Prognostic significance of the revised French-American-British classification for acute lymphocytic leukaemia

Abstract

Summary. The French‐American‐British (FAB) classification of acute lymphocytic leukaemia (ALL) has recently been modified to improve its reproducibility. We therefore thought it beneficial to test the utility of this modified classification in the prognosis of children with ALL. Eighty‐eight patients of less than 18 years of age with ALL were subtyped according to the modified FAB classification by two independent observers. The initial concordance was 86%. Seventy per cent of the patients were subtyped as LI, 27% as L2 and 3% as L3. Patients with L3 subtype were not analysed further. No significant differences were observed between Ll and L2 subtypes when the distribution of other prognostic factors were examined. No differences were observed between L1 and L2 subtypes in the achievement of complete remission. Patients with L1 morphology demonstrated no significant increased duration of first remission or survival when compared to patients with L2 morphology. We conclude that the morphology oflymphoblasts may not be an independent prognostic variable in patients with ALL.

Association of Janus kinase 2 (JAK2) polymorphisms with acute leukemia susceptibility

“…These cases were diagnosed at seven large hospitals in Jiangsu Province from August 2006 to October 2008. The diagnosis of acute leukemia was made according to the World Health Organization (WHO) and French‐American‐British (FAB) criteria (Davey et al. , 1983; Bloomfield & Brunning, 1985; Jaffe et al.…”

“…These cases were diagnosed at seven large hospitals in Jiangsu Province from August 2006 to October 2008. The diagnosis of acute leukemia was made according to the World Health Organization (WHO) and French-American-British (FAB) criteria (Davey et al, 1983;Bloomfield & Brunning, 1985;Jaffe et al, 2001). Patients with acute leukemia who were diagnosed with any other cancer types or other hematological malignancies were eliminated from the study and suitably replaced to attain the target number of subjects.…”

Signal transducer and activator of transcription 3 (STAT3) gene polymorphisms are associated with treatment outcomes in acute myeloid leukemia

“…A total of 130 patients with AML diagnosed at seven large hospitals in Jiangsu Province between August 2006 and September 2008 were enrolled in the study. The diagnosis was according to the World Health Organization and French‐American‐British (FAB) criteria (Davey et al. , 1983; Bloomfield & Brunning, 1985; Jaffe et al.…”

“…A total of 130 patients with AML diagnosed at seven large hospitals in Jiangsu Province between August 2006 and September 2008 were enrolled in the study. The diagnosis was according to the World Health Organization and French-American-British (FAB) criteria (Davey et al, 1983;Bloomfield & Brunning, 1985;Jaffe et al, 2001). All patients signed the written informed consent for genetic analysis according to the Declaration of Helsinki and were aware of the existence of other treatment options according to the Ethics Committee of Southeast University, in accordance with the Chinese guidelines for blood donation.…”

Treatment of acute lymphoblastic leukemia in children: a review of literature

“…Совершенствование программ терапии с учетом иммунобиологических особенностей ОЛЛ позволило нивелировать неблагоприятное прогностическое влияние таких факторов, как тип бластов по FAB-классификации и Т-клеточный иммунофенотип ОЛЛ [18,19].…”