Prognostic significance of the stress hyperglycemia ratio and admission blood glucose in diabetic and nondiabetic patients with spontaneous intracerebral hemorrhage

Liang, Shengru; Tian, Xiaoxi; Gao, Fei; Man, Minghao; Wang, Qi; Li, Jianwei; Li, Lihong; Yang, Yang

doi:10.1186/s13098-024-01293-0

Cited by 4 publications

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

A systematic review and meta-analysis of the effect of hyperglycemia on admission for acute myocardial infarction in diabetic and non-diabetic patients

Alawaji,

Musslem,

Alshalahi

et al. 2024

Diabetol Metab Syndr

View full text Add to dashboard Cite

Introduction Regarding a potential relationship between diabetes and the prognostic significance of hyperglycemia in patients presenting with acute myocardial infarction (AMI), there is still debate. Therefore, we aimed in this study to demonstrate the effect of hyperglycemia on different outcomes in AMI patients, whether they are diabetic or not. Methods We searched PubMed, Web of Science, and Scopus using the following search strategy: “Diabetes” or “Diabetic” AND “Acute myocardial infarction” OR “AMI” AND “hyperglycemia” OR “glucose level” to find eligible articles that needed to go through the screening process for inclusion in our study. We conducted a meta-analysis of 19 included studies from Japan, Germany, China, the United Kingdom, and others using Review Manager version 5.4 software, pooling the mean difference in continuous variables, the number and total of dichotomous variables to measure the odds ratio (OR), and the generic inverse variance of OR or hazard ratio (HR) as reported in the included studies. Results The mean age of the participants ranged from 56.3 to 72.3 years old. The difference in blood glucose levels between diabetes and non-diabetes patients was found to be statistically significant, with an SMD of 1.39 (95%CI: 1.12, 1.66, p < 0.00001). In diabetic patients, hyperglycemia was statistically significantly associated with mortality, with a HR of 1.92 (95% CI: 1.45, 2.55, p < 0.00001) and an OR of 1.76 (95% CI: 1.15, 2.7, p = 0.01). In non-diabetic patients admitted with AMI, hyperglycemia was statistically significantly associated with mortality, with a HR of 1.56 (95% CI: 1.31, 1.86, p < 0.00001) and an OR of 2.89 (95% CI: 2.47, 3.39, p < 0.00001). AMI patients who were diabetic were statistically more likely to have a major adverse cardiovascular event (MACE) (HR = 1.9; 95% CI: 1.19–3.03; p = 0.007). AMI patients who were not diabetic were also statistically more likely to have a MACE (HR = 1.6; 95% CI: 1.15–2.23, p = 0.006). Conclusion Hyperglycemia in AMI patients is a predictor of worse outcomes, including MACE and mortality, regardless of whether these patients are diabetic or not. In these patients, some factors act as predictors of mortality, including older age, higher glucose levels on admission, and a high Killip class.

show abstract

A systematic review and meta-analysis of the effect of hyperglycemia on admission for acute myocardial infarction in diabetic and non-diabetic patients

Alawaji,

Musslem,

Alshalahi

et al. 2024

Diabetol Metab Syndr

View full text Add to dashboard Cite

show abstract

The prognostic impact of stress hyperglycemia ratio on mortality in cardiogenic shock: a MIMIC-IV database analysis

