Prognostic Value and Clinicopathology Significance of MicroRNA-200c Expression in Cancer: A Meta-Analysis

Wu, Jianchun; Fang, Zhihong; Xu, Jianing; Zhu, Weikang; Li, Yan; Yu, Yongchun

doi:10.1371/journal.pone.0128642

Cited by 6 publications

(8 citation statements)

References 47 publications

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“…We found an association of miR-200c with bone metastasis, PSA level > 10.0 ng/μL, and bilateral tumor. In agreement with Wu et al [ 68 ] and Bryant et al [ 69 ], we suggested that this miRNA is a potential prognostic marker for PCa.…”

Section: Discussionsupporting

confidence: 93%

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Circulating mRNAs and miRNAs as candidate markers for the diagnosis and prognosis of prostate cancer

et al. 2017

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Circulating nucleic acids are found in free form in body fluids and may serve as minimally invasive tools for cancer diagnosis and prognosis. Only a few studies have investigated the potential application of circulating mRNAs and microRNAs (miRNAs) in prostate cancer (PCa). The Cancer Genome Atlas (TCGA) database was used for an in silico analysis to identify circulating mRNA and miRNA as potential markers of PCa. A total of 2,267 genes and 49 miRNAs were differentially expressed between normal and tumor samples. The prediction analyses of target genes and integrative analysis of mRNA and miRNA expression revealed eleven genes and eight miRNAs which were validated by RT-qPCR in plasma samples from 102 untreated PCa patients and 50 cancer-free individuals. Two genes, OR51E2 and SIM2, and two miRNAs, miR-200c and miR-200b, showed significant association with PCa. Expression levels of these transcripts distinguished PCa patients from controls (67% sensitivity and 75% specificity). PCa patients and controls with prostate-specific antigen (PSA) ≤ 4.0 ng/mL were discriminated based on OR51E2 and SIM2 expression levels. The miR-200c expression showed association with Gleason score and miR-200b, with bone metastasis, bilateral tumor, and PSA > 10.0 ng/mL. The combination of circulating mRNA and miRNA was useful for the diagnosis and prognosis of PCa.

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Section: Discussionsupporting

confidence: 93%

“…A positive correlation was observed between miR-200c and GS; the higher expression levels of miR-200c, the higher the GS. According to Wu et al [ 68 ] miR-200c is a good candidate marker for PCa detection. We found an association of miR-200c with bone metastasis, PSA level > 10.0 ng/μL, and bilateral tumor.…”

Section: Discussionmentioning

confidence: 99%

Circulating mRNAs and miRNAs as candidate markers for the diagnosis and prognosis of prostate cancer

et al. 2017

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“… 15 The following items were extracted: 1) publication details, such as the first author’s name and the publication year; 2) the characteristics of the studied population, including ethnicity, type of disease, detected sample, design of the study, detection method, cutoff definition, and follow-up time; and 3) HR of miR-150 expression for OS and PFS along with the 95% CI and P -value. If HRs were not reported in the article, we used Engauge Digitizer Version 4.1 (free software downloaded from http://sourceforge.net ) 16 to read the Kaplan–Meier survival curves to obtain the HRs and their 95% CIs. If there were insufficient data, controversies, or any other uncertainties in an article that might be related to our meta-analysis, we asked the corresponding authors for additional information.…”

Section: Methodsmentioning

confidence: 99%

Prognostic role of microRNA-150 in various carcinomas: a meta-analysis

Wang¹,

Wang²,

Zhang³

et al. 2016

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ObjectiveMicroRNA-150 (miR-150) was revealed to be an attractive prognostic biomarker in recent studies. However, the prognostic significance of miR-150 expression in cancer remains inconclusive. The aim of this study was to summarize the global predicting role of miR-150 in survival in patients with various carcinomas.MethodsEligible studies were identified through multiple search strategies. Data were extracted from the studies by investigating the relationship between miR-150 expression and survival in patients with cancer. A meta-analysis of the hazard ratio (HR) was then performed to evaluate the prognostic role of miR-150 in different tumors. Pooled HRs of miR-150 for overall survival and progression-free survival were calculated to measure the effect of miR-150 expression on prognosis.ResultsThis meta-analysis included nine published studies concerning various carcinomas. Our results indicate that an elevated miR-150 expression is associated with an enhanced overall survival in the digestive tract cancer subgroup (HR =0.57, 95% confidence interval [CI]: 0.37–0.90) and a poor progression-free survival in various cancers (HR =3.08, 95% CI: 2.00–4.75).ConclusionmiR-150 may have the potential to become a new useful prognostic factor to monitor cancer prognosis and progression. However, given the current insufficient relevant data, further clinical studies are needed.

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“…Bootstrap re-sampling procedures were applied to investigate the association between SIRT1 expression and TNM stage in order to get robust and reproducible results [ 23 ] ( Supplementary Excel File S1 ). One randomly generated results are summarized in Supplementary Excel File S2 .…”

Section: Resultsmentioning

confidence: 99%

“…Only the biomarkers that more than two studies reported could be included in our clinicopathologic analysis. Bootstrap re-sampling procedure was used to validate the association between SIRT1 expression and TNM stage as we described previously [ 23 ]. The re-sampling statistic program was displayed in Supplementary Excel File S1 .…”

Section: Methodsmentioning

confidence: 99%

Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma

et al. 2016

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The clinical value of SIRT1 in hepatocellular carcinoma (HCC) remains controversial. This meta-analysis was performed to investigate the prognostic and clinicopathological significance of the histone deacetylase SIRT1 in HCC. Pooled hazard ratios (HRs) for survival outcomes and pooled odds ratios (ORs) for clinical parameters associated with SIRT1 were calculated in nine studies using Review Manager. Meta-analysis showed that increased SIRT1 expression is associated with poor overall survival (OS) (HR=1.82, 95% confidence interval (CI): 1.49-2.22, P<0.00001) and disease-free survival (DFS) (HR=1.44, 95%CI: 1.06-1.96, P=0.02) in HCC. Increased expression of SIRT1 is more common in female than male HCC patients (OR=0.47, 95%CI: 0.32-0.70, P=0.0001). The increased SIRT1 expression correlates with hepatitis B virus (HBV) infection (OR=1.63, 95%CI: 1.04-2.57, P=0.03), large tumor size (OR=1.81, 95%CI: 1.05-3.13, P=0.03), high p53 expression (OR=2.71, 95%CI: 1.39-5.29, P=0.003), high levels of alpha-fetoprotein (AFP; cutoff value: 400 ng/ml, OR=1.84, 95%CI: 1.26-2.69, P=0.002), and tumor stage (OR=1.72, 95%CI: 1.27-2.32, P=0.0004). Re-sampling statistics for 5,000,000 samples revealed that increased SIRT1 expression is associated with higher TNM stage (OR=1.70, 95%CI: 1.69-1.70, P<0.00001). These results indicate that SIRT1 is a new biomarker off HCC as well as a potentially effective therapeutic target.

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Prognostic Value and Clinicopathology Significance of MicroRNA-200c Expression in Cancer: A Meta-Analysis

Cited by 6 publications

References 47 publications

Circulating mRNAs and miRNAs as candidate markers for the diagnosis and prognosis of prostate cancer

Circulating mRNAs and miRNAs as candidate markers for the diagnosis and prognosis of prostate cancer

Prognostic role of microRNA-150 in various carcinomas: a meta-analysis

Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma

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