, after which cytotoxicity was analyzed. Reactive Oxygen Species (ROS), antioxidant enzyme activities, mitochondrial membrane potential (MMP, Δψm), cell morphologies, the expression of apoptotic markers and protein expression patterns were also investigated. Results indicated that syringic acid-treated cells developed anti-cancer activities by losing MMP, cell viability, and enhancing intracellular ROS. Syringic acid selectively developed apoptosis in a dose-dependent manner via enhanced regulation of caspase-3, caspase-9 and Poly ADP-ribose Polymerase (PARP) whereas decreasing the expression levels of p53 and BCL-2. Syringic acid also lowered activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) whereas Thio Barbituric Acid Reactive Substances (TBARS) increased. Syringic acid suppressed gastric cancer cell proliferation, inflammation, and induced apoptosis by upregulating mTOR via AKT signaling pathway. The study suggests syringic acid may constitute a promising chemotherapeutic candidate for gastric cancer treatment. Our study is the first report on the anti-cancer effects of syringic acid against gastric cancer cells via apoptosis, inhibition of inflammation, and the suppression of the mTOR/AKT signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Effects of Syringic Acid on Apoptosis, Inflammation, and AKT/mTOR Signaling Pathway in Gastric Cancer Cells

et al. 2021

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“…As a part of tumor immunity, the peripheral blood immune system also has a significant effect on tumor progression. Our previous studies have confirmed that the inflammatory index plays an important role in the early diagnosis of GC and the evaluation of the outcome of GC patients with different Lauren classification[ 13 , 14 ]. In addition, in liver metastases, different tumor growth pattern subtypes have different levels of lymphocyte infiltration, indicating that they have different immune states in the tumor microenvironment[ 15 ].…”

Section: Introductionmentioning

confidence: 79%

“…This evidence shows that INF can effectively help clinical experts predict the recurrence pattern and prognosis of GC patients. In addition, with the great achievements of tumor immunotherapy, it has been found that the tumor microenvironment and immune inflammatory response in peripheral blood can effectively reduce the impact of GC heterogeneity, providing more comprehensive information for the personalized treatment of patients[ 14 , 18 ]. This study was aimed at investigating the peripheral blood immune response is great value to different INF types GC patients in evaluating prognosis and individualized chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of serum inflammation indices for different tumor infiltrative pattern types of gastric cancer

Wang¹,

Yin²,

Fang³

et al. 2022

WJGO

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BACKGROUND Inflammatory indices are considered to be potential prognostic biomarkers for patients with gastric cancer (GC). However, there is no evidence defining the prognostic significance of inflammatory indices for GC with different tumor infiltrative pattern (INF) types. AIM To evaluate the significance of inflammatory indices and INF types in predicting the prognosis of patients with GC. METHODS A total of 962 patients who underwent radical gastrectomy were retrospectively selected for this study. Patients were categorized into the expansive growth type (INFa), the intermediate type (INFb), and the infiltrative growth type (INFc) groups. The cutoff values of inflammatory indices were analyzed by receiver operating characteristic curves. The Kaplan–Meier method and log-rank test were used to analyze overall survival (OS). The chi-square test was used to analyze the association between inflammatory indices and clinical characteristics. The independent risk factors for prognosis in each group were analyzed by univariate and multivariate analyses based on logistic regression. Nomogram models were constructed by R studio. RESULTS The INFc group had the worst OS ( P < 0.001). The systemic immune-inflammation index ( P = 0.039) and metastatic lymph node ratio (mLNR) ( P = 0.003) were independent risk factors for prognosis in the INFa group. The platelet-lymphocyte ratio (PLR) ( P = 0.018), age ( P = 0.026), body mass index ( P = 0.003), and postsurgical tumor node metastasis (pTNM) stage ( P < 0.001) were independent risk factors for prognosis in the INFb group. The PLR ( P = 0.021), pTNM stage ( P = 0.028), age ( P = 0.021), and mLNR ( P = 0.002) were independent risk factors for prognosis in the INFc group. The area under the curve of the nomogram model for predicting 5-year survival in the INFa group, INFb group, and INFc group was 0.787, 0.823, and 0.781, respectively. CONCLUSION The outcome of different INF types GC patients could be assessed by nomograms based on different inflammatory indices and clinicopathologic features.

