Prognostic significance of serum thymidine phosphorylase concentration in esophageal squamous cell carcinoma

Shimada, Hideaki; Takeda, Akihiko; Shiratori, Tooru; Nabeya, Yoshihiro; Okazumi, Shinichi; Matsubara, Hisahiro; Funami, Yutaka; Hayashi, Hideki; Gunji, Yoshio; Kobayashi, Susumu; Suzuki, Takao; Ochiai, Takenori

doi:10.1002/cncr.10418

Cited by 42 publications

(30 citation statements)

References 55 publications

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“…A landmark study in 2002 had concluded that SdThdPase (s-thymidine phosphorylase), a potent angiogenic factor, is markedly elevated in patients with advanced esophageal squamous cell carcinoma [13]. This enzyme is produced by tumor cell lines and is intimately associated with neovascularization, a hallmark of tumor progression and metastasis [14,15].…”

Section: Discussionmentioning

confidence: 98%

Thrombocytosis and Raised CRP Levels Predicts Advanced Stage in Esophageal Carcinoma

Verma

Thiagarajan

Gupta

et al. 2015

J Gastrointest Canc

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Section: Discussionmentioning

confidence: 98%

Thrombocytosis and Raised CRP Levels Predicts Advanced Stage in Esophageal Carcinoma

Verma

Thiagarajan

Gupta

et al. 2015

J Gastrointest Canc

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“…Elevated expression of TP protein and mRNA is observed in various cancers and is associated with poor prognosis (12,13,17,19,21). TP is also overexpressed in NPC specimens and is regulated by hnRNP K in NPC cells.…”

Section: Discussionmentioning

confidence: 99%

Heterogeneous Ribonucleoprotein K and Thymidine Phosphorylase Are Independent Prognostic and Therapeutic Markers for Nasopharyngeal Carcinoma

Chen¹,

Tsang²,

Li³

et al. 2008

Clinical Cancer Research

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Purpose: Heterogeneous ribonucleoprotein K (hnRNP K) regulates thymidine phosphorylase (TP) mRNA stability. The aim of the present study was to analyze hnRNP K and TP expression in nasopharyngeal carcinoma (NPC) and to evaluate the prognostic and therapeutic potential of these two markers. Experimental Design: We analyzed hnRNP K and TP expression immunohistochemically in 121 clinically proven NPC cases. Statistical analyses were applied to correlate cytoplasmic hnRNP K with elevated TP expression and determine the prognostic significance of these parameters. The therapeutic implication of elevatedTP expression was determined by measuring sensitivity of NPC cells to theTP-targeting drug, 5-fluoro-5 ¶-deoxyuridine (5 ¶-DFUR).Results: There was a high correlation between cytoplasmic hnRNP K and high TP (P < 0.001).Both cytoplasmic hnRNP K and high TP were associated with poor overall survival (OS; P = 0.007 and P < 0.001, respectively) and distant metastasis-free survival (P = 0.003 and 0.001, respectively) of NPC patients. A multivariate analysis confirmed that both cytoplasmic hnRNP K and high TP are independent prognostic predictors for OS (P = 0.020 and 0.010, respectively). NPC cells expressing highTP were more sensitive to treatment with theTP-targeting drug, 5 ¶-DFUR. Conclusions: Cytoplasmic hnRNP K and high TP are associated with shorter OS and distant metastasis-free survival in NPC patients. In vitro experiments suggest that NPC tumors with high TP expression may be sensitive to 5 ¶-DFUR treatment. Cytoplasmic hnRNP K and high TP may be potential prognostic and therapeutic markers for NPC, but additional validation studies are warranted.

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“…17) Serum concentrations of some types of growth factors are useful to predict treatment response and patients' outcome in esophageal squamous cell carcinoma (SCC). 18,19) These serum markers may complement the clinical impact of TNM staging. The purpose of this study was therefore to determine both the clinicopathological and prognostic significance of S-MK in these patients.…”

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confidence: 99%

Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma

et al. 2003

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High preoperative serum midkine concentration is associated with poor survival in patients with esophageal cancer, even after radical surgery, and thus may have prognostic value. Midkine (MK), a heparin-binding growth factor, is expressed in numerous cancer tissues, and serum MK (S-MK) concentrations are increased in patients with various neoplasms. The aim of this study is to evaluate the clinical significance of S-MK in patients with esophageal squamous cell cancer (SCC). S-MK was measured by enzyme-linked immunosorbent assay in 135 healthy controls, 16 patients with benign esophageal disease, and 93 patients with primary esophageal SCC before surgery. The serum concentrations of carcinoembryonic antigen (CEA), SCC antigen (SCC-Ag), and cytokeratin 19 fragment (CYFRA21-1) were also evaluated. All patients with esophageal SCC underwent radical esophagectomy. Tumor MK expression was assessed by immunohistochemistry in 14 fresh tumor specimens. To determine whether S-MK is of value as a prognostic factor, the authors conducted a survival analysis using Cox's proportional hazards model. S-MK values in patients with esophageal SCC were significantly higher than those in healthy controls (417 ± ± ± ±342 pg/ml vs. 154 ± ± ± ±76 pg/ml, P < < < <0.001). Using 300 pg/ml as the cut-off value (representing the mean + + + +2 standard deviations of the S-MK of healthy controls), 61% of patients with esophageal SCC were classified as positive. MK expression by the tumor was significantly associated with high level of S-MK. High S-MK ( ≥ ≥ ≥ ≥300 pg/ml) was associated with tumor size, immunoreactivity and poor survival. Multivariate analysis indicated that S-MK was an independent prognostic factor. S-MK may be a useful tumor marker for esophageal SCC. Increased preoperative S-MK in patients with esophageal SCC is associated with poor survival. (Cancer Sci 2003; 94: 628-632)

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Prognostic significance of serum thymidine phosphorylase concentration in esophageal squamous cell carcinoma

Cited by 42 publications

References 55 publications

Thrombocytosis and Raised CRP Levels Predicts Advanced Stage in Esophageal Carcinoma

Thrombocytosis and Raised CRP Levels Predicts Advanced Stage in Esophageal Carcinoma

Heterogeneous Ribonucleoprotein K and Thymidine Phosphorylase Are Independent Prognostic and Therapeutic Markers for Nasopharyngeal Carcinoma

Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma

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