Prognostic significance of the expression of metastasis-associated in colon cancer-1 in gynecologic cancers and breast cancer

Wang, Lijun; Fan, Liying; Xu, Hongxing; Jiang, Haiyuan

doi:10.1097/md.0000000000024255

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…in cell culture, as well as carcinogenesis and metastases in several mouse models ( 13 , 15 , 16 ). Since the discovery of MACC1, the authors of the present study, as well as several other research groups have demonstrated the clinical significance of MACC1 as a causal, prognostic and predictive biomarker for >20 solid cancer types ( 14 ), including meta-analyses for solid cancers, cancers of the digestive system, colorectal, hepatocellular, gastric, gynecological and breast cancer ( 17 - 22 ). The causal contribution of MACC1 for rewiring cell metabolism has been demonstrated by the authors of the present study, as well as others ( 23 - 25 ).…”

Section: Introductionmentioning

confidence: 79%

Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association

et al. 2022

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Obesity is a major and increasing public health concern, associated with an increased risk of and mortality from several types of cancer including colorectal cancer (CRC), being associated with cancer progression, metastasis and resistance to therapy. It was hypothesized that the expression of cancer/metastasis-inducing gene metastasis-associated in colon cancer 1 (MACC1) is increased in obesity, which may constitute a link to obesity-induced cancer. The present study thus analyzed circulating cell-free plasma MACC1 expression levels in human obese (vs. normal weight) adult individuals from independent studies, namely the Martin Luther University (MLU) study (n=32) and the Metabolic syndrome study (MetScan, Berlin) (n=191). Higher plasma MACC1 levels were found in obese individuals, increasing with a greater body fat mass and body mass index; these levels were predominantly observed in male and to a lesser extent in female individuals, although the results were not significant. A reduction in body fat mass following dietary intervention and physical exercise decreased the MACC1 expression levels in the MLU study. Furthermore, Wistar rats with diet-induced obesity exhibited slightly increased plasma MACC1 levels compared with rats of normal weight. The obese Wistar rats exposed to azoxymethane to induce colon cancer exhibited a more severe colon tumor outcome, which was associated with significantly increased MACC1 levels compared with their non-obese littermates. On the whole, the findings of the present study suggest an association between MACC1 and obesity, as well as with obesity-induced CRC.

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Section: Introductionmentioning

confidence: 79%

Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association

et al. 2022

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“…Despite the fact that several studies have discussed the prognostic value of MACC1 expression in BCs ( Table 1 ), no firm conclusions have been reached because of the contradictory findings caused by the small sample sizes of earlier studies. To ascertain the predictive significance of MACC1 expression in gynecologic and BC, Wang et al [ 68 ] conducted a meta-analysis of 1811 patients included in a comprehensive search of databases such as PubMed, Web of Science, and Embase to determine the prognostic value of MACC1 expression in BC. High expression of MACC1 in BCs predicts shorter OS and RFS, poorer tumor differentiation, more advanced FIGO staging, and earlier lymph node metastasis.…”

Section: Effect Of Macc1 Overexpression On Bcmentioning

confidence: 99%

MACC1 as a Potential Target for the Treatment and Prevention of Breast Cancer

Jiao

Yang

et al. 2023

Biology

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Metastasis associated in colon cancer 1 (MACC1) is an oncogene first identified in colon cancer. MACC1 has been identified in more than 20 different types of solid cancers. It is a key prognostic biomarker in clinical practice and is involved in recurrence, metastasis, and survival in many types of human cancers. MACC1 is significantly associated with the primary tumor, lymph node metastasis, distant metastasis classification, and clinical staging in patients with breast cancer (BC), and MACC1 overexpression is associated with reduced recurrence-free survival (RFS) and worse overall survival (OS) in patients. In addition, MACC1 is involved in BC progression in multiple ways. MACC1 promotes the immune escape of BC cells by affecting the infiltration of immune cells in the tumor microenvironment. Since the FGD5AS1/miR-497/MACC1 axis inhibits the apoptotic pathway in radiation-resistant BC tissues and cell lines, the MACC1 gene may play an important role in BC resistance to radiation. Since MACC1 is involved in numerous biological processes inside and outside BC cells, it is a key player in the tumor microenvironment. Focusing on MACC1, this article briefly discusses its biological effects, emphasizes its molecular mechanisms and pathways of action, and describes its use in the treatment and prevention of breast cancer.

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“…MACC1 has been established by us and many other groups as crucial for tumor development and metastasis. Thus, it has been found to be a prognostic and predictive biomarker for tumor progression and metastasis formation in a multitude of solid cancer types, including supportive meta-analyses for solid cancers; hepatocellular and gastrointestinal tract cancers, such as CRC and gastric cancer; and gynecological and breast cancer [ 7 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

MACC1-Induced Collective Migration Is Promoted by Proliferation Rather Than Single Cell Biomechanics

Hohmann

Grabiec

Dahlmann

et al. 2022

Cancers

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Metastasis-associated in colon cancer 1 (MACC1) is a marker for metastasis, tumor cell migration, and increased proliferation in colorectal cancer (CRC). Tumors with high MACC1 expression show a worse prognosis and higher invasion into neighboring structures. Yet, many facets of the pro-migratory effects are not fully understood. Atomic force microscopy and single cell live imaging were used to quantify biomechanical and migratory properties in low- and high-MACC1-expressing CRC cells. Furthermore, collective migration and expansion of small, cohesive cell colonies were analyzed using live cell imaging and particle image velocimetry. Lastly, the impact of proliferation on collective migration was determined by inhibition of proliferation using mitomycin. MACC1 did not affect elasticity, cortex tension, and single cell migration of CRC cells but promoted collective migration and colony expansion in vitro. Measurements of the local velocities in the dense cell layers revealed proliferation events as regions of high local speeds. Inhibition of proliferation via mitomycin abrogated the MACC1-associated effects on the collective migration speeds. A simple simulation revealed that the expansion of cell clusters without proliferation appeared to be determined mostly by single cell properties. MACC1 overexpression does not influence single cell biomechanics and migration but only collective migration in a proliferation-dependent manner. Thus, targeting proliferation in high-MACC1-expressing tumors may offer additional effects on cell migration.

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Prognostic significance of the expression of metastasis-associated in colon cancer-1 in gynecologic cancers and breast cancer

Cited by 6 publications

References 24 publications

Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association

Obesity, colorectal cancer and MACC1 expression: A possible novel molecular association

MACC1 as a Potential Target for the Treatment and Prevention of Breast Cancer

MACC1-Induced Collective Migration Is Promoted by Proliferation Rather Than Single Cell Biomechanics

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