Prognostic Utility of Geriatric Nutritional Risk Index After Curative Resection of Colorectal Cancer: A Propensity Score-matched Study

Kataoka, Masahiro; Hirano, Yasumitsu; Ishii, Toshimasa; Ishikawa, Shintaro; Kataoka, Atsuko; Fujii, Takatsugu; Shimamura, Satoshi

doi:10.21873/cdp.10064

Cited by 4 publications

(5 citation statements)

References 30 publications

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“…25 of these were selected for further analysis. Finally, ten studies were deemed eligible for inclusion in the review (18)(19)(20)(23)(24)(25)(26)(27)(28)(29).…”

Section: Resultsmentioning

confidence: 99%

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Prognostic value of the geriatric nutritional index in colorectal cancer patients undergoing surgical intervention: A systematic review and meta-analysis

Mao

Lan

2022

Front. Oncol.

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BackgroundWe reviewed the literature to assess the prognostic ability of the geriatric nutritional risk index (GNRI) for patients with colorectal cancer (CRC) undergoing curative surgery.MethodsThe online databases of PubMed, CENTRAL, ScienceDirect, Embase, and Google Scholar were searched for articles reporting the relationship between GNRI and outcomes in CRC patients. English language studies were searched up to 28th April 2022.ResultsTen studies with 3802 patients were included. Meta-analysis indicated that patients with low GNRI had significantly poor overall survival (HR: 2.41 95% CI: 1.72, 3.41 I2 = 68%) and disease-free survival (HR: 1.92 95% CI: 1.47, 2.49 I2 = 49%) as compared to those with high GNRI. The meta-analysis also indicated a significantly higher risk of complications with low GNRI as compared to high GNRI (HR: 1.98 95% CI: 1.40, 2.82 I2 = 0%). The results did not change on subgroup analysis based on study location, age group, GNRI cut-off, and sample size.ConclusionCurrent evidence indicates that GNRI can be a valuable prognostic indicator for CRC patients undergoing surgical intervention. Patients with low GNRI have poor overall and disease-free survival and a higher incidence of complications. Clinicians could use this simple indicator to stratify patients and formulate personalized treatment plans.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier (CRD42022328374).

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“…25 of these were selected for further analysis. Finally, ten studies were deemed eligible for inclusion in the review (18)(19)(20)(23)(24)(25)(26)(27)(28)(29).…”

Section: Resultsmentioning

confidence: 99%

“…Only one study by Kataoka et al ( 25 ) did not report outcomes as adjusted ratios and hence could not be included in the meta-analysis. In their study, the authors used propensity score matching to compare data of patients with low and high GNRI (cut-off 98).…”

Section: Resultsmentioning

confidence: 99%

Prognostic value of the geriatric nutritional index in colorectal cancer patients undergoing surgical intervention: A systematic review and meta-analysis

Mao

Lan

2022

Front. Oncol.

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“…Although PNI was not evaluated in the geriatric colorectal cancer group when the literature was examined, PNI, which is an indicator of immune nutritional status, was found to be higher in the group under 65 years of age. In the geriatric population, the Geriatric Nutrition Risk Index (GNRI) calculated by using body weight and albumin instead of PNI was established, and survival and prognosis were found to be better in those with higher levels [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of immune-nutritional status in metastatic colorectal cancer: Prognostic Nutritional Index (PNI)

Keskinkilic,

Semiz,

Ataca

et al. 2024

Support Care Cancer

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Backround and purpose A low Prognostic Nutritional Index (PNI) value, which reflects immune nutrition and inflammation around the tumor, is associated with an unfavorable prognosis, and it was aimed to reveal its prognostic value in metastatic colorectal cancer (CRC). Methods In our retrospective cross-sectional study, patients with a diagnosis of metastatic colorectal disease without active infection, between January 2010 and December 2016 were included. The PNI values at the time of diagnosis were calculated according to the formula (10 × serum albumin (g/dL)) + (0.005 × total lymphocyte value). Results The mean PNI value of 253 patients included in the study was 46.6. While 53.75% (n = 136) of the patients had a PNI value of 46.6 and above, 46.25% (n = 117) had a PNI value below 46.6. The overall survival (OS) of the group with a PNI of 46.6 and above was statistically significantly longer (53.06 months vs 38.80 months, p = 0.039). The PFS duration of the group with PNI below 46.6 was 25.66 months, while the PFS duration of the group with PNI above 46.6 was not reached (p = 0.265). Conclusion PNI is a simple and inexpensive index that evaluates the immunonutritional status, and it is a prognostic marker that can be easily used in patients with metastatic colorectal cancer as in other cancer types.

