Prognostic Utility of Vitamin D in Acute Coronary Syndrome Patients in Coastal Norway

Naesgaard, Patrycja A; Pönitz, Volker; Aarsetoey, Hildegunn; Brügger-Andersen, Trygve; Grundt, Heidi; Harris, William S.; Staines, Harry; Nilsen, Dennis W

doi:10.1155/2015/283178

Cited by 10 publications

(15 citation statements)

References 31 publications

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“…We chose a cut-off level of 40 nmol/L for vitamin D, based on a report by Ross et al ( 12 ), claiming that a vitamin D concentration above this level will meet the needs of 50% of the population. As demonstrated previously ( 10 ), patients in the lower vitamin D group had a significant lower survival rate than those with levels above 40 nmol/L. These differences were maintained when assessing the total population according to gender.…”

Section: Discussionsupporting

confidence: 79%

“…Furthermore, the subtropical location of Salta, Argentina, is associated with a higher exposure to sun in comparison to that of the temperate location of Norway. Our two patient populations were divided into 25(OH)D quartiles, comparing patients with high and low levels of vitamin D. We found that vitamin D was an independent prognostic biomarker in relation to total mortality and cardiac death in the Argentinean population, whereas in the Norwegian population its prognostic utility was less evident, but with a clear trend supporting the findings obtained in the Argentinean study ( 9 , 10 ).…”

Section: Introductionsupporting

confidence: 79%

“…Limitations have previously been described ( 9 , 10 ) and consist mainly of one set of blood samples at admission and no measurements of parathyroid hormone. As this is an observational study, unknown and residual confounders may have been missed.…”

Section: Discussionmentioning

confidence: 99%

“…The details, including blood sampling procedures, laboratory measurements, and exclusion criteria of the RACS and ARRA-RACS studies, have been published previously ( 9 , 10 , 15 ).…”

Section: Methodsmentioning

confidence: 99%

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Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome

Naesgaard

Fuente

Nilsen

et al. 2016

Front. Cardiovasc. Med.

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BackgroundSeveral studies have demonstrated an association between low vitamin D levels and cardiovascular risk. Vitamin D cut-off levels are still under debate.ObjectivesTo assess two cut-off levels, 40 and 70 nmol/L, respectively, for vitamin D measured as 25-hydroxyvitamin D in chest pain patients with suspected acute coronary syndrome.MethodsWe investigated 1853 patients from coastal-Norway and inland Northern-Argentina. A similar database was used for pooling of data. Two-year follow-up data including all-cause mortality, cardiac death, and sudden cardiac death in the total patient population were analyzed, applying univariate and multivariable analysis.ResultsTwo hundred fifty-five patients with known vitamin D concentrations died. In the multivariable analysis, there was a decrease in total mortality above a cut-off level of 40 nmol/L and a decrease in cardiac death above a cut-off level of 70 nmol/L [HRs of 0.66 (95% CI, 0.50–0.88), p = 0.004 and 0.46 (95% CI, 0.22–0.94), p = 0.034, respectively].ConclusionVitamin D cut-off levels of 40 and 70 nmol/L were related to total mortality and cardiac death, respectively.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

“…The details, including blood sampling procedures, laboratory measurements, and exclusion criteria of the RACS and ARRA-RACS studies, have been published previously ( 9 , 10 , 15 ).…”

Section: Methodsmentioning

confidence: 99%

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Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome

Naesgaard

Fuente

Nilsen

et al. 2016

Front. Cardiovasc. Med.

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“…According to recent studies, there is a correlation between vitamin D concentrations and risk factors for coronary artery syndrome such as dyslipidemia, hypertension, obesity, diabetes mellitus, and inflammatory factors. 2 – 5 In addition, 25(OH)D deficiency is common among patients with ACS and associated with increased risk of ACS complications. 6 It has been suggested that left ventricular ejection fraction (LVEF), as a reliable indicator in ventricular dysfunction, has been affected more severely among patients with ACS who have low serum vitamin D concentration.…”

Section: Introductionmentioning

confidence: 99%

The association of serum vitamin D concentration and ventricular dysfunction among patients with acute coronary syndrome

Khademvatani¹,

Mohammadzad²,

Yekta

et al. 2017

TCRM

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ObjectiveTo determine if vitamin D deficiency was associated with higher odds of left ventricular dysfunction among patients with acute coronary syndrome (ACS) and, if so, to determine whether this association was mediated by increased inflammation as measured by C-reactive protein (CRP) and white blood cell count (WBC).MethodsThis was a cross-sectional study of 170 participants with ACS. Multiple logistic regression was used to examine the association between the outcome of ventricular performance and serum vitamin D concentrations. We also determined whether CRP and WBC meet standard criteria as the mediators between left ventricular ejection fraction and vitamin D deficiency.ResultsParticipants with vitamin D deficiency were more likely to have ventricular dysfunction (OR: 2.12, 95% CI: 1.2–5.23). WBC counts did not meet one of the criteria for mediation. However, the WBC was an effect modifier such that the association of vitamin D deficiency and ventricular dysfunction was only present among participants with WBC more than 11,000.ConclusionThis study found that vitamin D deficiency was associated with higher odds of ventricular dysfunction. Further longitudinal and experimental studies are necessary to confirm this finding and to determine if there is a role for vitamin D supplementation therapy in preventing ventricular dysfunction in select patient populations.

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Vitamin D and Its Role on Inflammation, Oxidative Stress and Cardiovascular Disease

Barbalho,

Sloan,

Araujo

et al. 2024

Advances in Biochemistry in Health and Disease

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Prognostic Utility of Vitamin D in Acute Coronary Syndrome Patients in Coastal Norway

Cited by 10 publications

References 31 publications

Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome

Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome

The association of serum vitamin D concentration and ventricular dysfunction among patients with acute coronary syndrome

Vitamin D and Its Role on Inflammation, Oxidative Stress and Cardiovascular Disease

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