Xie,

Chen,

et al. 2024

Diabetol Metab Syndr

View full text Add to dashboard Cite

Background The stress hyperglycemia ratio (SHR) has been established as a predictor of unfavorable outcomes across various diseases. However, its relationship with prognosis in patients with cardiogenic shock (CS) remains unclear. This study aims to investigate the association between SHR and outcomes in CS patients. Methods A total of 904 CS patients with their first ICU admission were included in this study, utilizing data from the American Medical Information Mart for Intensive Care (MIMIC-IV) database. The primary endpoints were all-cause mortality at 30 days and 360 days. Patients were stratified into three groups based on the tertiles of the SHR. Results The mean age of the cohort was 67.62 years, with 67.3% of participants being men. During the follow-up period, 221 patients (24.4%) died within 30 days, and 360 patients (39.8%) died within 360 days. The 30-day all-cause mortality rates were 16.9%, 22.3%, and 34.2% in the T1, T2, and T3 groups, respectively ( p < 0.001), while the 360-day all-cause mortality rates were 34.9%, 39.0%, and 45.6%, respectively ( p = 0.015). Compared with patients in T1, those in T3 exhibited a significantly higher risk of 30-day all-cause mortality (HR = 2.140, 95% CI: 1.522–3.008, p < 0.001) and 360-day all-cause mortality (HR = 1.495, 95% CI: 1.157–1.931, p = 0.002). Restricted cubic spline (RCS) analyses demonstrated an approximately linear relationship between SHR and 360-day all-cause mortality (p for overall = 0.011; p for nonlinearity = 0.099). However, a nonlinear association was observed between SHR and 30-day all-cause mortality (p for overall < 0.001; p for nonlinearity = 0.030), with the risk increasing significantly when SHR exceeded 1.176. Subgroup analyses revealed that the effect of SHR was consistent across most subgroups except in patients with and without acute myocardial infarction (AMI). In patients with AMI, SHR was associated with a significantly elevated risk of mortality, whereas no significant association was observed in patients without AMI. For 30-day all-cause mortality, the HR was 1.059 (95% CI: 1.040–1.078) in patients with AMI and 1.002 (95% CI: 0.966–1.040) in those without AMI (p for interaction = 0.007). For 360-day all-cause mortality, the HR was 1.043 (95% CI: 1.026–1.061) in patients with AMI and 0.984 (95% CI: 0.955–1.014) in those without AMI (p for interaction < 0.001). Conclusion Elevated SHR was significantly associated with increased 30-day and 360-day all-cause mortality in patients with CS, particularly in those with CS complicated by AMI. SHR may serve as a valuable marker for risk stratification and guiding subsequent interventions in CS patients. However, further prospective studies are needed to confirm these findings.

show abstract

Stress hyperglycemia ratio is a risk factor for mortality in trauma and surgical intensive care patients: a retrospective cohort study from the MIMIC-IV

Zhang,

Yan,

Sun

et al. 2024

Eur J Med Res

View full text Add to dashboard Cite

Background Stress hyperglycemia ratio (SHR) can reduce the impact of baseline glucose on the stress hyperglycemia level. Studies have shown that SHR is associated with adverse outcomes. However, its relationship with the prognosis of trauma/surgical ICU patients has not been fully studied. The objective of this study was to explore the relationship between SHR and the short-term and long-term mortality in trauma/surgical ICU patients. Methods Clinical data of trauma/surgical ICU patients were extracted from MIMIC-IV. The primary outcome was 28-day all-cause mortality, and the secondary outcome was 365-day all-cause mortality. Boruta algorithm was used to screen the important features related to the 28-day mortality, and Kaplan–Meier curve, Cox proportional hazards regression, and restricted cubic spline were used to explore the relationship between SHR and clinical outcomes. Results A total of 1744 patients were included, of whom 786 were male and 958 were female. The 28-day and 365-day mortality rates were 14.7% and 27.2%, respectively. Multivariate Cox proportional hazards analysis showed that an increase in SHR was significantly associated with an increased risk of 28-day mortality [HR (95% CI) 1.30 (1.07, 1.58), p = 0.009] and 365-day mortality [HR (95% CI) 1.05 (1.02–1.09), p = 0.005]. Restricted cubic spline curve showed that the relationship between SHR and survival rate was "U-shaped". Conclusions Increase in SHR is associated with an increased risk of 28-day and 365-day all-cause mortality in trauma/surgical ICU patients.

show abstract

Prognostic significance of the stress hyperglycemia ratio and admission blood glucose in diabetic and nondiabetic patients with spontaneous intracerebral hemorrhage

Cited by 4 publications

References 45 publications

A systematic review and meta-analysis of the effect of hyperglycemia on admission for acute myocardial infarction in diabetic and non-diabetic patients

A systematic review and meta-analysis of the effect of hyperglycemia on admission for acute myocardial infarction in diabetic and non-diabetic patients

The prognostic impact of stress hyperglycemia ratio on mortality in cardiogenic shock: a MIMIC-IV database analysis

Stress hyperglycemia ratio is a risk factor for mortality in trauma and surgical intensive care patients: a retrospective cohort study from the MIMIC-IV

Contact Info

Product

Resources

About