Prognostic significance of the number of lymph nodes examined in patients with lymph node‐negative breast carcinoma

Moorman, Patricia G.; Hamza, Ali; Marks, Jeffrey R.; Olson, John A.

doi:10.1002/1097-0142(20010615)91:12<2258::aid-cncr1256>3.3.co;2-m

Cited by 3 publications

(4 citation statements)

References 3 publications

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“…The effect of the number of lymph nodes examined on disease control in patients with lymph node‐negative breast carcinoma has been demonstrated by some,9–4 but not all, retrospective studies 15–17. To our knowledge, the therapeutic impact of axillary lymph node treatment on survival remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, one study described worse outcomes with the removal of more lymph nodes 15. Furthermore, other studies suggested that the extent of ALD is not a significant prognostic factor 16, 17. To address this controversy, we analyzed the impact of the number of axillary lymph nodes recovered on disease‐free survival (DFS) in patients who underwent mastectomy and in patients who underwent breast‐conservation therapy (BCT).…”

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confidence: 99%

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Patterning the heart, a template for human cardiomyocyte development

Lopes

Hassink

Feijen

et al. 2006

Developmental Dynamics

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Although in mice, the dynamics of gene expression during heart development is well characterized, information on humans is scarce due to the limited availability of material. Here, we analyzed the transcriptional distribution of Mlc-2a, Mlc-1v, Mlc-2v, and atrial natriuretic factor (ANF) in human embryonic hearts between 7 and 18 weeks of gestation and in healthy and hypertrophic adult hearts by in situ hybridization and compared expression with that in mice. Strikingly, Mlc-2a, Mlc-1v, and ANF, which are essentially chamber-restricted in mice by mid-gestation, showed a broader distribution in humans. On the other hand, Mlc-2v may prove to be an adequate ventricular marker in humans in contrast to mouse. This study emphasizes the importance of careful comparative human-animal analyses during embryonic development and adulthood, as avoiding erroneous extrapolations may be critical to develop new and successful myocardial replacement therapies.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Patterning the heart, a template for human cardiomyocyte development

Lopes

Hassink

Feijen

et al. 2006

Developmental Dynamics

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“…The presence of axillary lymph node (LN) metastases is one of the most powerful predictor of survival in primary breast carcinoma (1). Nevertheless, for pN0 patients, the prognostic significance of the total number of analyzed LN remains controversial (2–6). The objective of the present study was to determine the impact of the number of negative LN on outcomes for patients with pT1‐2 N0 M0 breast carcinoma.…”

Section: Characteristics Of the Patients Bygroupsmentioning

confidence: 99%

Prognostic Significance of the Number of Negative Axillary Lymph Nodes in Patients with pT1-2 N0 M0 Breast Cancer: A Population-Based Study

et al. 2010

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“…However, another group studied the relationship between the number of detected lymph nodes examined and breast carcinoma survival among 911 women with lymph node‐negative breast carcinoma, with a median length of follow up being after 84 months. They found that the number of lymph nodes examined is unlikely to be an important prognostic indicator in patients with lymph node‐negative breast carcinoma 34 . Larger patient populations receiving the same treatment methods should be studied to elucidate the prognostic value of lymph nodes examined for lymph node‐negative breast carcinoma.…”

Section: Conventional Markersmentioning

confidence: 99%

Predictive and prognostic markers for invasive breast cancer

Mori

Yang

Kakudo

2002

Pathology International

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Breast cancer is one of the most serious carcinomas among women worldwide, yet there are now encouraging signs that improvements in the mortality rate may be possible. The use of hormone therapy and chemotherapy has been widely accepted as treatment for breast cancer. Predictive factors can be used to predict response or lack of response to a particular therapy, and prognostic factors can be useful in making decisions about which patients should receive adjuvant therapy. Histopathology remains the universal basis of diagnosis, with the identification of new surrogate markers for potential new treatments. These are aimed at blocking tumor cell proliferation, neutralizing growth factors, stimulating apoptosis and blocking metastasis, and represent an integral part of new approaches for improving clinical management of patients with breast cancer. We review the standard predictive and prognostic factors that are routinely available today, and also describe some of the new, potential markers that are currently under investigation.

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Prognostic significance of the number of lymph nodes examined in patients with lymph node‐negative breast carcinoma

Cited by 3 publications

References 3 publications

Patterning the heart, a template for human cardiomyocyte development

Patterning the heart, a template for human cardiomyocyte development

Prognostic Significance of the Number of Negative Axillary Lymph Nodes in Patients with pT1-2 N0 M0 Breast Cancer: A Population-Based Study

Predictive and prognostic markers for invasive breast cancer

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