2007
DOI: 10.21608/mjfmct.2007.52486
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Prognostic Significance of Three Hepatitis Markers (P53 Antibodies, Vascular Endothelial Growth Factor And Alpha - Feto Protein) in Patients With Hepatocellular Carcinoma

Abstract: Gad El-Hak et al ... areas of the world where the prevalence of HBV infection is also high was a clue to the link between the virus and the tumor (Bosch et al., 2004). HCV cirrhosis increases the risk of HCC dramatically (Di Bisceglie, 1997). It is estimated that between 2 and 5.7 % of all INTRODUCTlON The hepatocellular carcinoma is linked to environmental, dietary and lifestyle factors, so that its incidence and distribution vary widely among ethnic groups, geographical regions and sex. The increased inciden… Show more

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Cited by 12 publications
(15 citation statements)
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“…higher in case of HCC group when compared to the control group, in a similar tendency to that reported by other researchers [30,31]. This elevation could be attributed to the continuous inflammatory state found in this group.…”
Section: Discussionsupporting
confidence: 90%
“…higher in case of HCC group when compared to the control group, in a similar tendency to that reported by other researchers [30,31]. This elevation could be attributed to the continuous inflammatory state found in this group.…”
Section: Discussionsupporting
confidence: 90%
“…Here, we report that Cbx4 increases hypoxia-induced VEGF expression in HCC cells and that Cbx4 expression is highly correlated with VEGF expression and angiogenesis in HCC tissues, of which a great ratio expresses higher levels of Cbx4 protein. Like VEGF expression (Gadelhak et al, 2009;Kaseb et al, 2011), the elevated Cbx4 protein has a positive correlation with poor outcome in HCC patients. In line with these observations, we show that Cbx4 overexpression promotes, while endogenous Cbx4 knockdown eliminates, VEGF production and angiogenesis under hypoxia, and thus tumor progression in subcutaneously and orthotopically transplanted HCC mice.…”
Section: Discussionmentioning
confidence: 99%
“…Some studies also indicate that the level of hematopoietic stem cells and endothelial progenitor cells in peripheral blood circulation increases with the stage of tumor development [10][11][12]. It is suggested that they may serve as a biomarker in the evaluation of tumor progress and prediction of treatment outcome [13][14][15][16]. However, only a few studies point to the importance of endothelial progenitor cells in the clinical evaluation of patients with liver cirrhosis and patients with hepatocellular carcinoma, so far [9,10,17,18].…”
Section: Introductionmentioning
confidence: 99%
“…The grade of tumor differentiation and the tumor histological type are the universally accepted criteria used to classify HCC, and the microvascular invasion is known to be the strongest predictor of tumor relapse in patients undergoing liver resection and liver transplantation. There is also clear evidence that the less differentiated tumor is, the higher the risk of vascular invasion to the surrounding liver tissue [7,9,[14][15][16][17][18]. Unfortunately, there is no standard method of identifying the unfavorable tumor biology likely to entail a high risk for tumor recurrence [5][6][7][8].…”
Section: Introductionmentioning
confidence: 99%