Prognostic significance of systemic immune-inflammation index in patients with bladder cancer: A systematic review and meta-analysis

Cao, Wei; Shao, Yifeng; Zou, Shangzhang; Wang, Na; Wang, Jinguo

doi:10.1097/md.0000000000030380

Cited by 9 publications

(7 citation statements)

References 33 publications

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“…In the metaanalysis involving eight studies carried out by Zhou et al, the higher SII remarkably predicted poor OS and extensive-stage among patients with small cell lung cancer (SCLC) (30). As shown by Cao et al in a meta-analysis of 11 studies, an increased SII before treatment remarkably predicted dismal OS, CSS, PFS, and recurrence-free survival (RFS) inpatients with bladder cancer (50).…”

Section: Discussionmentioning

confidence: 96%

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Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis

Mao

Yang

2023

Front. Oncol.

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BackgroundThe prognosis of several malignancies has been influenced by the systemic immune-inflammation index (SII); however, its association with the prognostic outcome of ovarian cancer (OC) remains controversial. The present meta-analysis focused on the systemic and comprehensive identification of the role of SII in predicting OC prognosis.MethodsWe searched the Web of Science, PubMed, Cochrane Library, Embase, and China National Knowledge Infrastructure (CNKI) from inception until March 6, 2023. To predict the prognostic value of SII for overall survival (OS) and progression-free survival (PFS) in patients with OC, we calculated pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs).ResultsThe meta-analysis included six studies involving 1546 patients. The combined results showed that a high SII was significantly associated with poor OS (HR=2.70, 95% CI=1.98–3.67, p<0.001) and poor PFS (HR=2.71, 95% CI=1.78–4.12, p<0.001) in OC patients. These results were confirmed using subgroup and sensitivity analyses.ConclusionOur results concluded that a high SII significantly predicted poor OS and PFS in patients with OC. Therefore, it can be speculated that the SII may have an independent effect on the prognosis of OC.

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Section: Discussionmentioning

confidence: 96%

“…As shown by Cao et al. in a meta-analysis of 11 studies, an increased SII before treatment remarkably predicted dismal OS, CSS, PFS, and recurrence-free survival (RFS) inpatients with bladder cancer ( 50 ).…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis

Mao

Yang

2023

Front. Oncol.

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“…20 In the study by Cao et al meta-analysis revealed that high pretreatment SII levels in bladder cancer patients were significantly associated with worse overall survival, cancer-specific survival, and relapse-free survival. 21 In a study with Bechet’s patients, the SII value was shown to be worse. It was higher in active Bechet’s patients and the cut-off value was >552.12 × 10 3 /mm 3 when deciding on treatment.…”

Section: Discussionmentioning

confidence: 99%

The effect of systemic inflammatory index and systemic inflammatory response index on success of varicoselectomy

Erdogan,

2023

Urologia

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Background: Varicocele is the most common correctable cause of male infertility. The treatment of varicocele is surgery. However, which patients will benefit from the surgery is controversial. Our aims to investigate the effect of systemic immune-inflammation index (SII) and systemic inflammatory response index (SIRI) on varicocelectomy success. Methods: Patients who underwent varicocelectomy in our clinic between January 2016 and June 2022 were analyzed retrospectively. Varicocelectomy success was defined as >50% increase in post-operative total motile sperm count (TMSC) in those with pre- operative TMSC > 5 million and at least 100% increase in those with <5 million. The patients were divided into two groups as benefiting from the treatment (Group 1) and no benefits (Group 2). Results: Of the 207 patients who underwent varicocelectomy, 144 (69.6%) of them improved their semen parameters, and 63 (30.4%) did not. The optimum cut-off value of SII was 334.6, with an AUC of 0.733 (95% CI: 0.665–0.813). The best cut-off value for SIRI of 0.882, with an AUC of 0.692 (95% CI: 0.607–0.772). The highest sensitivity and specificity were 0.692 and 0.601 ( p < 0.001). In the multivariate analysis, only SII (OR: 3.152, 95% CI: 1.316–7.358; p = 0.003) and SIRI (OR: 2.919, 95% CI: 1.472–5.774; p = 0.002) were independent predictive factors for varicocelectomy success. Conclusions: Our results showed that preoperative SII and SIRI values were lower in infertile patients who underwent successful varicocelectomy. Therefore, we think that these parameters will be useful in identifying patients who will benefit before varicocelectomy.

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“…SII can be easily obtained preoperatively. It has been reported to be predictive of OS and disease-free survival in different types of cancer [ 33 , 34 ]. There is at least one study in advanced pancreatic cancer, but several others with resection of other cancers [ 35 - 37 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostication for recurrence patterns after curative resection for pancreatic ductal adenocarcinoma

Ang,

Michaelides,

Chelala

et al. 2024

Ann Hepatobiliary Pancreat Surg

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Backgrounds/Aims This study aimed to investigate patterns and factors affecting recurrence after curative resection for pancreatic ductal adenocarcinoma (PDAC). Methods Consecutive patients who underwent curative resection for PDAC (2011-21) and consented to data and tissue collection (Barts Pancreas Tissue Bank) were followed up until May 2023. Clinico-pathological variables were analysed using Cox proportional hazards model. Results Of 91 people (42 males [46%]; median age, 71 years [range, 43–86 years]) with a median follow-up of 51 months (95% confidence intervals [CIs], 40–61 months), the recurrence rate was 72.5% (n = 66; 12 loco-regional alone, 11 liver alone, 5 lung alone, 3 peritoneal alone, 29 simultaneous loco-regional and distant metastases, and 6 multi-focal distant metastases at first recurrence diagnosis). The median time to recurrence was 8.5 months (95% CI, 6.6–10.5 months). Median survival after recurrence was 5.8 months (95% CI, 4.2–7.3 months). Stratification by recurrence location revealed significant differences in time to recurrence between loco-regional only recurrence (median, 13.6 months; 95% CI, 11.7–15.5 months) and simultaneous loco-regional with distant recurrence (median, 7.5 months; 95% CI, 4.6–10.4 months; p = 0.02, pairwise log-rank test). Significant predictors for recurrence were systemic inflammation index (SII) ≥ 500 (hazard ratio [HR], 4.5; 95% CI, 1.4–14.3), lymph node ratio ≥ 0.33 (HR, 2.8; 95% CI, 1.4–5.8), and adjuvant chemotherapy (HR, 0.4; 95% CI, 0.2–0.7). Conclusions Timing to loco-regional only recurrence was significantly longer than simultaneous loco-regional with distant recurrence. Significant predictors for recurrence were SII, lymph node ration, and adjuvant chemotherapy.

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Prognostic significance of systemic immune-inflammation index in patients with bladder cancer: A systematic review and meta-analysis

Cited by 9 publications

References 33 publications

Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis

Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis

The effect of systemic inflammatory index and systemic inflammatory response index on success of varicoselectomy

Prognostication for recurrence patterns after curative resection for pancreatic ductal adenocarcinoma

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