Prognostic Utility of the Combination of Platelet Count with Neutrophil-to-Lymphocyte Ratio in Aged Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Abstract

Background and Aim. Acute myocardial infarction represents the vital cause of cardiac death, and many measurable biomarkers have been reported to be related to the prognosis of acute myocardial infarction. Our study was to investigate the role of a novel biomarker, the combination of platelet count, and neutrophil-to-lymphocyte ratio, for predicting in-hospital and long-term mortality of aged patients with acute myocardial infarction. Method. This was a study recording 637 patients who were diagnosed with acute myocardial infarction. Our patients were grouped according to the combination of platelet count and neutrophil-to-lymphocyte ratio. The prognostic role of the combination of platelet count and neutrophil-to-lymphocyte ratio on mortality was assessed by the univariate and multivariate Cox regression analysis. Result. Our study population was divided into three parts according to the median values of platelet count and neutrophil-to-lymphocyte ratio. It was indicated that platelet count and neutrophil-to-lymphocyte ratio were correlative mutually to a certain degree ( p = 0.010 ). The Kaplan–Meier analysis showed that the combination of high platelet count and high neutrophil-to-lymphocyte ratio had a greater risk of death in short- and long-term endpoints (log-rank p = 0.046 , p < 0.001 , respectively). Moreover, by multivariate analysis, both high platelet count and high neutrophil-to-lymphocyte ratio groups were an independent predictor (hazard ratio: 2.132, 95% confidence interval: 1.020–4.454, p = 0.044 ) and long-term mortality (hazard ratio: 2.791, 95% confidence interval: 1.406–5.538, p = 0.003 ). Conclusion. The combination of platelet count and neutrophil-to-lymphocyte ratio could be a useful predictor for the prediction of in-hospital and long-term mortality in aged patients with acute myocardial infarction.

Neutrophil to lymphocyte ratio as a prognostic marker for cardiovascular outcomes in patients with ST-segment elevation myocardial infarction after percutaneous coronary intervention: A systematic review and meta-analysis

“…respectively. Out of 35 observational studies, there were 34 retrospective or prospective studies [12–45] and 1 cross-sectional study. [46] These 35 observational studies enrolled a total population of 28,756 participants, out of which 9678 patients had high NLR and 13,105 patients had low NLR, while one study didn’t specify high NLR and low NLR participants.…”

Combination of White Blood Cell Count to Mean Platelet Volume Ratio and Neutrophil-to-Platelet Ratio Predicts Long-Term Adverse Events in Patients with MINOCA

“…The pathophysiologic mechanism of different etiologies of MINOCA has been described, including atherosclerotic plaque disruption, coronary vasospasm, microvascular dysfunction, spontaneous coronary dissection, and supply-demand imbalance [ 2 , 6 ]. The potential role of inflammation in the etiology of CAD, atherosclerotic coronary plaque instability, and thrombus formation has been established earlier [ 30 , 31 ]. The components of complete blood count and the derived parameters, particularly WBC count, MPV, WMR, NPR, NLR, and PLR, have been evaluated as inflammation risk factors to explore their role and predictive ability in CAD.…”

Red blood cell distribution width/platelet ratio on admission as a predictor for in-hospital mortality in patients with acute myocardial infarction: a retrospective analysis from MIMIC-IV Database

“…Several previous studies [12,13] had shown that a decreased platelet count was associated with the severity of MI, death and reinfarction. However, the relationship between platelet counts and the prognosis of MI was controversial [14][15][16][17][18].…”