Prognostic significance of thrombocytosis, platelet parameters and aggregation rates in epithelial ovarian cancer

Abstract

Thrombocytosis, accompanied by increasing of platelet aggregation rates, is associated with more aggressive tumor biology in EOC. The combination of thrombocytosis and MAR is an independent negative prognostic factor for overall survival in EOC patients.

May the Platelet to Lymphocyte Ratio be a Prognostic Factor for Epithelial Ovarian Cancer?

“…In the only study investigated, these parameters, in terms of the prognosis of ovarian cancer in the literature, were all found to be consistently higher in women with epithelial ovarian cancer than those in the healthy or benign group (Ma et al, 2014). In line with this study, we evaluated platelet indices in terms of the stage of the disease.…”

“…Apart from the stage of the disease, many other features have been found to be significant in predicting the prognosis, such as histopathologic type, grade, age of the patient, level of serum carbohydrate antigen (CA-125) and residual tumors (Vergote et al, 1993). Several markers have been investigated by researchers to estimate the patients' outcome and, recently, alterations in white blood cells (WBC) and platelets have been the focus of many studies (Cho et al, 2009;Ma et al, 2014;Williams et al, 2014). The response of the patient to cancer has been found to be related to cytokines released from neutrophils and platelets as well as the tumor cells.…”

Platelet count and mean platelet volume in the prediction of colorectal cancer in patients presented with emergency ileus

“…Ma et al detected signifi cantly higher levels of platelet counts in high-grade tumors. In addition, platelet number, MPV and PDW was detected higher in malignant group 21 . In harmony with literature, it was identifi ed in our study that both platelet number and MPV level had been signifi cantly higher in the group where colorectal malignancy was detected among the patients operated under emergency conditions with the diagnosis of ileus.…”

Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios in patients with endometrial hyperplasia and endometrial cancer

“…Induction of platelet synthesis leading to the increased size of the platelet possibly affects platelet distribution width (PDW). The elevated platelet count and aggregation are proved to facilitate tumor cell progression by protecting them from immune responses …”