Prognostic tools for visual acuity in primary rhegmatogenous retinal detachment

Abstract

Purpose: To study the influence of central retinal artery (CRA) blood velocities, intraocular pressure (IOP) and Endothelin‐1 (ET‐1) on visual acuity (VA) of primary rhegmatogenous retinal detachment (RD) Methods: This is a prospective interventional clinical study of 66 patients undergoing scleral buckling (SB) procedure, with reattachment of the retina 8 months after surgery. CRA Doppler sonography parameters and IOP were measured before SB. Immunoreactive (IR) ET‐1 was assayed (radioimmunoassay) in plasma and subretinal fluid (SRF). Snellen VA and fundus examination were checked before and 8 months after surgery. Stepwise multivariate linear regression analysis allowed us to find models for VA Results: IOP and CRA end diastolic velocity (EDV) explains preoperative VA (R2=0.509, p<0.0001). Preoperative VA, existence of PVR, CRA EDV and plasma IR‐ET‐1 (in PVR) explains postoperative VA (R2=0.908, p<0.0001). But, preoperative VA, SRF IR‐ET‐1 and plasma IR‐ET‐1 improves last model in PVR Conclusions: Preoperative VA, existence of PVR and CRA EDV explains 90% (88% in PVR) of the variability of postoperative VA, but a model with preoperative VA, SRF IR‐ET‐1 and plasma IR‐ET‐1 explains 90% of it in PVR (Supported by grants: FIS PI 040446 and DGES 97/0028)