Prognostic Significance of Tissue-Type Plasminogen Activator (tPA) Content in Gastric Cancer and Surrounding Mucosa

Abstract

We found a wide variability in tPA levels in gastric carcinoma and adjacent mucosa samples, with significantly decreased levels in tumors and a significantly positive relationship between tPA levels and ER status. There was a non-monotonic relationship between tPA levels and prognosis in patients with gastric cancer.

Tissue-type plasminogen activator activity in morphologically normal tissues adjacent to gastrointestinal carcinomas is associated with the degree of tumor progression

“…According to our results, the difference between these ratios can be explained by an increase in the u-PA activity in the tumor tissues because t-PA activity does not differ significantly between tumor and ''normal tissues'' (Table 2). These results suggest an up-regulation of u-PA in the tumor tissues instead of a switch of molecular type of PA. Several works support this idea (Andreasen et al 2000;Sanz et al 2002;Baker and Leaper 2003;Diaz et al 2004;Seiler et al 2004).…”

“…In contrast, t-PA is currently considered to be mainly involved in intravascular fibrinolysis (Herszenyi et al 2000) and less relevance is usually given to it in tumor biology. Nevertheless, some reports suggest that t-PA is also involved in the tumor progression (Raigoso et al 2000;Sanz et al 2002;Diaz et al 2004).…”

“…Some studies, however, have yielded conflicting results about such a prognostic value (Fujii et al 1999;Raigoso et al 2000;Sanz et al 2002). It was reported that the level of t-PA activity or its expression could also have prognostic value since the low level of t-PA expression in the gastrointestinal mucosa is associated with a shorter overall survival (Verspaget et al 1995;Ganesh et al 1994Ganesh et al , 1996Ganesh et al , 1997.…”

Aberrant Factors of Fibrinolysis and Coagulation in Pancreatic Cancer

“…t-PA is one of the better studied compounds of the fibrinolysis pathway, which has been detected in multiple tumors, such as ovarian cancer, 32 lung cancer, 33 breast cancer, 34 glioma, 35 hepatocellular cancer, 36 laryngeal tumors, 37 malignant melanoma, 38 prostate cancer, 39 gastric cancer, 40 and colonic cancer. 41 However, t-PA antigen levels in cancer tissue varied in different tumor types.…”

Factores pronósticos y nuevos aspectos de la biología molecular en el cáncer de estómago resecable

“…Entre las proteasas cuya expresión elevada ha sido asociada con un pronóstico desfavorable en el cáncer gástrico, se encuentra la cisteín-proteasa catepsina B, las aspartil-proteasas catepsina D y E, las serín-proteasas uPA y tPA, y las metaloproteasas gelatinasa A, matrilisina, metaloproteasa de membrana tipo 1 y colagenasa-3 [19][20][21][22] . No obstante, el papel de las proteasas en la biología del cáncer es más complejo de lo que se pensaba en un principio.…”