Prognostic Value And Daily Trend Of Interleukin-6, Neutrophil CD64 Expression, C-Reactive Protein And Lipopolysaccharide-Binding Protein In Critically Ill Patients: Reliable Predictors Of Outcome Or Not?

Djordjević, Dragan; Pejović, Janko; Šurbatović, Maja; Jevdjić, Jasna; Radaković, Sonja; Veljović, Milić; Perić, Aneta; Andjelic, Tamara; Popović, Nikola

doi:10.1515/jomb-2015-0002

Cited by 28 publications

(30 citation statements)

References 47 publications

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“…In our present study, C-reactive protein levels showed statistically significant difference between survivors and nonsurvivors only on the 5 th day, which is, from the clinical point of view, rather late predictor of lethal outcome with AUC of 0.64. On the 1 st and 3 rd day, there were no statistically significant differences in C-reactive protein levels between survivors and nonsurvivors, which is in accordance with our previous study demonstrating AUC for this biomarker being <0.55, so C-reactive protein failed to predict lethal outcome in a similar patient population (27).…”

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confidence: 90%

Composite bioscore is superior to routine biomarkers and established scoring systems in predicting mortality in adult critically ill patients with secondary sepsis

et al. 2021

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Introduction: Sepsis represent significant global burden, with estimated 48.9 million cases and 11.0 million sepsis-related deaths recently recorded worldwide. Aim of our prospective, observational study was to assess prognostic value of some readily available routine biomarkers: presepsin, procalcitonin, C-reactive protein (CRP), white blood cell (WBC) count, platelet count, mean platelet volume (MPV) and lactate as well as their combination regarding outcome in a cohort of critically ill adult patients with secondary sepsis.Methods: Total of 86 critically ill patients with secondary sepsis due to peritonitis, pancreatitis and severe trauma, admitted to surgical intensive care unit, were enrolled in prospective study. Blood samples for biomarker analysis were collected in three time-points: on admission -1 st day, 3 rd and 5 th day. The Sequential Organ Failure Assessment (SOFA) score, the Simplified Acute Physiology Score (SAPS) II and the Acute Physiology and Chronic Health Evaluation (APACHE) II score were calculated and recorded within the first 24 hours after admission (1 st day). SOFA and SAPS II scores were recorded daily. Primary end-point was hospital mortality. Results:Values of each applied score were, expectedly, significantly higher in nonsurvivors in all timepoints. Regarding investigated parameters, only presepsin levels were significantly higher in nonsurvivors in all time-points; MPV levels on 3 rd and 5 th day; serum lactate levels on 3 th day; CRP levels and WBC count on 5 th day.Clinical accuracy of parameters in predicting lethal outcome was investigated in all time-points. On the 1 st day, apart from all three scores, only presepsin demonstrated statistically significant discriminative power regarding outcome (AUC of 0.670). Apart from SAPS II and SOFA score, on 3 rd day presepsin, MPV and lactate (AUCs of 0.716, 0.667, and 0.642 respectively) and on 5 th day presepsin, MPV, CRP and WBC count (AUCs of 0.790, 0.681, 0.643 and 0.654 respectively) were good predictors of lethal outcome. Composite bioscore (presepsin, MVP and lactate) on 3 rd day had highest AUC of 0.820 in comparison with individual scores and parameters.Independent predictor of lethal outcome on 1 st day was presepsin (p<0.05) and on 3 rd day MPV (p<0.01). Conclusion:Composite bioscore is superior to routine biomarkers and established scoring systems in prediction of mortality in adult critically ill patients with secondary sepsis.Uvod: Sepsa predstavlja značajano globalno opterećenje, sa procenjenih 48.9 miliona slučajeva i 11 miliona smrtnih slučajeva povezanih sa sepsom godišnje širom sveta. Cilj naše prospektivne, opservacione studije je bio da se proceni prognostička vrednost nekih lako dostupnih, rutinskih biomarkera kao što su: presepstin, prokalcitonin, C-reaktivni protein (CRP), broj leukocita, srednji volumen trombocita (MPV) i laktati kao i njihove kombinacije u smislu predviđanja ishoda kod odraslih kritično obolelih pacijenata sa sekundarnom sepsom. Metode: Prospektivnim istraživanjem je obuhvaćeno ukupno 86 krit...

