Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer

Guo, Xufeng; Chen, Yongbing; Xu, Zhonghua; Xu, Zhonghen; Qian, Yongyue; Yu, Xiuping

doi:10.1093/abbs/gmp004

Cited by 32 publications

(31 citation statements)

References 23 publications

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“…These results agree with several studies demonstrating that the positive expression levels of VEGF were closely associated with the tumor stage and the lymph node metastasis, correlated to patient prognosis and recommended its use for diagnosis and follow-up of patients with lung cancer [2,15,16,30].…”

Section: Discussionsupporting

confidence: 91%

“…Many investigators showed that high levels of COX-2 expressions in NSCLC tissues (especially in adenocarcinoma and squamous cell carcinoma) was associated with the degree of tumor cell differentiation and depth of invasion. They suggested that, angiogenesis is attributed to COX-2 expression, that was significantly associated with increasing expression of VEGF, production of PG-E 2 , PG-I 2 which can directly stimulate endothelial cell migration and VEGF-stimulated lymphangiogenesis besides, inhibition of apoptosis by stimulating bcl 2 and suppression of antitumor immunity [2,22,[24][25][26]. The COX-2 target therapy blocks the prostaglandins production leading to both anti-inflammatory and anti angiogenic effects.…”

Section: Discussionmentioning

confidence: 99%

“…Lung cancer is one of the most frequent and lethal malignancies worldwide, and the 5-year survival rate is only about 20% [1][2]. Non small cell lung cancer tissue produces numerous growth factors which are multifunctional [3].…”

Section: Introductionmentioning

confidence: 99%

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Emerging Prognostic Biomarkers in Non Small Cell Lung Cancer Patients:Impact of Treatment with Nimesulide (COX-2 Inhibitor) Combined with Chemotherapy

Melegy¹

2013

J Pulm Respir Med

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To date, the treatment outcome of non small cell lung cancer (NSCLC) is still not satisfactory and new treatment options are urgently needed. The present study was designed to: 1) evaluate the effects of the antiangiogenic drug; nimesulide (NSAID, a COX-2 inhibitor) combined with chemotherapy on NSCLC treatment progress, 2) Evaluate the role of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), as prognostic indicators in NSCLC, 3) Correlate the above parameters levels with the clinicopathological status of the patients during the therapy. The study included 30 NSCLC. The patients were divided to: group I, included 17 patients received chemotherapy alone and group II included 13 patients received the same chemotherapy with Nimesulide and 10 as controls. Serum and biopsies were taken for all subjects on admission and 3 weeks after the completion of treatment. Results: serum and tissue levels of VEGF and bFGF, were significantly higher in NSCLC patients and decreased significantly after treatment specially in group II compared to group I. The serum and tissue levels of the studied parameters decreased significantly in the responders as compared to resistant cases. The response rate after combined therapy was 69% versus 53% after chemotherapy alone. In conclusion, Nimesulide appears to boost the efficacy of the traditional chemotherapy as its co-administration showed encouraging effects on improving and normalization of the proangiogenic parameters levels and in turn the vascular supply of tumors. This may have good impact on the patient outcome, prolongation of their survival rate and prognosis.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Emerging Prognostic Biomarkers in Non Small Cell Lung Cancer Patients:Impact of Treatment with Nimesulide (COX-2 Inhibitor) Combined with Chemotherapy

Melegy¹

2013

J Pulm Respir Med

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“…In 2008, it claimed the lives of approximately 1.4 million people around the world (1,2) and its 5-year survival rate is ~15% (3). In the past 20 years, lung cancer mortality has increased in china, especially in urban areas and among older people; treatment outcomes remain unsatisfactory (4,5) and the mortality is high. Hence, there is great interest in studying this disease in order to better understand its biology and to translate research findings into improved therapies (6).…”

Section: Introductionmentioning

confidence: 99%

“…The human genome is estimated to contain nearly 900 unique miRNAs, which control, in part, the expression of more than one third of the human genes (7). In human cancer, several dysregulated miRNAs have been shown to have oncogenic or tumor suppressive activity (4). For example, miRNA-155 (miR-155) is overexpressed in a variety of human cancers and immune diseases (10).…”

Section: Introductionmentioning

confidence: 99%

microRNA-182 inhibits the proliferation and invasion of human lung adenocarcinoma cells through its effect on human cortical actin-associated protein

Zhang

Liu

Huang³

et al. 2011

Int J Mol Med

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Abstract. Lung cancer is one of the main causes of cancer death worldwide. The cortactin gene, CTTN, may play a pivotal role in the proliferation and invasion of tumors. A microRNA (miR-182) was cloned and used to study the expression of CTTN and its regulatory effects on the proliferation and invasion of the lung cancer cell line, A549. cortactin protein and CTTN mRNA expression decreased in A549 cells that were transfected with the miR-182 expression plasmid. A cell proliferation assay indicated that miR-182 expression affected cell cycle regulation and suppressed proliferation of lung cancer cells in vitro. In addition, xenograft experiments confirmed the suppression of tumor growth in vivo, which was due to the promotion of apoptosis. In conclusion, endogenous mature miR-182 expression may have an important role in the pathogenesis of lung cancer through its interference with the target gene CTTN by epigenetic modification.

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Pulmonary-Respiratory Medicine

2001

JAMA

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Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer

Cited by 32 publications

References 23 publications

Emerging Prognostic Biomarkers in Non Small Cell Lung Cancer Patients:Impact of Treatment with Nimesulide (COX-2 Inhibitor) Combined with Chemotherapy

Emerging Prognostic Biomarkers in Non Small Cell Lung Cancer Patients:Impact of Treatment with Nimesulide (COX-2 Inhibitor) Combined with Chemotherapy

microRNA-182 inhibits the proliferation and invasion of human lung adenocarcinoma cells through its effect on human cortical actin-associated protein

Pulmonary-Respiratory Medicine

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