Prognostic significance of vascular dilation and tortuosity insufficient for plus disease in retinopathy of prematurity

Experts do not agree when to treat retinopathy of prematurity based on plus disease

“…Two new terms were defined by the revisited ICROP: pre-plus disease, a predictor of sight-threatening plus disease development; and aggressive posterior ROP (APROP), at high risk of rapidly developing into retinal detachment 9 11. Consistent recognition of both these pathologies is desirable.…”

A pilot study using “ROPtool” to quantify plus disease in retinopathy of prematurity

“…"Pre-plus disease" is defined as vascular abnormalities of the posterior pole that are insufficient for the diagnosis of plus disease but that demonstrate more arterial tortuosity and more venous dilation than normal. 3 The presence of pre-plus disease may have prognostic value, 4 and it can influence follow-up intervals or decisions to transfer infants to other hospitals. Unfortunately, judging the presence of plus disease or pre-plus disease is highly subjective and prone to error.…”

Semiautomated computer analysis of vessel growth in preterm infants without and with ROP

“…1 It comprises a constellation of signs which are superimposed on disease staging 2 that consists of venous engorgement, arteriolar tortuosity, iris vessel engorgement, pupil rigidity, and vitreous haze.…”