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“…As a complex disease that originates from the interplay between environment and host-related issues, the pathogenesis of GC is induced by many hazard factors, including Helicobacter pylori (Hp) infection, alcohol drinking, irregular diet, and genetics (2)(3)(4). The majority of GCs are adenocarcinomas, and can divided into intestinal and diffuse subtypes based on the Lauren classification system (5,6). Although traditional treatments comprise surgical resection and chemotherapy for patients with GC, their overall benefits have been limited (7).…”

Section: Introductionmentioning

confidence: 99%

Chromobox 4 (CBX4) promotes tumor progression and stemness via activating CDC20 in gastric cancer

Chen

Wang

et al. 2022

J Gastrointest Oncol

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Background: The Chromobox homolog 4 (CBX4) has been found to be overexpressed in multiple malignancies. However, the associations between CBX4 and gastric cancer (GC) have remained unclear. This study aimed to determine the biological roles of CBX4 in GC and identify effective therapeutic targets. Methods:The 3-(4,5-dimethylthiazol-2-yl) (MTT) assays were used to screen CBX family members.Differential analysis was utilized to evaluate the CBX4 levels. Kaplan-Meier analysis was used to perform prognostic analysis. Western blotting assay, quantitative polymerase chain reaction (qPCR) assay and immunohistochemistry (IHC) were used to assess CBX4 expressions. Colony formation assay, Cell Counting Kit-8 (CCK-8) assay, and Transwell assay were used to assess progression features of cells. The tail vein injection model was utilized to determine the metastatic efficacy of GC cells. Tumor sphere formation assay was used to assess tumor stemness maintenance ability. Chromatin immunoprecipitation (ChIP)-qPCR assay was used to evaluate the associations between CBX4 and CDC20. A subcutaneous tumor model was used to assess the in vivo growth ability of GC. Results:The MTT assay revealed that only CBX4 inhibition could lead to notable restriction of GC growth, as compared to others. Differential analysis suggested that CBX4 was upregulated in tumor samples relative to normal tissues. Less favorable overall survival (OS) outcomes were noticed in GC patients with high CBX4 in comparison to those with low CBX4. High CBX4 could notably enhance cell proliferation capacity, migration ability, and in vivo metastatic efficacy. Gene set enrichment analysis (GSEA) indicated the relationships between CBX4 and GC stemness, and CBX4 overexpression could remarkably elevate self-renewal ability of GC cells. In addition, CBX4 could mainly promote CDC20 messenger RNA (mRNA) levels, and targeting CBX4 suppressed the relative CDC20 levels. The ChIP-qPCR assay further demonstrated that CBX4 coordinated with H3K4me3 to bind at the CDC20 promoter region. Additionally, CBX4 depended on CDC20 to drive GC growth. Lastly, downregulated CBX4 could notably inhibit the growth of GC in vivo.Conclusions: This study highlights the oncogenic roles of CBX4 in GC. CBX4 activates CDC20 to maintain stemness features of GC, thereby creating therapeutic vulnerabilities in the treatment of GC.

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Prognostic significance of serum inflammation indexes in different Lauren classification of gastric cancer

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 17 publications

References 47 publications

Effects of Syringic Acid on Apoptosis, Inflammation, and AKT/mTOR Signaling Pathway in Gastric Cancer Cells

Effects of Syringic Acid on Apoptosis, Inflammation, and AKT/mTOR Signaling Pathway in Gastric Cancer Cells

Prognostic significance of serum inflammation indices for different tumor infiltrative pattern types of gastric cancer

Chromobox 4 (CBX4) promotes tumor progression and stemness via activating CDC20 in gastric cancer

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