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“…Body weight, height, and blood samples were obtained from each patient within 2 weeks before the start of neoadjuvant treatment (pre-treatment) and within 1 week before radical resection (post-treatment). Cut-off values (<98) for GNRI low and high groups were determined according to previous reports (13,(17)(18)(19)(20).…”

Section: Patientsmentioning

confidence: 99%

“…GNRI is calculated using serum albumin levels and the patient's height and body weight, making it objective and easy to use in clinical practice. Since its inception, various studies have shown the prognostic value of GNRI for patients with a range of gastrointestinal cancers (14)(15)(16), including colorectal cancer (17)(18)(19)(20)(21). A recent meta-analysis of 10 studies and a total of 3,802 colorectal cancer patients showed low GNRI to be signi cantly associated with poorer overall survival and disease-free survival (22).…”

Section: Introductionmentioning

confidence: 99%

Geriatric nutritional risk index after neoadjuvant chemoradiotherapy and survival in older patients with advanced rectal cancer

Amano

Akiyoshi

Furuta

et al. 2023

Int J Colorectal Dis

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PurposeTo investigate the clinical impact of malnutrition on survival in older patients with advanced rectal cancer undergoing neoadjuvant chemoradiotherapy.Methods We investigated the clinical signi cance of the geriatric nutrition risk index (GNRI) in 237 patients older than 60 with clinical stage II/III rectal adenocarcinoma treated with neoadjuvant longcourse chemoradiotherapy or total neoadjuvant therapy followed by radical resection from 2004 to 2017.Pre-treatment and post-treatment GNRI were evaluated, and patients were divided into low (<98) and high (≥98) GNRI groups. The prognostic impact of pre-treatment and post-treatment GNRI levels on overall survival and disease-free survival were evaluated using univariate and multivariate analyses.Results Fifty-seven patients (24.1%) before neoadjuvant treatment and 94 patients (39.7%) after neoadjuvant treatment were categorized as low GNRI. Pre-treatment GNRI levels were not associated with overall survival (p = 0.80) or disease-free survival (p = 0.77). Patients in the post-treatment low GNRI group had signi cantly poorer overall survival than those in the post-treatment high GNRI group (p = 0.0005). The multivariate analysis showed that post-treatment low GNRI levels were independently associated with poorer overall survival (hazard ratio, 3.25; 95% con dence interval, 1.26-8.36; p = 0.02). Although post-treatment GNRI levels were not associated with disease-free survival (p= 0.24), among the 50 patients with recurrence, post-treatment low GNRI levels were associated with poorer post-recurrence survival (p = 0.006). ConclusionPost-treatment GNRI is a promising nutritional score associated with overall survival and post-recurrence survival in older patients with advanced rectal cancer treated with neoadjuvant chemoradiotherapy.

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Prognostic Utility of Geriatric Nutritional Risk Index After Curative Resection of Colorectal Cancer: A Propensity Score-matched Study

Cited by 4 publications

References 30 publications

Prognostic value of the geriatric nutritional index in colorectal cancer patients undergoing surgical intervention: A systematic review and meta-analysis

Prognostic value of the geriatric nutritional index in colorectal cancer patients undergoing surgical intervention: A systematic review and meta-analysis

The prognostic value of immune-nutritional status in metastatic colorectal cancer: Prognostic Nutritional Index (PNI)

Geriatric nutritional risk index after neoadjuvant chemoradiotherapy and survival in older patients with advanced rectal cancer

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