Prognostic significance of tenascin-C expression in superficial and invasive bladder cancer

Abstract

Aims:Tenascin-C (Tn-C) is an extracellular matrix glycoprotein that is upregulated in malignant tumours. Tn-C promotes cell growth, cell migration, and angiogenesis. It has been suggested to be a prognostic factor in various types of malignant tumours, but there is little information on its significance in bladder cancer with regard to overall survival (OS) and recurrence free survival (RFS).Methods:Tn-C expression was studied in 106 patients with bladder cancer diagnosed between 1994 and 1997. Immunohistochemistry was performed using a monoclonal antibody against Tn-C. RFS and OS were estimated by the Kaplan–Meier method and compared by the log rank test in univariate analysis and by the Cox multistep regression method in multivariate analysis.Results:Within the mean follow up period of 126 months, patients with diffuse Tn-C staining in the tumour stroma had a significantly worse OS than those with negative staining or only moderate Tn-C expression (p = 0.025). Patients with cytoplasmic expression of Tn-C had a significantly better OS than those without (p = 0.001). Multivariate analysis, taking into consideration age, grade, stage, tumour associated carcinoma in situ, progression, and Tn-C staining in tumour stroma, showed that only expression of Tn-C in invasive tumour cells was an independent positive prognostic factor for OS (p = 0.049).Conclusions:Tn-C may provide important prognostic information in bladder cancer depending on the expression pattern in the tumour stroma or cytoplasm of the tumour cells.

Potencjalne zastosowanie tenascyny C w diagnozowaniu i leczeniu nowotworów

“…Z badań [71] poświęconych ocenie znaczenia tenascyny C w raku pęcherza moczowego wynika, że lokalizacja i wzór ekspresji TN-C w komórkach nowotworowych mają znaczenie prognostyczne i potencjalnie mogą zostać wykorzystane do wykrywania nowotworów o tym umiejscowieniu.…”

Tenascin-C Expression and Its Prognostic Significance in Colorectal Cancer

“…In many cancer forms, such as breast [14, 15], lung [16], brain [17], urological [18, 19], malignant melanoma [20], pheochromocytoma [21], cholangiocarcinoma [22] and adipocytic tumors [23], a high tenascin-C expression has been correlated with a poor patient survival [5, 6]. While this correlation applies to some cancers, there are also reports where tenascin-C expression correlates with a lower stage of disease and a better patient outcome [5, 6, 24, 25].…”

The Role of the Tumor Microenvironment in Regulating Angiogenesis

“…CAFs in the stroma of invasive carcinoma continue depositing large amounts of ECM, including tenascin C in some cases (Chiquet-Ehrismann et al 1986;Inaguma et al 1988). It has been shown that in breast and bladder carcinomas expression of tenascin C correlates with increased tumor invasiveness (Mackie et al 1987;Brunner et al 2004). The accumulation of ECM in tumors contributes to increased interstitial fluid pressure which hinders oxygen and nutrient diffusion (Netti et al 2000;Brown et al 2004).…”