Prognostic utility of Ki-67 in gastric carcinoma

Almabrouk, Naema Mohamed; El-Maraghy, Maissa N.; Badr, Ahmed Mohy Eldin; Meckawy, Ghada Refaat; Shakweer, Marwa M

doi:10.34172/ipp.2022.14

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…A study conducted by Halder A et a l (2018) [19] reported high Ki67 was associatedwith depth of tumor invasion . Thus, a significant inverse association between Ki-67 expression and depth of tumor invasion was detected in the current study [20,21].…”

Section: Discussionsupporting

confidence: 61%

CDX2 and Ki-67 Expression in Gastric Carcinoma and Its Association with Clinocopathological Parameters

Pranjali

Sulatha

Vijaya

2022

Asian Pac J Cancer Biol

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Background: CDX2 has been established as a good prognostic marker for colorectal carcinomas. Differentiated adenocarcinomas are characterized by higher CDX2 expression than undifferentiated tumors with stronger reactivity in intestinal phenotypes. There is a close correlation between the degree of tumor differentiation and the Ki-67 score. It was also observed that strong CDX2 expression was associated with low Ki-67 index whereas negative or dim CDX2 expression was associated with high Ki-67 index. Methods: Gastric biopsies and gastrectomy specimens with gastric carcinoma were evaluated clinicopathologically and processed for immunohistochemistry (IHC) staining to assess CDX2 and Ki-67 expression. The relationship between 2 markers and each clinicopathological parameter was evaluated. Data was statistically analysed. P<0.05 were taken for statistical significance. Results: The study was done on 57 gastric adenocarcinoma cases with mean age 56.12 years. No significant correlation was found between CDX2 & Ki-67 with clinical, gross & microscopic parameters except for tumor location and depth of invasion. Significant correlation was detected between CDX2 (p=0.04) & Ki-67 (p=0.03) with tumor location. Depth of tumor invasion was significantly associated with Ki-67 (p=0.013). No significant association between CDX2 and Ki-67 was observed. Conclusion: The statistical correlation between CDX2 & Ki-67 with clinicopathological parameters proves that CDX2 & Ki-67 to be the independent markers with respect to tumor site and depth of invasion (in case of Ki-67). But due to lack of association of CDX2 with Ki-67 further studies need to be done with higher sample size.

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Section: Discussionsupporting

confidence: 61%

CDX2 and Ki-67 Expression in Gastric Carcinoma and Its Association with Clinocopathological Parameters

Pranjali

Sulatha

Vijaya

2022

Asian Pac J Cancer Biol

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“…При анализе данной работы мы пришли к выводу, что полученные результаты, возможно, были связаны с низким выбором порогового значения индекса Ki-67, который составил > 25 %, а также гетерогенностью групп исследования. Следует отметить, что авторы ссылаются в данном исследовании на корреляцию индекса Ki-67 < 25 % со степенью инвазии T3-4, низкой дифференцировкой опухоли, диффузным типом по Lauren, лимфоваскулярной и периневральной инвазией, которые в свою очередь являются факторами неблагоприятного прогноза [25,[33][34][35][36]. В тоже время в работе других исследователей продемонстрирована высокая связь гиперэкспрессии Ki-67 с ухудшением общей выживаемости пациентов с РЖ (HR = 1,51; 95 % CI 1,31-1,72) [37].…”

Section: общая выживаемость % время месяцыunclassified

Determination of the Ki-67 threshold value for predicting lymph nodes involvement in patients with gastric cancer

Ashimov,

Chichevatov,

Radovsky

et al. 2024

Malignant Tumours

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The search for biological markers to assess metastatic involvement of the lymph nodes in gastric cancer is one of the key steps in determining treatment tactics. The role of Ki-67 as a marker of cell proliferation in gastric cancer remains relevant. The aim of our study is to determine the Ki-67 threshold value for predicting the lymph nodes metastases. A retrospective analysis of 154 patients with gastric cancer showed an independent and statistically significant relationship between the depth of tumor invasion T (p = 0.002), the differentiation grade G (p = 0.010), the value of the Ki-67 index (p < 0.0001) and metastatic involvement of the lymph nodes. Using ROC analysis we found that Ki-67 ≥ 45 % correlates with the optimal level of sensitivity (55.9 %), specificity (84.2 %) and accuracy (73.4 %) of the method AUC 0.738 (p >< 0.043; 95 % CI 0,654–0,823). When evaluating the overall survival of patients>< 0.0001) and metastatic involvement of the lymph nodes. Using ROC analysis we found that Ki-67 ≥ 45 % correlates with the optimal level of sensitivity (55.9 %), specificity (84.2 %) and accuracy (73.4 %) of the method AUC 0.738 (p < < 0.043; 95 % CI 0,654–0,823). When evaluating the overall survival of patients >0.043; 95 % CI 0,654–0,823). When evaluating the overall survival of patients with Ki-67 > 45 %, we found that the median OS was 32 months [HR 2.2; 95 % CI 1.2–3,9; p = 0.005], while it was not reached in the group with Ki-67 < 45 %.A Ki-67 level of ≥ 45 % is the optimal threshold for determining the likelihood of lymph node metastasis in gastric cancer.

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Expression of Her-2 and Ki-67 in Gastric Cancer Formalin Fixed Paraffin Embedded Tissue Blocks and Their Correlation with Histological Grades at the Uganda Cancer Institute Pathology Laboratory

Wasswa,

Birungi,

Amadile

et al. 2024

PLMI

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Prognostic utility of Ki-67 in gastric carcinoma

Cited by 4 publications

References 22 publications

CDX2 and Ki-67 Expression in Gastric Carcinoma and Its Association with Clinocopathological Parameters

CDX2 and Ki-67 Expression in Gastric Carcinoma and Its Association with Clinocopathological Parameters

Determination of the Ki-67 threshold value for predicting lymph nodes involvement in patients with gastric cancer

Expression of Her-2 and Ki-67 in Gastric Cancer Formalin Fixed Paraffin Embedded Tissue Blocks and Their Correlation with Histological Grades at the Uganda Cancer Institute Pathology Laboratory

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