Prognostic utility of NT-proBNP in acute exacerbations of chronic pulmonary diseases

Cardiac biomarkers predict outcome after hospitalisation for an acute exacerbation of chronic obstructive pulmonary disease

“…We are aware that our results need to be interpreted against the particular features of our study. A study sample may be considered as small but it is in line with several previous reports in the field, particularly those of prospective design [8][9][10][11]20]. We did not adjust for potential protective effects of various cardiovascular drugs, e.g.…”

“…Primary data come from the study by Stolz et al [9], who did not show any association between brain natriuretic peptides and short-or long-term outcome after an acute exacerbation of COPD. Contrary to this report, two prospective studies using NTproBNP and mid-regional proatrial natriuretic peptide reported an association with one and two year mortality [10,11]. In line with biomarker development and comprehensive assessment, Chang et al studied both TnT and NT-proBNP in 244 patients admitted with an acute exacerbation of COPD [12].…”

“…A growing body of evidence supports the importance of cardiac biomarkers in risk stratification of acutely deteriorated or stable patients with COPD [5][6][7][8][9][10][11][12]. Of those, natriuretic peptides and troponin are the best investigated.…”

“…Several studies have demonstrated an association between cardiac laboratory biomarkers and survival in patients managed for an acute exacerbation of COPD [5][6][7][8][9][10][11][12]. Much more limited information is available, however, for the prediction of rehospitalisations.…”

NT-proBNP Is Predictive of the Weaning from Continuous Renal Replacement Therapy

“…Thus, the NT-proBNP levels mainly reflect heart function (James et al 2003;Pfister et al 2008) even though relationships with other organ functions also exist (Medina et al 2011;Colbert et al 2015). Accordingly, heart function can affect the relationship between the NT-proBNP level and weaning outcome.…”