Prognostic significance of the systemic immune inflammation index in patients with metastatic and unresectable pancreatic cancer

Han, Rongshuang; Tian, Zibin; Jiang, Yueping; Guan, Ge; Wang, Xiaowei; Sun, Xue‐Guo; Yu, Yanan; Jing, Xue

doi:10.3389/fsurg.2022.915599

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…Patients with a high level of the inflammatory markers SII, neutrophil-to-lymphocyte count neutrophil/lymphocyte ratio (NLR), and the platelet-to-lymphocyte count, may be more prone to early liver metastasis. [16] Of note, findings of the present study conform with these previous information on the impact of SII with the severity of inflammation in the pancreatic tissue.…”

Section: Discussionsupporting

confidence: 92%

Investigation of the prognostic role of systemic immunoinflammatory index in patients with acute pancreatitis

Hokenek

Kılıç

Alışkan

2023

Ulus Travma Acil Cerrahi Derg

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BACKGROUND:The aim of this study was to examine the effect of systemic immunoinflammatory index (SII), calculated on presentation to the emergency department (ED), on the prediction of clinical outcomes of patients who were diagnosed with acute pancreatitis (AP). METHODS:This research was designed as a single-center, cross-sectional, and retrospective study. Adult patients who were diagnosed with AP in the ED between October 2021 and October 2022 in the tertiary care hospital, whose diagnostic and therapeutic procedures were complete in the data recording system, have been included in the study. RESULTS:Mean age, respiratory rate, and length of stay of the non-survivors were significantly higher than the mean of the survivors (t-test, p=0.042, p=0.001, and p=0.001, respectively). Mean SII score of the patients with fatal outcome was higher than the survivors (t-test, p=0.001). ROC analysis of the SII score to predict mortality revealed that the area under the curve was found to be 0.842 (95%CI 0.772-0.898), and the Youden index was 0.614, (p=0.001). When the cutoff value of the SII score in determining mortality is >1243, the sensitivity of the score was found to be 85.0%, specificity 76.4%, positive predictive value 37.0%, and negative predictive value 96.9%. CONCLUSION: SII score was statistically significant in estimating mortality. SII calculated on presentation to the ED can be a useful scoring system to predict the clinical outcomes of patients who were admitted to the ED and were diagnosed with AP.

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Section: Discussionsupporting

confidence: 92%

Investigation of the prognostic role of systemic immunoinflammatory index in patients with acute pancreatitis

Hokenek

Kılıç

Alışkan

2023

Ulus Travma Acil Cerrahi Derg

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“…In patients with metastatic or unresectable colon cancer, the higher the SII index, the shorter the survival period. And a high SII index may predict that liver metastases from colon cancer can occur at an early stage [ 20 ]. A meta-analysis included 3565 patients with esophageal cancer patients receiving operation in nine studies indicated that higher SII was associated with a shorter length of survival [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study

Shi

Zhang

et al. 2023

BMC Public Health

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Background Chronic inflammatory responses have been reported to be associated with low muscle mass and systemic immune-inflammation index(SII) is a novel indicator of inflammation. The purpose of our study was to clarify the relationship between SII and low muscle mass. Methods This study was a cross-sectional study based on National Health and Nutrition Examination Survey (2011–2018). SII was calculated as the platelet count × neutrophil count/lymphocyte count. Appendicular skeletal muscle index was used to define low muscle mass. The individuals were divided into four groups by the quartile of SII (Q1-Q4). Multivariate weighted logistic regression analysis, smooth curve fitting and subgroup analysis were used to investigate the relationship between SII and sarcopenia. Subgroup analysis were based on demographic and clinical variables. Results There were 10,367 individuals enrolled in our final analysis. The overall mean age was 39.39 years and 49.17% were males. The overall prevalence of low muscle mass in the study population was 8.77%. The smooth curve fitting analysis indicated a near-linear relationship between SII and low muscle mass. In multivariate weighted logistic regression analysis, the odds ratio (OR) of Q4 is 1.28 (95% CI, 1.16–1.40) for low muscle mass when compared to lowest quartile of the SII. In subgroup analysis, SII still increased the risk of low muscle mass independently. Conclusion The increased SII levels were associated with an increased risk of low muscle mass in a large population. Our study increased the understanding between inflammation and low muscle mass. Anti-inflammation therapy may be important for low muscle mass.

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“…Patient age, clinical performance, nutrition, and hematological status play significant roles in determining their outcomes [3,4]. Systemic inflammation associated with cancer is a well-known factor that affects patient prognosis for different types of cancer [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Clinical Relevance of Red Blood Cell Distribution Width (RDW) in Endometrial Cancer: A Retrospective Single-Center Experience from Korea

Eoh

Lee

Nam

et al. 2023

Cancers

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Background: Red blood cell distribution width (RDW) is a standard parameter of complete blood count and indicates the variability in red blood cell size. This study aimed to determine whether preoperative RDW can be used to predict the recurrence and prognosis of endometrial carcinoma. Methods: The medical records of 431 patients diagnosed with endometrial carcinoma were retrospectively reviewed between May 2006 and June 2018. In addition to RDW, the clinicopathological factors, survival curves, and prognoses of the patients with endometrial carcinoma were compared between the high (n = 213) and low (n = 218) groups according to the median RDW value (12.8%). Results: The patients with high RDW had significantly advanced-stage (p = 0.00) pelvic lymph node metastasis (p = 0.01) and recurrence (p = 0.01) compared to those in the low-RDW group. In univariate analysis with DFS as the endpoint, surgical stage, type II histology, grade, RDW, and lymph node metastasis were independently associated with survival. Patients with high RDW values had significantly shorter disease-free survival and overall survival than those with low RDW values (log-rank p = 0.03, log-rank p = 0.04, respectively). Conclusion: Our results demonstrate that RDW is a simple and convenient indicator of endometrial carcinoma recurrence. Prospective studies are needed to validate the findings of the current study.

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Prognostic significance of the systemic immune inflammation index in patients with metastatic and unresectable pancreatic cancer

Cited by 6 publications

References 40 publications

Investigation of the prognostic role of systemic immunoinflammatory index in patients with acute pancreatitis

Investigation of the prognostic role of systemic immunoinflammatory index in patients with acute pancreatitis

Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study

Clinical Relevance of Red Blood Cell Distribution Width (RDW) in Endometrial Cancer: A Retrospective Single-Center Experience from Korea

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