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confidence: 90%

Composite bioscore is superior to routine biomarkers and established scoring systems in predicting mortality in adult critically ill patients with secondary sepsis

et al. 2021

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“…Since neutrophils are the first responders to both tissue damage and invading pathogens [8,9], multiple studies focused on neutrophils as potential biomarkers [10][11][12][13][14][15][16]. Biomarkers that were suggested after trauma included neutrophil C5aR expression [13,14], neutrophil extracellular traps (NETs) [17], neutrophil CD64 expression [18,19], neutrophil cell size [20], and neutrophil formyl-methionyl-leucyl-phenylalanine (fMLF)-induced FcγRII expression, of which only the latter was found to be an early marker in multiple trauma cohorts [21,22]. Neutrophil fMLF-induced FcγRII expression measured immediately after trauma showed high sensitivity (90%) for the prediction of severe sepsis ≥ 5 days post-trauma [21].…”

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confidence: 99%

New automated analysis to monitor neutrophil function point-of-care in the intensive care unit after trauma

Hesselink

Spijkerman

Fraiture

et al. 2020

ICMx

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Background: Patients often develop infectious complications after severe trauma. No biomarkers exist that enable early identification of patients who are at risk. Neutrophils are important immune cells that combat these infections by phagocytosis and killing of pathogens. Analysis of neutrophil function used to be laborious and was therefore not applicable in routine diagnostics. Hence, we developed a quick and pointof-care method to assess a critical part of neutrophil function, neutrophil phagosomal acidification. The aim of this study was to investigate whether this method was able to analyze neutrophil functionality in severely injured patients and whether a relation with the development of infectious complications was present. Results: Fifteen severely injured patients (median ISS of 33) were included, of whom 6 developed an infection between day 4 and day 9 after trauma. The injury severity score did not significantly differ between patients who developed an infection and patients who did not (p = 0.529). Patients who developed an infection showed increased acidification immediately after trauma (p = 0.006) and after 3 days (p = 0.026) and a decrease in the days thereafter to levels in the lower normal range. In contrast, patients who did not develop infectious complications showed high-normal acidification within the first days and increased tasset to identify patients at risk for infections after trauma and to monitor the inflammatory state of these trauma patients. Conclusion: Neutrophil function can be measured in the ICU setting by rapid point-of-care analysis of phagosomal acidification. This analysis differed between trauma patients who developed infectious complications and trauma patients who did not. Therefore, this assay might prove a valuable asset to identify patients at risk for infections after trauma and to monitor the inflammatory state of these trauma patients.

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“…Dramatic expansion of the GR-1 + CD11b + cells in late sepsis was also documented in this study 17 . Predictive value of many components of immune response in sepsis, regarding disease severity and outcome, has been investigated; future large sample studies are required to explore MDSCs in this regard 29,30 .…”

Section: Discussionmentioning

confidence: 99%

Myeloid-derived suppressor cells in secondary sepsis: Is there an association with lethal outcome?

Udovičić

Šurbatović

Rondović

et al. 2020

VSP

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Background/Aim. Role of myeloid-derived suppressor cells (MDSCs) in human host response to sepsis still needs to be clarified. The aim of our study was to determine whether frequency and/or absolute numbers of the MDSCs were associated with outcome in critically ill patients with secondary sepsis and/or septic shock. Methods. Total of 40 critically ill patients with secondary sepsis were enrolled in a prospective study. We detected and enumerated both main subsets of MDSCs: granulocytic (G)-MDSCs and monocytic (M)-MDSCs on the Day 1 (the day of hospital admission) and the Day 5 after the. The primary end-point was hospital mortality. Results. Increased frequencies and absolute numbers of subpopulations corresponding to MDSCs were associated with poor outcome. As far as relative kinetics was concerned, in both survivors and non-survivors, sepsis duration from 1th to 5th day was accompanied by an increase in MDSCs values of both investigated subpopulations. In contrast to findings of stepwise multivariate logistic regression analysis of the variables on the Day 1, on the Day 5 it was determined that the Sequential Organ Failure Assessment (SOFA) score (OR 2.350; p < 0.05) and G-MDSCs frequencies (OR 3.575; p < 0.05) were independent predictors of lethal outcome. Conclusion. These findings suggest harmful role of MDSCs in secondary sepsis.

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Prognostic Value And Daily Trend Of Interleukin-6, Neutrophil CD64 Expression, C-Reactive Protein And Lipopolysaccharide-Binding Protein In Critically Ill Patients: Reliable Predictors Of Outcome Or Not?

Cited by 28 publications

References 47 publications

Composite bioscore is superior to routine biomarkers and established scoring systems in predicting mortality in adult critically ill patients with secondary sepsis

Composite bioscore is superior to routine biomarkers and established scoring systems in predicting mortality in adult critically ill patients with secondary sepsis

New automated analysis to monitor neutrophil function point-of-care in the intensive care unit after trauma

Myeloid-derived suppressor cells in secondary sepsis: Is there an association with lethal outcome?

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