Prognostic value and association of the age-adjusted Charlson Comorbidity Index with sarcopenia within patients with gastric cancer after radical resection

Shao, Jiancan; Gao, Zekan; Shen, Qingzheng; Zhi, Huaiqing; Wang, Xiang; Zheng, Jingwei; Chen, Yajin; Shi, Ang; Wu, Dongze; Cai, Wanda; Chen, Xiaodong; Shen, Xian

doi:10.1016/j.gassur.2024.04.027

Cited by 2 publications

(1 citation statement)

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“…Cancer patients are commonly subjected to a variety of tumor specific and non-tumor specific factors, leading to the loss of muscle mass and muscle dysfunction, including age, malnutrition, cancer derived factors, cancer therapy and supportive treatment ( 25 ). Sarcopenia can affect the long-term prognosis of a variety of tumors, including oesophageal cancer ( 26 ), head and neck tumors ( 27 ), malignant lymphoma ( 28 ), gastric cancer ( 29 ), liver cancer ( 30 ). Meanwhile, studies have reported that sarcopenia is associated with postoperative complications in patients with cholangiocarcinoma after hepatectomy ( 31 ), which also increases the postoperative complications in patients with gastric cancer ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Influence of sarcopenia on postoperative complications and long-term survival in pancreatic cancer patients undergone pancreaticoduodenectomy

Qu,

Zhou,

Zhang

et al. 2024

Front. Nutr.

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BackgroundSarcopenia has the potential to impact the postoperative results and extended prognosis of various types of tumors. Nevertheless, the specific impact of sarcopenia on the postoperative results and long-term survival of pancreatic cancer (PC) following pancreaticoduodenectomy (PD) remains inadequately elucidated. This study investigates the significance of sarcopenia according to various Asian standards on postoperative complications and long-term prognosis in PC patients who have undergone PD.MethodsThis retrospective study systematically analyzed patients with PC who underwent PD from January 2015 to December 2022. Sarcopenia was diagnosed by the skeletal muscle index (SMI) obtained by the skeletal muscle area normalized for height squared on the third lumbar vertebra on computed tomography (CT) images. Univariate and multivariate logistic regression analysis were performed to analyze the correlation between sarcopenia and postoperative complications, while Cox regression analysis was utilized to explore the influence of sarcopenia on overall survival (OS) and recurrence-free survival (RFS) in PC patients after PD.ResultsWe enrolled 162 patients with PC after PD (92 males and 70 females, mean age: 63.78 ± 10.27 years), including 83 and 79 patients with sarcopenia and non-sarcopenia, respectively. Compared with non-sarcopenia patients, sarcopenia exhibited higher rates of recurrence rate (75% versus 59%, p = 0.039). Univariate and multivariate logistic regression analysis showed that sarcopenia did not affect the incidence of complications in patients with PC after PD in three Asian sarcopenia criteria. Multivariate Cox regression analysis indicated that sarcopenia was an independent risk factor for OS (hazard ratio [HR]: 2.49, 95% confidence interval [CI]: 1.73–3.60, p < 0.001) and RFS(hazard ratio [HR]: 1.70, 95%confidence interval [CI]: 1.12–2.50, p = 0.012) of PC patients with PD in Japanese Society of Hepatology criteria. Meanwhile, according to the Asian pancreatic cancer population standard, sarcopenia is an independent risk factor affecting the long-term OS (hazard ratio [HR]: 2.59, 95% confidence interval [CI]: 1.80–3.70, p < 0.001) and RFS (hazard ratio [HR]: 2.00, 95% confidence interval [CI]: 1.36–3.00, p < 0.001) of PC after PD. While sarcopenia is recognized as a risk factor for OS (hazard ratio [HR]: 1.81, 95% confidence interval [CI]: 1.08–3.10, p = 0.025) in PC patients based on the Fujiwara criteria, it is not found to be associated with RFS (hazard ratio [HR]: 1.60, 95% confidence interval [CI]: 0.90–3.00, p = 0.10). The model based on sarcopenia and clinical characteristics has high predictive ability for OS and RFS.ConclusionVarious Asian diagnostic criteria do not link sarcopenia with postoperative complications in PC patients after PD. Nevertheless, sarcopenia remains a significant independent risk factor for long-term survival, and its combination with clinical characteristics can aid clinicians in predicting long-term survival outcomes.

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