2023
DOI: 10.15430/jcp.2023.28.4.175
|View full text |Cite
|
Sign up to set email alerts
|

Prognostic Significance of Tumor Mutation Burden among Patients with Non-small Cell Lung Cancer Who Received Platinum-based Adjuvant Chemotherapy: An Exploratory Study

Wei-Xi Shen,
Guang-Hua Li,
Yu-Jia Li
et al.

Abstract: This study aimed to investigate the prognostic significance of tumor mutation burden (TMB) among patients with non-small cell lung cancer (NSCLC) who received platinum-based adjuvant chemotherapy. Tumor tissue specimens after surgical resection were collected for DNA extraction. Somatic mutation detection and TMB analysis were conducted using next-generation sequencing (NGS). Recurrence status of the patients was assessed in the hospital during the adjuvant chemotherapy period, and long-term survival data of p… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 42 publications
0
1
0
Order By: Relevance
“…From a genetic point of view, some considerations regarding ACC can be made. First, Tumor Mutational Burden (TMB) [ 17 ] is defined as the number of non-inherited mutations per million bases (Mb) of investigated genomic sequence. TMB is reported to be low in AdCC and the most frequent DNA-mutations identified are found in NOTCH1 (25%), KDM6A, CREBP, and SMARCA2 (15%) genes.…”
Section: Adenoid Cystic Carcinoma (Adcc)mentioning
confidence: 99%
“…From a genetic point of view, some considerations regarding ACC can be made. First, Tumor Mutational Burden (TMB) [ 17 ] is defined as the number of non-inherited mutations per million bases (Mb) of investigated genomic sequence. TMB is reported to be low in AdCC and the most frequent DNA-mutations identified are found in NOTCH1 (25%), KDM6A, CREBP, and SMARCA2 (15%) genes.…”
Section: Adenoid Cystic Carcinoma (Adcc)mentioning
confidence: 99%